My laboratory focuses on regeneration of penile smooth muscle and peripheral nerve regeneration in animal models of erectile dysfunction caused by prostate cancer treatment, diabetes and aging. We are developing a nanoparticle based delivery vehicle (peptide amphiphile) for proteins to the penis and cavernous nerve to promote regeneration. Potential rotations include: 1) Analysis of morphological changes in penis tissue from transgender patients. 2) Examining how effective delivery of proteins by peptide amphiphile are in an aging rat model. 3) Development of a rat model of male stress urinary incontinence. 4) Analysis of Sonic hedgehog pathway signaling in patient muscle tissue.