Clinical and Pharmaceutical Studies Active Projects
Active Projects
Research by Hsu, Lewis
Sponsor
London North West Healthcare NHS Trust (UK)
Title
Marie Sklodowska-Curie Actions – Research and Innovation Staff Exchange
Description
The role of Dr. Hsu and UIC Sickle Cell Center role will be specifically to “train the trainers” on sickle cell disease Community Health Workers and Implementation Science, including.
(1) In short courses and workshops, Dr. Lewis Hsu will train ARISE personnel in the principles of Community Health Workers (CHW) and Implementation Science, and practical application to sickle cell disease. The “train the trainer” approach will equip the ARISE personnel to identify local stakeholders in sickle cell, align the goals of these multiple stakeholder groups when introducing new programs, assess their readiness for change, and empower the stakeholders in continuous evaluation of program quality.
(2) ARISE exchange personnel may apply for courses at UIC, which has College of Medicine, College of Nursing, College of Pharmacy, College of Applied Health Sciences, School of Public Health, College of Business Administration, College of Education, College of Dentistry, College of Engineering, College of Urban Planning and Public Affairs, College of Social Work, College of Liberal Arts and Sciences.
(3) Regular check-in with the African and European faculty on program outcomes and sustainability. They will encourage publication of these Implementation Science experiences, which will facilitate further development of sickle cell programs in sub-Saharan Africa.
Research by PI Hsu, Lewis
Funding
The University of Alabama at Birmingham (Prime sponsor: NIH)
Title
DISPLACE
Abstract
DISPLACE is a national, 28-site study, looking at what keeps some children from getting transcranial Doppler exams. Strokes are a common concern for people with sickle cell disease. Sickle cells are misshaped red blood cells that don’t flow easily in the body. They can clump up in brain arteries, damaging the walls of blood vessels and leading to strokes. A transcranial Doppler, or TCD, measures how quickly blood is flowing through vessels in the brain. If we do a TCD and it’s abnormal, you can start transfusion therapy and prevent stroke. Why doesn’t every child with sickle disease get transcranial Doppler screening as often as needed? That’s what the study will find out.
Research by Hsu, Lewis
Sponsor
Lurie (Ann & Robert H) Children’s Hospital of Chicago (Prime Sponsor: NIH)
Title
The Pro-Inflammatory Effects of Acute Exercise in Children with Sickle Cell Anemia
Description
UIC is participating in a multi-site study hosted at Lurie Children’s Hospital of Chicago examining the pro-inflammatory effects of moderate to vigorous physical activity and exercise in children with sickle cell anemia (SCA). The ultimate goal of the study to develop evidence-based guidelines for exercise and physical activity as a transformative strategy to maintain physical functioning and health in children with SCA.
Research by Hsu, Lewis
Sponsor
NIH
Title
Sickle Cell Disease Implementation Consortium (SCDIC)
Description
UIC is one of 8 sites in the Sickle Cell Disease Implementation Consortium (SCDIC), the first research program to use Implementation Science to identify and address barriers to quality care in Sickle Cell Disease (SCD). A SCD Registry enrolled 300 adolescents and young adults per site.
SCDIC then launched 2 implementation research studies:
- Care Redesign (MESH) aims to improve adherence to hydroxyurea therapy with two innovative interventions utilizing mobile health (mHealth)
- Emergency Department (ALIGN) Protocol aims to improve management of vaso-occlusive episodes by embedding Individualized Pain Plans in the electronic health record.
Dr. Hsu is among 5 multi-PI’s.
Research by Hsu, Lewis
Sponsor
HRSA
Title
STORM
Description
STORM builds a functional, sustainable, synergistic network to improve the outcomes and care for patients with sickle cell disease (SCD) in the Midwest.
Goals include:
- Increase the number of providers treating individuals with sickle cell disease (SCD) using evidence-based guidelines.
- Expand our STORM TeleECHO telementoring project to increase the number of providers administering evidence-based sickle cell care.
- Develop and implement strategies, such as quality improvement and provider education to improve access to quality care with an emphasis on individual and family engagement/partnerships, adolescent transition to adult life, and care in a medical home.
Dr. Hsu is Site PI.
Research by Hsu, Lewis and Sindura Jamalapur (Fellow)
Title
Heart Rate Variability in Pediatric Patients with and without Sickle Cell Disease as a measure of autonomic dysfunction
Research by Hsu, Lewis and Mary Yarney (Medical Student)
Title
Infographics and videos for sickle cell family health education in Ghana
Research by Hsu, Lewis, Alia Welsh (Medical Student) and Cristiana Hentea (Hem-Onc Faculty)
Title
COVID-19 vaccination of children with PHO conditions and working with families regarding vaccine hesitancy
Research by Hsu, Lewis and Olalekan Olorunyomi (Medical Student)
Title
Motivators and Barriers of Physical Activity Among Adolescents with Sickle Cell Disease
Research by Hsu, Lewis and Tierra Hunter (Medical Student)
Title
The Improvement of Health Literacy and Communication focused on the Understanding of the Long-Term Risks of Gene Therapy for Sickle Cell Anemia
Research by Hsu, Lewis and College of Education
Title
NSF INCLUDES Alliance Sickle Multidisciplinary STEM In Collaboration (Sickle MUSIC)
Research by Murphy, Shannon
Title
Project INITIATE
Research by Pillers, De-Ann
Funder
IL Dept of Public Health (IDPH)
Title
University of Illinois Administrative Perinatal Center
Research by Pillers, De-Ann
Funder
Gerber Foundation
Title
Optimizing Intravenous Protein Nutrition in Premature Infants Using Urine Metabolomics
Research by Pillers, De-Ann
Funder
Duke Clinical Research Institute (Prime Sponsor: NIH)
Title
Safety of Furosemide in Premature Infants at Risk of Bronchopulmonary Dysplasia
Research by Pillers, De-Ann
Title
A randomized double blind…IBP-9414…
Research by Pillers, De-Ann
Title
A phase 2b, multicenter…SHP607…
Research by Pillers, De-Ann
Title
Safety of sildenafil …
Research by Pillers, De-Ann
Title
Consortium for Neonatal Intensive Care Unit
Research by Schmidt, Mary
Funder
Children’s Oncology Group/Children’s Hospital of Philadelphia (Prime sponsor: NIH), St Baldrick’s Foundation, Circle of Service Foundation
Title
Many cancer studies
Research by Solomon, Marla
Funder
Medtronic Inc
Title
Diabetes Care in Schools: An Educational Program for School Nurses and Deligated Care Aides
Research by Srinivasan, Nishant
Title
Wearable sensors and video recording for children (birth to 24 months) to monitor motor development
Research by Tsai, Anne
Title
Enhancement of Newborn Screening Diagnostic Paradigms to Improve the Efficacy of Treatment for Krabbe Disease, Pompe Disease, and Mucopolysaccharidosisis Type 1