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Jan 31 2025

Andrew Ewald, PhD (Johns Hopkins): “How do cancer cells metastasize and how can we stop them?”

January 31, 2025

11:00 AM - 12:00 PM

Location

Moss Auditorium - 1020 COMRB

Host: Emrah Er, PhD

Cancer mortality is driven by metastasis. We showed that luminal breast cancer cells initiate invasion by expressing basal epithelial genes, such as keratin 14. K14+ luminal breast cancer cells invade and intravasate as adherent clusters. Conversely, triple negative breast cancer (TNBC) cells invade and metastasize in a hybrid EMT state, with clusters also favored. In both contexts, we observe transitions in cell state as cancer cells form growing metastases in distant organs. We are using scRNA-seq and epigenetic analysis to define the molecular states driving metastasis. Our goal is to identify proteins that can be targeted to eliminate metastases.

 

Contact

Heather Engholm

Date posted

Jan 8, 2025

Date updated

Jan 14, 2025

Speakers

Andrew Ewald | PhD | Johns Hopkins