Xiaoping Du, MD, PhD
Professor
Department of Pharmacology & Regenerative Medicine
Contact
Building & Room:
4131 COMRB
Address:
909 S Wolcott
Office Phone:
Email:
Related Sites:
Lab
Building & Room:
4120 COMRB
Office Phone:
About
Research Interests
Research interests of my laboratory are in the field of thrombosis, hemostasis, and vascular biology. Specifically, we study cell adhesion and signaling, including: 1) signaling mechanisms of platelet adhesion receptor, glycoprotein Ib-IX. 2) signaling mechanisms of integrins, particularly β3 integrins. 3) role of GTP binding proteins in platelet activation, and 4) role of nitric oxide-cGMP-dependent signaling pathway in regulating platelet function.
Selected Awards and Honors
- 2010 University Scholar, The University of Illinois
- 2013 Distinguished Investigator Award, The University of Illinois
- 2013 AHA 2013 ATVB Special Recognition Award in Thrombosis
Selected Publications
Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SC, Du X. A directional switch of integrin signalling and a new anti-thrombotic strategy. Nature. 503:131-135, 2013.
Yin H, Stojanovic-Terpo A, Xu W, Corken A, Zakharov A, Qian F, Pavlovic S, Krbanjevic A, Lyubimov AV, Wang ZJ, Ware J, Du X. Role for Platelet Glycoprotein Ib-IX and Effects of its Inhibition in Endotoxemia-Induced Thrombosis, Thrombocytopenia, and Mortality. Arterioscler Thromb Vasc Biol. 33:2529-2537, 2013.
Estevez B, Stojanovic-Terpo A, Delaney MK, O’Brien KA, Berndt MC, Ruan C, Du X. LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood. 121:4586-94, 2013.
Gong H, Shen B, Flevaris P, Chow C, Lam S C-T, Voyno-Yasenetskaya T, Kozasa T, Du X. G protein subunit Ga13 binds to integrin aIIbb3 and mediates integrin “outside-in” signaling. Science. 327:340-343, 2010.
Yin H, Stojanovic A, Hay N, Du X. The role of Akt in the VWF/GPIb-IX-induced platelet activation. Blood. 111:658-665, 2008.
Xi X, Bodnar RJ, Li Z, Lam S C-T, Du X. Critical roles for the NITY and RGT sequences of the integrin b3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol. 162:329-339, 2003.
Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for the cGMP-dependent protein kinase in platelet activation. Cell. 112: 77-86, 2003