Bin He, PhD

Associate Professor
Work Room:8035 COMRB Work Phone: 312-996-4986
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Biographical Info

PhD, Purdue University

Research Interest

Viral infection and innate immunity

Viral infections trigger innate immunity that involves the recognition of pathogen-associated molecular patterns. In this process Toll-like receptors and cytosolic receptors engage with viruses, which activate a spectrum of transcription factors and regulate the production of interferon, inflammatory cytokines, and chemokines. Remarkably, these immune factors inhibit viral gene expression, protein synthesis, and replication. Additionally, the host immune factors prime the maturation of dendritic cells, stimulate natural killer cells, and activate T lymphocytes. A number of innate immune mechanisms operate in a cell-type specific and temporal manner. This partly stems from complex interactions of viruses and host cells. To replicate or persist in a host, viruses express an array of proteins that modulate cytokine induction, signal transduction, and effector functions. Accordingly, a dynamic interplay between a virus and host dictates the outcome of viral infection or pathogenesis. Our long-term goal is to understand the nature of immunity in virus infections, which may lead to the development of preventive or therapeutic measures. Our research areas are:
(1) Viral modulation of Toll-like receptor related pathways
(2) Regulation of cytokine expression in virus infections
(3) Mechanisms mediated by viral vaccine vectors



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Categories: Microbiology & Immunology Faculty