Vigneshwaran Vellingiri

Vigneshwaran Vellingiri, Mehta D. TERTing the hyperoxic lung. Am J Physiol Heart Circ Physiol. 2021. doi: 10.1152/ajpheart.00580.2021. PMID: 34738834.

Akhter MZ, Yazbeck P, Tauseef M, Anwar M, Hossen F, Datta S, Vellingiri V, Chandra Joshi J, Toth PT, Srivastava N, Lenzini S, Zhou G, Lee J, Jain MK, Shin JW, Mehta D. FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity. Cell Rep. 2024 Jun 25;43(6):114297. doi: 10.1016/j.celrep.2024.114297.

Joshi JC, Joshi B, Zhang C, Banerjee S, Vellingiri V, Raghunathrao VAB, Anwar M, Rokade TP, Zhang L, Amin R, Song Y, Mehta D. RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury. iScience. 2025 Jan 27;28(2):111878. doi: 10.1016/j.isci.2025.111878.

Rayees S, Joshi JC, Joshi B, Vellingiri Vigneshwaran, Banerjee S, Mehta D. Protease-activated receptor 2 promotes clearance of Pseudomonas aeruginosa infection by inducing cAMP-Rac1 signaling in alveolar macrophages. Front Pharmacol. 2022 Sep 20;13:874197. doi: 10.3389/fphar.2022.874197. PMID: 36204227

Balaji Ragunathrao VA, Vellingiri V, Anwar M, Akhter MZ, Mehta D. S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?. Mol Cell Oncol. 2020;7(4):1746131. doi: 10.1080/23723556.2020.1746131. eCollection 2020. PubMed PMID: 32944615;

V. Vigneshwaran, P Thirusangu, B.R. Vijay Avin, V. Krishna, S.N. Pramod, B.T. Prabhakar. Immunomodulatory Glc/Man‐directed Dolichos lablab Lectin (DLL) evokes antitumor response in‐vivo by counteracting angiogenic gene expressions, Clinical & Experimental Immunology (2017).

V. Vigneshwaran, P Thirusangu, S. Madusudana, V. Krishna, S.N. Pramod, B.T. Prabhakar. The latex sap of the ‘Old World Plant’ Lagenaria siceraria with potent lectin activity mitigates neoplastic malignancy targeting neovasculature and cell death, International Immunopharmacology 39 (2016) 158–171.

P Thirusangu, V. Vigneshwaran, T. Prashanth, B.R. Vijay Avin et al., BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation. Angiogenesis (2017) 20 (1), 55–71.

MS - University of Mysore
PHD - Kuvempu University

NAVBO (North American Vascular Biology Organization) -Active (2022-Present)

American Physiological Society (APS) – Active (2022-Present)

ASPET – Active (2023-2024)

American Heart Association (AHA) – (Past)

Vigneshwaran Vellingiri, BR Vijay Avin, Jagdish Chandra Joshi, and Dolly Mehta, Endothelial ERG determines the Immune Niche and Vascular Homeostasis, Abstract published in FASEB Journal  (2021) – https://doi.org/10.1096/fasebj.2021.35.S1.04283 (Experimental Biology, 2021)

Vigneshwaran Vellingiri, Vijay Avin Balaji Ragunathrao, Jagdish Chandra Joshi, Md Zahid Akhter, Mumtaz Anwar, Somenath Banerjee, Steven Dudek, Yoshikazu Tsukasaki, Sandra Pinho, Dolly Mehta, Programming of neutrophil transcriptome by endothelial ERG maintains anti-inflammatory vascular niche in the lungs, American Physiology Summit (APS) 2024, Long beach California

Nithish R Prasad, Vigneshwaran Vellingiri, Asrar B Malik, Dolly Mehta, Yoshikazu Tsukasaki, Highly Motile Pulmonary Neutrophil Cytoplast is required to ameliorate Bacterial Pneumonia, University of Illinois Chicago, 2023, Immunology2024, The American Association of Immunologists (AAI Immunology 2024 conference) May 2024.

Dr Vigneshwaran Vellingiri is currently investigating the underlying mechanisms that regulate endothelial functions. Particularly his research focusses on the EC specific genes in maintaining anti-inflammatory niche to prevent neutrophil activation and inflammatory injury. This will help in developing effective treatments of vascular diseases such as cardiovascular disorders, Chronic kidney disease and lung injury through new means of preventing the activation of endothelium