Liangyou Rui, PhD (University of Michigan): “m6A-based Epitranscriptomicsin Health and Metabolic Disease”
February 20, 2026
11:00 AM - 12:00 PM
Location
Moss Auditorium, 1020 COMRB
Calendar
Download iCal FileHost: Yuwei Jiang, PhD
RNA modifications emerge as a critical mechanism to govern cell proliferation, differentiation, and function. METTL14 is an essential component of the N⁶-methyladenosine (m⁶A) transferase that deposits m⁶A methylation on RNA. YTHDC1 specifically binds m⁶A -methylated RNA to regulate RNA fate. We generated and characterized genetically modified mice with deletion of Mettl14 or Ythdc1 in adipocytes, hepatocytes, or neurons. Our results demonstrate that the METTL14/ m⁶A /YTHDC1 epitranscriptomic pathway shapes the activities of these cells and is indispensable for the maintenance of energy balance and metabolic homeostasis.
Date posted
Sep 12, 2025
Date updated
Feb 6, 2026
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