Ashley Kendall, PhD and colleagues at UIC examined the mood boost from nicotine among young adults when used alone and with the addition of cannabis and/or alcohol using ecological moments assessment (EMA) reports. From before to after smoking, positive affect increased and negative affect decreased, on average. Overall, the additions of cannabis and/or alcohol had non-significant associations with these mean changes. However, polysubstance use, as well as cigarette-cannabis co-use, were each associated with significantly greater within-person variability in the positive and negative affect changes related to smoking. The mood benefits associated with smoking were more erratic in the contexts of polysubstance use and cigarette-cannabis co-use.

Kendall AD, Hedeker D, Diviak KR, Mermelstein RJ. The Mood Boost from Tobacco Cigarettes is More Erratic with the Additions of Cannabis and Alcohol. Nicotine Tob Res. 2022 Jan 6:ntac001. doi: 10.1093/ntr/ntac001. Epub ahead of print. PMID: 34999839.