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UID:2026042111070320250428T13000020250428T14000069e80317e1fc1@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20250313T083419
DTSTART:20250428T130000
DTEND:20250428T140000
SUMMARY:Alexa Gajda, PhD Candidate (University of Illinois at Chicago): Thesis Defense
DESCRIPTION:Host: Emrah Er, PhD    Cellular stiffness profoundly impacts cancer metastasis at multiple levels, but mechanisms that regulate cancer cells? stiffness remain poorly understood. Here, we identified potassium efflux and KCNMB1, an auxiliary subunit of the large conductance potassium efflux (BK) channels, as regulators of cellular stiffness downstream of myocardin related transcription factor A (MRTFA). Genetic manipulation of KCNMB1 expression yielded changes in actin cytoskeleton organization and intracellular potassium levels, highlighting the ionic regulation of stiffness in cancer cells and pointing to BK channel agonism as a plausible therapeutic approach in cancer. | Event post: https://chicago.medicine.uic.edu/physiology/events?page_id=1982
LOCATION:Moss Auditorium - 1020 COMRB    Select 
CLASS:PRIVATE
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