Molecular Pathology

The Molecular Pathology Laboratory preforms diagnostic testing in the areas of infectious disease, oncology and genetics utilizing commercial and in-house developed assays. A key strength of the laboratory is the development and validation of cutting edge tests in-house, with the goal of translating basic molecular knowledge to the actual practice of clinical medicine. The laboratory is well equipped with the latest instrumentation and performs over 25,000 test a year with the continual addition of new tests. In addition, the lab actively participates in translational research with the aim of developing molecular tests for clinical applications. The Molecular Pathology test menu is listed below.

Infectious Disease

HIV, HBV, HCV, CMV and BKV viral loads
HCV genotyping
BioFire Respiratory panel
Bacterial Fingerprinting by rep-PCR

Oncology

BCL-ABL, p210 and 190, PML-RARa,  CBFb -MYH11 (Inv16), RUNX1-ETO  – Qualitative
BCR-ABL, p210, JAK2 V617F mutation – Quantitative
BCR-ABL mutation (entire kinase domain by sequencing)
Chimerism analysis by real time PCR (analytical sensitivity of 0.05%)
Microsatellite instability (MSI, mononucleotide panel)
KRAS mutation
BRAF mutation
EGFR mutation (exons 18 – 21)

Genetics

Factor V, Factor II, MTHFR Mutation C677T  & A1298 C
Warfarin genetics (CYP2C9, VKORC1, CYP4F2)
Clopidogrel resistance – CYP2C19 genotype
Warfarin genetics and clopidogrel resistance testing supports the personalized medicine initiative of the Pharmacogenetic program at UIC

Director

Shrihari S. Kadkol, MD, PhD, HCLD
Phone: 312-355-3521

Manager

Carol Dodge
Phone: 312-996-2917
Email: [email protected]

Supervisors

Lynn Terrile, [email protected]
Mei Shen, [email protected]
Phone: 312-996-7702

Contact Information

Hours of Operation:  8:00 am to 5:00 pm, Monday through Friday
Phone:                           312-996-7702
312-996-2660
Address:                       Pathology Laboratories
2nd Floor, Clinical Sciences Building
840 South Wood Street (MC 750)
Chicago, IL 60612