1. Virus-host interactions. This project is to study herpesvirus genes that manipulate innate immunity. The focus will be on the intracellular nucleic acid sensing machineries that control cytokine signaling and inflammation. The goal is to understand molecular mechanisms linked to lytic replication, latency, and pathogenesis.
2. Cancer immunotherapy. This project is to study genetically engineered viruses for cancer immunotherapy. It involves molecular analyses of therapeutic potency, immune activation, and oncolytic mechanisms in cell culture and pre-clinical models. The goal is to develop next generation oncolytic agents for cancer immunotherapy.