Recent Publications

2015 – Present

Alexander Agelidis

Jaisankar D, Yakoub AM, Yadavalli T, Agelidis A, Thakkar N, Hadigal S, Ames J, Shukla D. An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye. Science Translational Medicine 10 (428), eaan5681 (2018).

Yadavalli T, Agelidis A, Jaishankar D, Mangano K, Thakkar N, Penmetcha K, Shukla D. Targeting herpes simplex virus-1 gD by a DNA aptamer can be an effective new strategy to curb viral infection. Molecular Therapy-Nucleic Acids 9, 365-378 (2017).

Agelidis AM, Hadigal SR, Jaishankar D, Shukla D. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. Cell Reports 20(2), 439-50 (2017).

Thakkar N, Jaishankar D, Agelidis A, Yadavalli T< Mangano K, Patel S, Tekin SZ, Shukla D. Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells. Scientific Reports 7, (2017).

Hadigal SR*, Agelidis AM*, Karasneh GA, Antoine TE, Yakoub AM, Ramani VC, Djalilian AR, Sanderson RD, Shukla D. Heparanase is a host enzyme required for herpes simplex virus-1 release from cells. Nature Communications 6, 6985 (2015).

Agelidis AM, Shukla D. Cell entry mechanisms of herpes simplex virus: what we have learned in recent years. Future Virology 10, 1145-1154 (2015).

Sarah Baumgarten

Baumgarten SC, Convissar SM, Zamah AM, Fierro MA, Winston NJ, Scoccia B, and Stocco C (2015) FSH regulates IGF-2 expression in human granulosa cells in an AKT dependent manner. JCEM, 100(8):1046-1055.

Tiffani Berkel

Berkel, Tiffani DM, and Subhash C. Pandey. “Emerging role of epigenetic mechanisms in alcohol addiction.” Alcoholism: Clinical and Experimental Research 41.4 (2017): 666-680.

Krishnan H, Sakharkar A, Teppen T, Berkel T, Pandey S. The Epigenetic Landscape of Alcoholism. In Subhash C. Pandey, editor: Epigenetics, Vol 115, IRN, UK: Academic Press, 2014, pp. 75-116.

(Submitted. Review Pending) Geraghty JR, Young AN, Berkel TDM, Wallbruch E, Mann J, Hirshfield LE, Park YS, Hyderi A (2018) Empowering Medical Students as Agents of Curricular Change: The University of Illinois at Chicago Student Curricular Board. Academic Medicine.

Berkel, Tiffani DM, et al. “Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol.” International Journal of Neuropsychopharmacology 22.4 (2018): 292-302.

Russell Dulman

Augier E, Barbier E, Dulman RS, Licheri V, Augier G, Domi E, Barchiesi R, Farris S, Natt D, Mayfield RD, Adermark, L, Heilig M (2018). A Molecular Mechanism for Choosing Alcohol over an Alternative Reward. Science 360(6395): 1321-1326.

Osama El-Sayed

Dexter Hadley, James Pan, Osama El-Sayed, Jihad Al-Jabban, Imad Al-Jabban, Tej Azad, Mohamed Hadied, Shuaib Raza, Benjamin Abhishek Rayikanti, Bin Chen, Hyojung Paik, Dvir Aran, Jordan Spatz, Daniel Himmelstein, Maryam Panahiazar, Sanchita Bhattacharya, Marina Sirota, Mark Musen, Atul J. Butte.Precision annotation of digital samples in NCBI’s Gene Expression Omnibus. Scientific Data. 2017.

Alharshawi K, Marinelerena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein A, Maker A, Prabhakar B. PKC-Θ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells. Scientific Reports. 2017

Michael Fettiplace

Fettiplace MR, Kowal K, Ripper R, Young A, Lis K, Rubinstein I, Bonini M, Minshall R, Weinberg G. Sensitization of insulinergic signaling upstream of mTOR is required for spontaneous recovery from bupivacaine-induced cardiac toxicity and potentiated by lipid emulsion. Anesthesiology 2016; 124(2):428-42.

Joseph Geraghty

Geraghty JR, Davis JL, Testai FD. Neuroinflammation and microvascular dysfunction after subarachnoid hemorrhage: A review. Stroke. 2018. Manuscript in preparation.

Geraghty JR*, Young AN*, Berkel TDM, Wallbruch E, Mann J, Hirshfield LE, Park YS, Hyderi A. Empowering medical students as agents of curricular change: The University of Illinois at Chicago Student Curricular Board. Teaching and Learning in Medicine. 2018. Manuscript in preparation. *co-first author

Geraghty JR and Testai FD. Delayed cerebral ischemia after subarachnoid hemorrhage: Beyond vasospasm and towards a multifactorial pathophysiology. Curr Atheroscler Rep. 2017;19:50.

Hobbs JG, Desai B, Young JS, Polster SP, Tobin MK, Geraghty JR, Linninger AA, Oyelese AA, Shin JH, Bydon M, and Mehta AI. Intramedullary spinal cord tumors: A review and discussion of surgical rationale. World Spinal Column Journal 2:65-83, 2016

Tobin MK*, Geraghty JR*, Engelhard HH, Linninger AA, and Mehta AI. Intramedullary spinal cord tumors: A review of current and future treatment strategies. Neurosurg Focus 39(2):E14, 2015. *Co-first author

Artemis Gogos

Gogos A, Federle MJ. 2019. Accepted. Modeling Pharyngeal Colonization by Streptococcus pyogenes in the Mouse. Frontiers in Microbiology.

Gogos A, Jiminez J, Chang JC, Wilkening RV, Federle MJ. 2018. A quorum sensing-regulated protein binds cell-wall components and enhances lysozyme resistance in Streptococcus pyogenes. Journal of Bacteriology.

Pérez Morales TG, Ratia K, Wang D-SS, Gogos A, Driver TG, Federle MJ. 2017. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. Journal of Biological Chemistry.

Gogos A, Jiminez J, Chang JC, Wilkening RV, Federle MJ. 2018 A quorum sensing-regulated protein binds cell-wall components and enhances lysozyme resistance in Streptococcus pyogenes. Journal of Bacteriology.

Pérez Morales TG, Ratia K, Wang D-SS, Gogos A, Driver TG, Federle MJ. 2017. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. J. Biol. Chem.

Joseph Goldenberg

Goldenberg JR, Wang X, Lewandowski ED. Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice. J. Mol. Cell. Cardiol. 2016

Kataria Y, Deaton RJ, Enk E, Jin M, Petrauskaite M, Dong L, Goldenberg JR, Colter SJ, Jensen DM, van Breeman RB, Gann PH. Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer. BMC Gastroenterol. 2016;16:30.

Ben Gordon

Kastrati, I., Semina, S., Gordon, B., Smart, E. (2019). Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer. Molecular and Cellular Endocrinology.

Laura Hardy

Hardy, L.R., Salvi, A., Burdette, J.B. UnPAXing the Divergent Roles of PAX2 and PAX8 in High-Grade Serous Ovarian Cancer. Cancers 2018 August 8:10(8). PMID: 30096791.

Russo, A., Czarnecki, A.A., Dean, M., Modi, D.A., Lantvit, D.D., Hardy, L.R., Baligod, S., Davis, D.A., Wei, J., Burdette, J.E. PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation. Oncogene 2018 January 25:1. PMID: 29367766.

Rodgers, L.H.*, O’hAinmhire, E.*, Young, A.H., Burdette, J.E. Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium. Oncotarget 7.22 (2016): 32785

Mir Isaamullah

P. Balaram, M. Isaamullah, H. M. Petry, M. E. Bickford, J. H. Kaas, Distributions of vesicular glutamate transporters 1 and 2 in the visual system of tree shrews (Tupaia belangeri). The Journal of comparative neurology 523, 1792-1808 (2015

Jane Ivakhnitskaia

Ivakhnitskaia, E., Hamada, K., & Chang, C. (2016). Timing mechanisms in neuronal pathfinding, synaptic reorganization, and neuronal regeneration. Develop. Growth Differ. 58(1): 88-93. doi: 10.1111/dgd.12259. PMID: 26748770.

Ivakhnitskaia, E., Lin, R.W., Hamada, K., Chang, C. (2018). Timing of neuronal plasticity in development and aging. Wiley Interdiscip. Rev. Dev. Biol. 7(2). Doi:10.1002/wdev.305. PMID: 29139210.

Hirata, H., Dallacasagrande, V., Mizerska, K., Ivakhnitskaia, E., Rosenblatt, M.I. (2018). Ambient Air Currents Activate Corneal Nerves During Ocular Dessication in Rats: Simultaneous Recordings of Neural Activity and Corneal Temperature. Invest. Ophthalmol. Vis. Sci. 59(10): 4031-4043. Doi:10.1167/iovs18-24604. PMID: 30098191.

Evan Kyzar

Zhang H, Kyzar E, Bohnsack J, Kokare D, Teppen T, Pandey S. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Sci Rep; 2018: 8(1):10376.

Kyzar E, Nichols C, Gainetdinov R, Nichols D, Kalueff A. Psychedelic drugs in biomedicine. Trends Pharmacol Sci; 2017: 38(11):992-1005.

Kokare D, Kyzar E, Zhang H, Sakharkar A, Pandey S. Adolescent alcohol exposure-induced changes in alpha-melanocyte stimulating hormone and neuropeptide Y pathways via histone acetylation in the brain during adulthood. Int J Neuropsychopharmacol; 2017: 20(9):758-768.

Pandey S, Kyzar E, Zhang H. Epigenetic basis of the dark side of alcohol addiction. Neuropharmacology; 2017: 122:74-84.

Kyzar E, Zhang H, Sakharkar A, Pandey S. Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood. Addict Biol; 2017: 22(5):1191-1204

Meshalkina D, Kizlyuk M, Kisel E, Collier A, Echevarria D, Abreu M, Barcellos L, Song C, Warnick J, Kyzar E, Kalueff A. Zebrafish models of autism spectrum disorder. Exp Neurol; 2017: 299(Pt A):207-216.

Kyzar E, Banerjee R. Targeted epigenetic modulation of gene expression in the brain. J Neurosci; 2016: 36:9283-9285

Kyzar E, Floreani C, Teppen T, Pandey S. Adolescent alcohol exposure: Burden of epigenetic reprogramming, synaptic remodeling, and adult psychopathology. Front Neurosci; 2016: 10:222.

Song C, Yang L, Wang J, Chen P, Li S, Liu Y, Nguyen M, Kaluyeva A, Kyzar E, Gaikwad S, Kalueff A. Building neurophenomics in zebrafish: effects of prior testing stress and test batteries. Behav Brain Res, 2016: 311:24-30.

Homberg J*, Kyzar E*, Scattoni M, Norton W, Pittman J, Gaikwad S, Nguyen M, Poudel M, Ullmann J, Diamond D, Kaluyeva A, Parker M, Brown R, Song C, Gainetdinov R, Gottesman I, Kalueff A. Genetic and environmental modulation of neurodevelopmental disorders: translational insights from labs to beds. Brain Res Bull, 2016: 125:79-91.

Homberg J*, Kyzar E*, Nguyen M, Norton W, Pittman J, Poudel M, Gaikwad S, Nakamura S, Koshiba M, Yamanouchi H, Scattoni M, Ullman J, Diamond D, Kaluyeva A, Parker M, Klimenko V, Apryatin S, Brown R, Song C, Gainetdinov R, Gottesman I, Kalueff A. Understanding autism and other neurodevelopmental disorders through experimental translational neurobehavioral models. Neurosci Biobehav Rev, 2016: 65:292-312.

Kyzar E, Kalueff A. Exploring hallucinogen pharmacology and psychedelic medicine with zebrafish models. Zebrafish, 2016: 13(5):379-90.

Homberg J*, Kyzar E*, Stewart A, Nguyen M, Poudel M, Echevarria D, Collier A, Gaikwad S, Klimenko V, Norton W, Pittman J, Nakamura S, Koshiba M, Yamanouchi H, Apryatin S, Scattoni M, Diamond D, Ullmann J, Parker M, Brown R, Song C, Kalueff A. Improving treatment of neurodevelopmental disorders: Recommendations based on preclinical studies. Expert Opin Drug Discov; 2016; 11(1):11-25.

Kyzar E, Stewart A, Kalueff A. Effects of LSD on grooming behavior in serotonin transporter heterozygous (Sert+/-) mice. Behav Brain Res; 2016; 296:47-52.

Kalueff A, Echevarria D, Homechaudhuri S, Stewart A, Collier A, Kaluyeva A, Li S, Liu Y, Chen P, Wang J, Yang L, Mitra A, Pal S, Chaudhuri A, Roy A, Biswas M, Roy D, Podder A, Poudel M, Katare D, Mani R, Kyzar E, Gaikwad S, Nguyen M, Song C, ZNRC. Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research. Aquat Toxicol; 2016; 170:297-309.

Stewart A, Grieco F, Tegelenbosch R, Kyzar E, Nguyen M, Kaluyeva A, Song C, Noldus L, Kalueff A. A novel 3D method of locomotor analysis in adult zebrafish: implications for automated detection of CNS drug-evoked phenotypes. J Neurosci Methods; 2015; 255:66-74.

Kyzar E, Pandey S. Molecular mechanisms of synaptic remodeling in alcoholism. Neurosci Lett; 2015; 601:11-9.

Matthew MacDougall

Xiaoguang Sun, Venkateswaran Ramamoorthi Elangovan, Brandon Mapes, Sara M Camp, Saad Sammani, Laleh Saadat, Ermelinda Ceco, Shwu-Fan Ma, Carlos Flores, Matthew S MacDougall, Hector Quijada, Bin Liu, Carrie L Kempf, Ting Wang, Eddie T Chiang, and Joe G.N. Garcia. NAMPT Promoter Regulation by Mechanical Stress, STAT5 and ARDS-Associated Genetic Variants. Am J Respir Cell Mol Biol. May 2014. Epub ahead of print.

Brian R. Shy, Matthew S. MacDougall, Ryan Clarke, Bradley J. Merrill. Co-Incident Insertion (COIN) Mediated High Efficiency Genome Engineering in Embryonic Stem Cells. Accepted with revisions at Nucleic Acids Research. 2016

Ryan Clarke, Robert Heler, Matthew S MacDougall, Nan Cher Yeo, Alejandro Chavez, Maureen Regan, Leslyn Hanakahi, George M. Church, Luciano A. Marraffini, Bradley J. Merrill. Enhanced bacterial immunity and mammalian genome editing via RNApolymerase-mediated dislodging of Cas9 from double strand DNA breaks. Molecular Cell, 2018.

MacDougall, Matthew S., Daniel J. Gittings, and Jaimo Ahn. “Post-traumatic Ankle Arthropathy Treated with Arthrodesis.” Fractures of the Foot and Ankle. Springer, Cham, 2018. 225-232.

Christopher Manzella

Manzella, C., Singhal, M., Alrefai, W. A., Saksena, S., Dudeja, P. K., & Gill, R. K. (2018). Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR. Scientific Reports, 8(1), 6103. http://doi.org/10.1038/s41598-018-24213-5

Zhang, Y.-G., Singhal, M., Lin, Z., Manzella, C., Kumar, A., Alrefai, W. A., et al. (2018). Infection with enteric pathogens Salmonella typhimurium and Citrobacter rodentium modulate TGF-beta/Smad Signaling Pathways in the Intestine. Gut Microbes, 146, 0–00. http://doi.org/10.1080/19490976.2018.1429878

Singhal M, Manzella C, Soni V, Alrefai WA, Saksena S, Hecht G, Dudeja PK, Gill RK. Role of SHP2 Protein Tyrosine Phosphatase in SERT Inhibition by Enteropathogenic E. coli (EPEC). The American Journal of Physiology – Gastrointestinal and Liver Physiology. Feb 2017.

Alejandra Marinelarena

Marinelarena, Alejandra, et al. “Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T cells.” Scientific reports 8.1 (2018): 14940.

Kumar, P., Marinelarena, A., Raghunathan, D., Ragothaman, V.K., Saini, S., Bhattacharya, P., Fan, J., Epstein, A.L., Maker, A.V., and Prabhakar, B.S. Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation. Cell Mol Immunol. 2018.

Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein AL, Maker AV, Prabhakar BS. PKC-theta is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells. Sci Rep. 2017;7(1):6594.

Kumar P, Alharshawi K, Bhattacharya P, Marinelarena A, Haddad C, Sun Z, Chiba S, Epstein AL, Prabhakar BS. Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling. Sci Rep. 2017;7:39751.

Michael Marshall

Marshall, M. S., Issa, Y., Jakubauskas, B., Stoskute, M., Elackattu, V., Marshall, J. N., . . . Bongarzone, E. R. (2018). Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe’s Disease after Global Gene Therapy. Mol Ther, 26(3), 874-889. doi:10.1016/j.ymthe.2018.01.009

Marshall, M. S., Jakubauskas, B., Bogue, W., Stoskute, M., Hauck, Z., Rue, E., . . . Bongarzone, E. R. (2018). Analysis of age-related changes in psychosine metabolism in the human brain. PLoS One, 13(2), e0193438. doi:10.1371/journal.pone.0193438

Marshall, M. S., & Bongarzone, E. R. (2016). Beyond Krabbe’s disease: The potential contribution of galactosylceramidase deficiency to neuronal vulnerability in late-onset synucleinopathies. Journal of Neuroscience Research, 94(11), 1328-1332. doi:10.1002/jnr.23751

Abdelkarim, H*, Marshall, M.S.*, Scesa, G., Smith, R., Rue, E., Marshall, J., Elackattu, V., Stoskute, M., Issa, Y., Santos, M., Nguyen, D., Hauck, Z., van Breemen, R., Celej, S., Gaponenko, V., and Ernesto R. Bongarzone. Alpha-synuclein interacts directly but reversibly with psychosine: implications for alpha-synucleinopathies. Scientific Reports, Accepted August 1, 2018.

*These authors contributed equally to this work

Smith, B. R.*, Santos, M. B.*, Marshall, M. S.*, Cantuti-Castelvetri, L., Lopez-Rosas, A., Li, G., . . . Bongarzone, E. R. (2014). Neuronal inclusions of alpha-synuclein contribute to the pathogenesis of Krabbe disease. J Pathol, 232(5), 509-521. doi:10.1002/path.4328

* These authors contributed equally to this work

Karumuthil-Melethil, S., Marshall, M. S., Heindel, C., Jakubauskas, B., Bongarzone, E. R., & Gray, S. J. (2016). Intrathecal administration of AAV/GALC vectors in 10-11-day-old twitcher mice improves survival and is enhanced by bone marrow transplant. Journal of Neuroscience Research, 94(11), 1138-1151. doi:10.1002/jnr.23882

Moyano, A. L., Steplowski, J., Wang, H., Son, K. N., Rapolti, D. I., Marshall, J., Elackattu, V., Marshall, M.S., . . . Bongarzone, E. R. (2018). microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler’s Virus-Induced Demyelinating Disease. Mol Ther, 26(3), 730-743. doi:10.1016/j.ymthe.2018.01.008

Cantuti-Castelvetri, L., Maravilla, E., Marshall, M., Tamayo, T., D’Auria, L., Monge, J., . . . Bongarzone, E. R. (2015). Mechanism of neuromuscular dysfunction in Krabbe disease. Journal of Neuroscience, 35(4), 1606-1616. doi:10.1523/JNEUROSCI.2431-14.2015

Bradbury, A. M., Rafi, M. A., Bagel, J. H., Brisson, B. K., Marshall, M. S., Pesayco Salvador, J., . . . Vite, C. H. (2018). AAVrh10 Gene Therapy Ameliorates Central and Peripheral Nervous System Disease in Canine Globoid Cell Leukodystrophy (Krabbe Disease). Hum Gene Ther, 29(7), 785-801. doi:10.1089/hum.2017.151

D’Auria, L., Reiter, C., Ward, E., Moyano, A. L., Marshall, M. S., Nguyen, D., . . . Bongarzone, E. R. (2017). Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease. PLoS One, 12(5), e0178103. doi:10.1371/journal.pone.0178103

Richard Marszalek

Chavan TS, Muratcioglu S, Marszalek R, Jang H, Keskin O, Gursoy A, Nussinov R, Gaponenko V. Plasma membrane regulates Ras signaling networks. Cell Logist. 2016 Feb 18;5(4):e1136374.

Amanda Mennie

Mennie AK, Hoyle A, Moser BA, Los RS, Tanaka K, Nakamura TM. Anti-TEL patch motif in Tpz1 prevents telomerase activation and protects telomere against fusions by modulating Stn1-Ten complex in fission yeast. Communications Biology. 2018.

Mennie AK, Moser BA, Nakamura TM. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nature Communications. 2018 Feb 8;9(1):586. http://dx.doi.org/10.1038/s41467-018-02874-0

Ma MC, Pettus JM, Jakoubek JA, Traxler MG, Clark KC, Mennie AK, Kwitek AE. Contribution of Independent and Pleiotropic Genetic Effects in the Metabolic Syndrome in a Hypertensive Rat. PLos One. 2017 Aug 8;12(8):e0182650. http://dx.doi.org/10.1371/journal.pone.0182650

Wang J, Ma MC, Mennie AK, Pettus JM, Lin L, Traxler MG, Jakoubek J, Atanur SS, Aitman TJ, Xing Y, Kwitek AE. Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat. Circ Cardiovasc Genet. 2015 Apr; 8 (2): 316-326. http://dx.doi.org/10.1161/CIRCGENETICS.114.000520

Uzoagu Okonkwo

Okonkwo, U.A.; DiPietro, L.A. Diabetes and Wound Angiogenesis. Int. J. Mol. Sci. 2017, 18, 1419.

Urao, N., Okonkwo, U. A., Fang, M. M., Zhuang, Z. W., Koh, T. J., & Dipietro, L. A. (2016). MicroCT angiography detects vascular formation and regression in skin wound healing. Microvascular Research, 106, 57-66. doi:10.1016/j.mvr.2016.03.006

Alan Perez Rathke

Perez-Rathke, A., Fahie, M.A., Chisholm, C., Liang, J. and Chen, M., 2018. Mechanism of OmpG pH-dependent gating from loop ensemble and single channel studies. Journal of the American Chemical Society, 140(3), pp.1105-1115.

Perez-Rathke A., Chisholm, C., Chen, M., Liang, J. 2018. Pretzel: a Computational Framework for Loop-Driven, Membrane Protein Gating. In preparation.

Wang, B., Perez-Rathke, A., Li, R. and Liang, J., 2018, March. A general method for predicting amino acid residues experiencing hydrogen exchange. In … IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics (Vol. 2018, p. 341). NIH Public Access.

Perez-Rathke, A., Li, H. and Lussier, Y.A., 2013. Interpreting personal transcriptomes: personalized mechanism-scale profiling of RNA-seq data. In Biocomputing 2013 (pp. 159-170).

Mladen Rasic

Zulueta J, Piscitello A, Rasic M, et al. Predicting Mood Disturbance Severity with Mobile Phone Keystroke Metadata: A BiAffect Digital Phenotyping Study. Eysenbach G, ed. Journal of Medical Internet Research. 2018;20(7):e241. doi:10.2196/jmir.9775.

Cory Reiter

Moyano AL, Steplowski J, Wang H, Song KN, Rapolti DI, Marshall J, Elackattu V, Marshall MS, Hebert AK, Reiter CR, Ulloa V, Pituch KC, Givogri MI, Lu QR, Lipton HL, Bongarzone ER. microRNA-219 reduces viral load and pathologic changes in Theiler’s virus-induced demyelinating disease. Molecular Therapy. doi:10.1016/j.ymthe.2018.01.008.

D’Auria L, Reiter C, Ward E, Moyano AL, Marshall MS, Nguyen D, Scesa G, Hauck Z, van Breemen R, Givogri MI, Bongarzone ER. (2017) Psychosine enhances the shedding of membrane microvesicles: Implications in demyelination in Krabbe’s disease. PLoS ONE 12(5): e0178103.

Tanner Roach

Mills, K. A., Roach, S. T., Quinn, J. M., Guo, L., Beck, H. M., Lomonosova, E., … & McCourt, C. (2018). SQ1274, a novel microtubule inhibitor, inhibits ovarian and uterine cancer cell growth. Gynecologic oncology, 151(2), 337-344.

Laura Rodgers

Chang, Y.C., Khanal, A.K, Bradley, J., Rodgers, L., Ngamskulrungroj, P., Kwon-Chung, K. (2015). Differences between Cryptococcus neoformans and Cryptococcus gattii in the Molecular Mechanisms Governing Utilization of D-Amino Acids as the Sole Nitrogen Source. PLoS ONE.

Adam Schafer

Cheng H, Schafer A, Soloveva V, et al. Identification of a coumarin-based antihistamine-like small molecule as an anti-filoviral entry inhibitor. Antiviral Research. 2017;145:24-32. doi:10.1016/j.antiviral.2017.06.015

Schafer, A., Cheng, H., Xiong, R., Soloveva, V., Retterer, C., Mo, F., . . . Rong, L. (2018). Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Research, 157, 47-56. doi:S0166-3542(18)30301-2 [pii]

Cui, Q., Du, R., Anantpadma, M., Schafer, A., Hou, L., Tian, J., . . . Rong, L. (2018). Identification of ellagic acid from plant rhodiola rosea L. as an anti-ebola virus entry inhibitor. Viruses, 10(4), 10.3390/v10040152. doi:E152 [pii]

Han, J., Perez, J., Schafer, A., Cheng, H., Peet, N., Rong, L., & Manicassamy, B. (2017). Influenza virus: Small molecule therapeutics and mechanisms of antiviral resistance. Current Medicinal Chemistry, doi:10.2174/0929867324666170920165926 [doi]

Schafer, A. M., Cheng, H., Lee, C., Du, R., Han, J., Perez, J., . . . Rong, L. (2017). Development of potential small molecule therapeutics for treatment of ebola virus. Current Medicinal Chemistry, doi:10.2174/0929867324666171010141416 [doi]

Cody Schott

Ascoli C, Huang Y, Schott C, Turturice BA, Metwally A, Perkins DL, Finn PW, Group AR. A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis. Am J Respir Cell Mol Biol. 2017. Epub 2017/08/17. doi: 10.1165/rcmb.2017-0207OC. PubMed PMID: 28812922.

Schott C, Weigt SS, Turturice BA, Metwally A, Belperio J, Finn PW, Perkins DL. Bronchiolitis obliterans syndrome susceptibility and the pulmonary microbiome. J Heart Lung Transplant. 2018. Epub 2018/06/23. doi: 10.1016/j.healun.2018.04.007. PubMed PMID: 29929823.

Erin Shanker

Shanker E, Federle MJ. Quorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans. Genes (Basel). 2017;8(1). doi: 10.3390/genes8010015. PubMed PMID: 28067778.

Shanker E, Morrison DA, Talagas A, Nessler S, Federle MJ, Prehna G. Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species. PLoS Pathog. 2016;12(12):e1005979. doi: 10.1371/journal.ppat.1005979. PubMed PMID: 27907154.

Rachael Smith

Abdelkarim, H., Marshall, M.S., Scesa, G., Smith, R.A., Rue, E., Marshall, J., Elackattu, V., Stoskute, M., Issa, Y., Santos, M., Nguyen, D., Hauck, Z., Breemen, R., Celej, S., Gaponenko, V., Bongarzone, E.R. α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies. Scientific Reports. 8. 2018. DOI: 10.1038/s41598-018-30808-9

Peters, A.T., Smith R.A., Kassel, M.T., Maki, P., Van Meter, A., Briceño, E.M., Ryan, K.A., Hagan, M., Weldon, A.L., Weisenbach, S.L., Starkman, M.N., Langenecker, S.A. A pilot investigation of differential neuroendocrine associations with fronto-limbic activation during semantically-cued list learning in mood disorders. Journal of Affective Disorders. 239. 2018. DOI: 10.1016/j.jad.2018.07.006.

Cornelius, J., Perreau, G., Bishop, V., Krause, J., Smith, R., Hahn, T., Meddle, S. Social information changes stress hormone receptor expression in the songbird brain. Hormones and Behavior. 97. 2018. DOI: 10.1016/j.yhbeh.2017.10.002.

Rubin, L.H., Wu, M., Sundermann, E.E., Meyer, V.J., Smith, R., Weber, K.M., Cohen, M.H., Little, D.M., & Maki, P.M. Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV. Journal of NeuroVirology. 22(6). 2016. DOI: 10.1007/s13365-016-0446-3

Terilyn Stephen

Pietruczyk, EA; Stephen, TKL; Alford, S; Lutz, SE. Laminectomy and Spinal Cord Window Implantation in the Mouse. JoVE. In press

Justin Sysol

H Tang, J Chen, DR Fraidenburg, S Song, JR Sysol, AR Drennan, S Offermanns, RD Ye, MG Bonini, RD Minshall, JGN Garcia, RF Machado, A Makino, JXJ Yuan. “Deficiency of Akt1, but not Akt2, Attenuates the Development of Pulmonary Hypertension.” Am J Physiol Lung Cell Mol Physiol. 308(2):L208-20 (2015).

JR Sysol, RF Machado. “Sickle Cell Disease and Acute Chest Syndrome: Epidemiology, Diagnosis, Management, Outcomes.” Hematologic Abnormalities and Acute Lung Syndromes. Springer Series in Respiratory Medicine. In Press, 2016.

Alexander Terry

Sang-Min Jeon, Prashanth Bhaskar, Dannielle DeWaal, Alexander R. Terry, Brooks Robey, and Nissim Hay. Retrograde signaling by mitochondrial hexokinases. Science Signaling. (In review)

Carolina Pusec, Adam De Jesus, Md. Wasim Khan, Alexander Terry, Anton Ludvik, Kai Xu, Nicholas Giancola, Haaris Pervaiz, Emily Smith, Xianzhong Ding, Stephen Harrison, Issam Ben-Sahra, Navdeep Chandel, Nissim Hay, Hossein Ardehali, Jose Cordoba-Chacon, and Brian Layden. HKDC1 is a non-canonical hexokinase that associates with NAFLD and contributes to liver metabolic reprogramming. Endocrinology (In review)

Dannielle DeWaal, Veronique Nogueira, Alexander R. Terry, Krushna C. Patra, Sang-Min Jeon, Grace Guzman, Jennifer Au, Christopher long, Maciek R. Antoniewicz, Nissim Hay. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nature Communications 9(446).

Alexander Ticho

Ticho AL, Malhotra P, Dudeja PK, Gill RK, Alrefai WA. Bile acid receptors and gastrointestinal functions. Liver Research. In Revision.

Ticho AL, Lee H, Gill RK, Dudeja PK, Saksena S, Lee D, Alrefai WA. A novel bioluminescence-based method to investigate uptake of bile acids in living cells. American Journal of Physiology – Gastrointestinal and Liver Physiology. June 2018.

Sharma M, Ticho AL, Samankumara L, Zeller M, Brückner C. Conformational landscapes of metal(II) porphyrinato, chlorinato, and morpholinochlorinato complexes. Inorganic Chemistry. June 2017.

Ticho AL, Alrefai WA. Chronic ethanol exposure closes the door to vitamin C in pancreatic acinar cells. Focus on “Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure”. Am. J. Physiol., Cell Physiol. American Physiological Society. 2016 July 1;311(1):C127–8.

Matthew Tobin

Tobin MK, Lopez K, Pergande MR, Bartholomew AM, Cologna SM, Lazarov O. Mesenchymal stem cells induce recovery after stroke by regulation of inflammation and oligodendrogenesis. Nat Med, 2018, manuscript in preparation.

Tobin MK, Musaraca K, Bheri A, Kim N, Bennett DA, Lazarov O. Persistance of adult hippocampal neurogenesis through aging and cognitive dysfunction. Cell Stem Cell, 2018, submitted.

Tobin MK, Scheer JK, Geraghty JR, Lau D, Ames CP, Neckrysh S. Cervical kyphotic deformity managed with upper thoracic pedicle subtraction osteotomy: Clinical parameters and outcome analysis of 13 cases. J Neurosurg Spine, 2018, manuscript in preparation.

Tang T, Dong L, Ridgley DM, Ghura S, Tobin MK, Sun GY, LaDu MJ, Lee, JC. Cytosolic phospholipase A2 facilitates oligomeric amyloid-β peptide association with microglia. Mol Neurobiol, 2018, accepted.

Hollands C, Tobin MK, Hsu M, Musaraca K, Yu T-S, Mishra R, Kernie SG, Lazarov O. Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition. Mol Neurodegener. 2017, 12(1):64. PMID: 28886753.

Tobin MK, Birk D, Siemionow K, Neckrysh S, Schizas C. T1 pedicle subtraction osteotomy for the treatment of rigid cervical kyphotic deformity: clinical series of four patients and review of the literature. J Neurosurg Spine. 2017, 27(5):487-493. PMID: 28841105

Rangwala SD, Tobin MK, Birk DM, Butts JT, Nikas DC, Hahn YS. Pica in a child with anterior cingulate gyrus oligodendroglioma: Case report. Pediatr Neurosurg. 2017, 52(4):279-283. PMID: 28704833.

Rangwala SD, Birk DM, Tobin MK, Hahn YS, Nikas DC. Spontaneous resolution of spinal epidural hematoma resulting from domestic child abuse: Case report. Pediatr Neurosurg. 2017, 52(1):51-54. PMID: 27644085.

Bonds JA, Kuttner-Hirshler Y, Bartolotti N, Tobin MK, Pizzi M, Marr R, Lazarov O. Presenilin-1 dependent neurogenesis regulates hippocampal learning and memory. PLoS One. 2015, 10(6):e0131266. PMID: 26098332.

Birk DM, Tobin MK, Moss HE, Feinstein E, Charbel FT, Alaraj A. Improvement in venous outflow following superior sagittal sinus decompression after a gunshot wound to the head: Case report. J Neurosurg. 2015, 123(1):81-85. PMID: 25839927.

Alaraj A, Tobin M, Birk D, Aletich V. Role of argatroban during neurointerventional procedures in patients with heparin-induced thrombocytopenia. J Neurointerv Surg. 2014, 6(8):630-632. PMID: 24062254.

Tobin MK, Arnone GD, Kheirkhah P, Denyer S, Mehta AI. Intramedullary spinal cord tumors: Research areas and future therapies, in: Tumors of the Spinal Canal: Surgical Approaches and Future Therapies. 2018, manuscript in preparation.

Tobin MK, Testai FD: Rare genetic causes of stroke, in Caplan LR, Biller J, Leary MC, Lo EH, Thomas AJ, Yenari M, Zhang JH (eds): Primer on Cerebrovascular Diseases, Second Edition. Academic Press, 2017, pp. 545-554.

Birk DM, Tobin MK, Slavin KV: Neurosurgical options for control of chronic and malignant abdominal pain, in Kapural L (ed): Chronic Abdominal pain: An Evidence Based, Comprehensive Guide to Clinical Management. Springer, 2014, pp. 239-244.

Alaraj A, Tobin MK, Birk DM, Charbel FT: Simulation for neurosurgery and neurosurgical procedures, in Levine AI, DeMaria S, Schwartz AD, Sim AJ (eds): The Comprehensive Textbook of Healthcare Simulation. Springer, 2013, pp. 415-423.

Skeoch GD, Tobin MK, Khan S, Linninger AA, Mehta AI. Corticosteroid treatment for metastatic spinal cord compression: A review. Global Spine J. 2017, 7(3):272-279. PMID: 28660111.

Genev IK*, Tobin MK*, Zaidi S, Khan S, Amirouche F, Metha AI. Spinal compression fracture management: A review of current treatment strategies and possible future avenues. Global Spine J. 2017, 7(1):71-82. PMID: 28451512. *These authors contributed equally to the work.

Hobbs JG, Desai B, Young JS, Polster SP, Tobin MK, Geraghty JR, Linninger AA, Oyelese AA, Shin JH, Bydon M, Mehta AI. Intramedullary spinal cord tumors: A review and discussion of surgical rationale. World Spinal Column J. 2016, 7(2):65-83.

Tobin MK*, Geraghty JR*, Engelhard HH, Linninger AA, Mehta AI. Intramedullary spinal cord tumors: A review of current and future treatment strategies. Neurosurg Focus. 2015, 39(2):E14. PMID: 26235012. *These authors contributed equally to the work.

Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD, Lazarov O. Neurogenesis and inflammation following ischemic stroke: what is known and where we go from here. J Cereb Blood Flow Metab. 2014, 34(10):1573-1584. PMID: 25074747.

Antony AK, Rodby K, Tobin MK, O’Connor MI, Pearl RK, DiPietro LA, Breidenbach WC, Bartholomew AM. Composite tissue allotransplantation and dysregulation in tissue repair and regeneration: a role for mesenchymal stem cells. Front Immunol. 2013, 4:188. PMID: 23847625.

Alaraj, A, Charbel FT, Birk D, Tobin M, Luciano C, Banerjee PP, Rizzi S, Sorenson J, Foley K, Slavin K, Roitberg B. Role of cranial and spinal virtual and augmented reality simulation using Immersive Touch modules in neurosurgical training. Neurosurgery. 2013, 72(Suppl 1):A115-A123. PMID: 23254799.

Alan Tseng

Kim K, Li J, Tseng A, Andrews RK, Cho J. NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation. Blood. 2015, PMID: 26333777

Tseng A, Kim K, Li J, Cho J. Myeloperoxidase Negatively Regulates Neutrophil–Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation. Frontiers in Medicine. 2018;5:134. doi:10.3389/fmed.2018.00134.

Kim K, Li J, Barazia A, et al. ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease. Haematologica. 2017;102(2):246-259. doi:10.3324/haematol.2016.151159.

Kim K, Tseng A, Barazia A, Italiano JE, Cho J. DREAM plays an important role in platelet activation and thrombogenesis. Blood. 2017;129(2):209-225. doi:10.1182/blood-2016-07-724419.

Benjamin Turturice

Turturice BA, Ranjan R, Nguyen B, Hughes LM, Andropolis KE, Gold DR, Litonjua AA, Oken E, Perkins DL, Finn PW (2017) Perinatal Bacterial Exposure Contributes to IL-13 Aeroallergen Response. American journal of respiratory cell and molecular biology 57 (4), 419-427

Ozturk AB, Turturice BA, Perkins DL, Finn PW (2017) The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma. Current allergy and asthma reports 17 (9), 62

Turturice BA, Mcgee HS, Oliver B, Baraket M, Nguyen BT, Ascoli C, Ranjan R, Rani A, Perkins DL, Finn PW (2017) Atopic Asthmatic Immune Phenotypes Associated with Airway Microbiota and Airway Obstruction. PloS one 12 (10), e0184566

Christian Ascoli, Yue Huang, Cody Schott, Benjamin A Turturice, Ahmed Metwally, David L Perkins, Patricia W Finn, ACCESS Research Group. (2017) A Circulating Micro-RNA Signature Serves as a Diagnostic and Prognostic Indicator in Sarcoidosis. Am J Respir Cell Mol Biol. 10.1165/rcmb.2017-0207OC

Cody Schott, S Samuel Weigt, Benjamin A Turturice, Ahmed Metwally, John Belperio, Patricia W Finn, David L Perkins (2018) Bronchiolitis obliterans syndrome susceptibility and the pulmonary microbiome. The Journal of Heart and Lung Transplantation 2018/4/26

Ozge Nur Aktas, Benjamin Turturice, David L Perkins, Patricia W Finn (2018) Microbiome: Allergic Diseases of Childhood. Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. 35-53

Reid Wilkening

Wilkening, R.V., Chang, J.C., Federle, M.J. PepO, a CovRS-controlled endopeptidase, disrupts Streptococcus pyogenes quorum sensing. Mol. Microbiol, 2016. 99(1): 71-87.

Wilkening RV, Federle MJ. Evolutionary Constraints Shaping Streptococcus pyogenes–Host Interactions. Trends Microbiol, 2017. 25(7) 562-572.

Wilkening, R.V.*, Capodagli, G.C.*, Khataokar, A.*, Tylor, K.M., Neiditch, M.B., Federle, M.J. “Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond.” J. Biol. Chem. 2017, 292 20544-20557 [*co-authors]

Gogos, A., Jimenez, J.C., Chang, J.C., Wilkening, R.V., Federle, M.J. “A quorum sensing-regulated protein binds cell-wall components and enhances lysozyme resistance in Streptococcus pyogenes. J. Bacteriol. 2018, doi: 10.1128/JB.00701-17.

Pavlova, S.I., Wilkening, R.V., Federle, M.J., Lu, Y., Schwartz, J., Tao, L. “Streptococcus endopeptidase promote HPV infection in vitro.” MicrobiologyOpen, 2018. Accepted manuscript.

Allen Ye

Y Liang, AQ Ye, W Chen, R Gatto, L Colon-Perez, T Mareci, R Magin. A new fractal derivative model for the characterization of anomalous diffusion in magnetic resonance imaging. Manuscript accepted at Communications in Nonlinear Science and Numerical Simulation

B Schwartz, Z Yin, K Yasar, Y Liu, A Khan, AQ Ye, T Royston, R Magin. Scattering and Diffraction in a Concentric Cylindrical Phantom for MR Elastograpy. IEEE Transactions on Biomedical Engineering (2016). DOI:10.1109/TBME.2016.2527825

AQ Ye, G Thomas-Ramos, J Keiriz, O Ajilore, A Kumar, R Magin, J Leigh, A Leow. Understanding and Visualizing the Intrinsic Geometry of Brain Connectomes Using Dimensionality Reduction Techniques in 3D Immersive Virtual Environment. Brain Informatics (2015), doi:10.1007/s40708-015-0022-2

S Ravindran, M Kotecha, CC Huang, AQ Ye, P Pothirajan, Z Yin, R Magin, A George. Characterization of Biomimetic Extracellular Matrix Scaffolds for Use in Cartilage Tissue Regeneration. Biomaterials 71 (2015): 58-70.

R Gatto, Y Chu, AQ Ye, S Price, E Tavassoli, A Buenaventura, A Lysakowsky, S Brady, R Magin, J Kordower, and G.Morfini. Analysis of YFP(J16)-R6/2 reporter mice and post-mortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington’s disease. Human Molecular Genetics (2015): ddv248.

AQ Ye, L Zhan, S Conrin, J GadElKarim, A Zhang, S Yang, J Feusner, A Kumar, O Ajilore, A Leow. Measuring embeddedness: Hierarchical scale-dependent information exchange efficiency of the human brain connectome. Human Brain Mapping 36, no. 9 (2015): 3653-3665.

Alexandria Young

Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, ALdrich LN, Fuchs JR, Burdette JE. Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high grade serous ovarian cancer by late-stage autophagy inhibition. Mol Cancer Ther 2018. In press.

Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR. Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignin lactones. Bioorg Med Chem 2018;26(9):2354-2364.

Young AN, Moyle-Heyrman G, Kim JJ, Burdette JE. Microphysiologic systems in female reproductive biology. Exper Biol Med 2017;242(17):1690-1700.

Rodgers, L.H.*, O’hAinmhire, E.*, Young, A.H., Burdette, J.E. Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium. Oncotarget. 2016 (in press)
Himes KP, Young A, Koppes E, Stolz D, Barak Y, Sadovsky Y, Chaillet JR. Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism. Placenta 2015;36(4):389-96.

Gangemi A, Young A, Elli EF. Case report: A rare sequela after a case of early bariatric surgery tourism. Surg Obes Relat Dis 2015;11(1):e1-3.

Cucinotta CE, Young AN, Klucevsek KM, Arndt KM. The nucleosome acidic patch regulates the H2B K123 monoubiquitylation cascade and transcription elongation in Saccharomyces cerevisiae. PLoS Genet 2015;11(8):e1005420.

Jenny Zhang

Zhang JY, Shy BR, Merrill BJ: Tcf7l1 (Tcf3) Mediated Enhancer Decommissioning Redirects Pluripotent Cell Response to Gsk3 inhibition. Cell Stem Cell. In revision, submitted 10/2017.

Ozmadenci D, Huyghe A, Furlan G, Galonska C, Combémorel N, Charlton J, Zhang JY, Hermitte S, Wajda P, Vieugué P, Durand I, Brevet M, Gadot N, Chazaud C, Merrill B, Mehlen P, Meissner A, and Fabrice Lavial: The netrin-1 signalling pathway is the non-chemical inducer of the ground state of pluripotency. Nature Cell Biology. In review, submitted 11/2017.

Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS: Complementary Wnt sources regulate lymphatic vascular development via PROX1-dependent Wnt/b-Catenin signaling. In Progress

Nguyen HA, Su Y, Zhang JY, Antanasijevic A, Caffrey M, Schalk AM, Liu L, Rondelli D, Oh A, Mahmud DL, Bosland MC, Kajdacsy-Balla A, Peirs S, Lammens T, Mondelaers V, De Moerloose B,, Goossens S,, Schlicht MJ, Kabirov KK, Lyubimov AV, Merrill BJ, Saunthararajah Y, Van Vlierberghe P, Lavie A: A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo. Cancer Res. 2018 Mar 15;78(6):1549-1560. doi: 10.1158/0008-5472.CAN-17-2106. Epub 2018 Jan 17.