The Center for Dissemination and Implementation Science in Health Disparities (CDIS) was established in 2017 to understand, evaluate, and address the processes that promote or inhibit the adoption of evidence-based and empirically supported interventions for underserved populations in real-life settings in the US and globally. The Center’s scholarship focuses on the determinants of intervention implementation specifically focused on prevention and treatment of health disparity populations, including facilitators, barriers, and constraints; strategies to improve implementation; and key implementation outcomes, namely adoption/uptake, feasibility, acceptability, cost-effectiveness, sustainability, and fidelity of interventions and programs targeting underserved populations. The CDIS faculty, staff, and students apply these concepts to a broad range of chronic health problems with demonstrated disparities in underrepresented populations (e.g., mental health, smoking cessation, asthma, adolescent sexual and reproductive health, HIV prevention and treatment, substance use and addiction, aging and cognitive health, homelessness, Latinx immigrant health, juvenile justice). CDIS faculty and staff actively engage diverse communities in their research and evaluate innovative methodologies uniquely tailored for marginalized populations. In addition to the Center’s research and scholarship, the CDIS offers broad-based and comprehensive implementation science educational opportunities and capacity building for the University of Illinois System and its local, national, and international partners.