AMELIA BARTHOLOMEW, MD, MPH, FACS

PROFESSOR OF SURGERY

General Profile

Specialty:

Research

Appointments:

Chief, Translational Research
Director, Medical Student Surgical Education and Curriculum
Professor, Department of Surgery
Professor, Department of Bioengineering

Clinical Interests:

Stem Cell Biology
Organ regeneration
Nutrigenomics and Exercise

Languages Spoken:

English, Greek

Education

Medical Education:

Northwestern University, John Hopkins Bloomberg School of Public Health

Residency:

General Surgery, University of Illinois at Chicago

Fellowship:

Abdominal Organ Transplant, Massachusetts General Hospital

Certifications:

Diplomate of National Board of Medical Examiners, Illinois Medical License, Fellow of American College of Surgeons

Publications, Awards, & Memberships

Publications:

Mesenchymal Stem Cell Biology
Bartholomew, A., Patil, S., Mackay, A., Nelson,M., Buyaner,D., Hardy, W., Mosca, J., Sturgeon, C., Siatskas M., Mahmud, N., Ferrer, K., Deans, R., Hoffman, R., Devine. ” Baboon mesenchymal Stem Cells Can Be Genetically to Secrete Human Erythropoietin in Vivo” Hum Gene Ther. 2001;12(12):1527-41.Bartholomew, A., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K., Moran, S., Hardy, W., Devine, S., Deans, R., Moseley, A., Hoffman, R., ” Mesenchymal Stem Cells Suppress Lymphocyte Proliferation in Vitro and Prolong Skin Graft Survival In Vivo”, Exp Hematol. 2002; 30(1)1-7.Devine, S., Cobbs, C., Jennings, M., Bartholomew, A., Hoffman, R., “Mesenchymal stem cells distribute to a wide range of tissues followings systemic infusion into non-human primates”, Blood. 2003 Apr 15; 101(8):2999-3001. Epud 2002 Dec 12.

Moadsiri A, Polchert D, Genrich K, Napoles P, Reina E, Turian J, Smith B, Bartholomew A. “Mesenchymal Stem Cells Enhance Xenochimerism in NK Depleted Hosts,” Surgery. 2006 Aug;140(2):315-21.

Polchert, D, Sobinsky, J., Douglas, GW, Kidd, M, Moadsiri, A, Reina, E ., Genrich, K., Mehrota, S., Setty, S., Smith, B. and Bartholomew, A. IFN-gamma Activation of Mesenchymal Stem Cells For Treatment and Prevention of Graft versus Host Disease. European Journal of Immunology 2008 Jun (accompanied by editorial).

Bartholomew,A., Polchert, D.,Szilagyi,E.,Douglas,GW, Kenyon, N. “Mesenchymal Stem Cells in the Induction of Transplantation Tolerance,” Transplantation, 2009.

Berman DM, Willman MA, Han D, Kleiner G, Kenyon NM, Cabrera O, Karl JA, Wiseman RW, O’Connor DH, Bartholomew AM, Kenyon NS.Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates.2010 Oct;59(10):2558-68. Epub 2010 Jul 9.

Demars M, Bartholomew A, Strakova Z, Lazarov O.Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin.Stem Cell Res Ther. 2011 Aug 30;2(4):36.

Auletta JJ, Deans RJ, Bartholomew AM.Emerging roles for multipotent, bone marrow-derived stromal cells in host defense.Blood. 2012 Feb 23;119(8):1801-9.

Auletta JJ, Bartholomew AM, Maziarz RT, Deans RJ, Miller RH, Lazarus HM, Cohen JA.The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.Immunotherapy. 2012 May;4(5):529-47.

Lee S, Szilagyi E, Chen L, Premanand K, DiPietro LA, Ennis W, Bartholomew AM. Activated mesenchymal stem cells increase wound tensile strength in aged mouse model via macrophages.J Surg Res. 2013 May 1;181(1):20-4. Epub 2012 May 29.

Black EF, Marini L, Vaidya A, Berman D, Willman M, Salomon D, Bartholomew A, Kenyon N, McHenry K.Using Hidden Markov Models to Determine Changes in Subject Data over Time, Studying the Immunoregulatory effect of Mesenchymal Stem Cells.Proc IEEE Int Conf Escience. 2014 Oct;1:83-91.

Nutrigenomics and Exercise

Kaput J, Ordovas JM, Ferguson L, van Ommen B, Rodriguez RL, Allen L, Ames BN, Dawson K, German B, Krauss R, Malyj W, Archer MC, Barnes S, Bartholomew A, Birk R, van Bladeren P, Bradford KJ, Brown KH, Caetano R, Castle D, Chadwick R, Clarke S, Clement K, Cooney CA, Corella D, Manica da Cruz IB, Daniel H, Duster T, Ebbesson SO, Elliott R, Fairweather-Tait S, Felton J, Fenech M, Finley JW, Fogg-Johnson N, Gill-Garrison R, Gibney MJ, Gillies PJ, Gustafsson JA, Hartman Iv JL, He L, Hwang JK, Jais JP, Jang Y, Joost H, Junien C, Kanter M, Kibbe WA, Koletzko B, Korf BR, Kornman K, Krempin DW, Langin D, Lauren DR, Ho Lee J, Leveille GA, Lin SJ, Mathers J, Mayne M, McNabb W, Milner JA, Morgan P, Muller M, Nikolsky Y, van der Ouderaa F, Park T, Pensel N, Perez-Jimenez F, Poutanen K, Roberts M, Saris WH, Schuster G, Shelling AN, Simopoulos AP, Southon S, Tai ES, Towne B, Trayhurn P, Uauy R, Visek WJ, Warden C, Weiss R, Wiencke J, Winkler J, Wolff GL, Zhao-Wilson X, Zucker JD. The case for strategic international alliances to harness nutritional genomics for public and personal health.Br J Nutr. 2005 Nov;94(5):623-32.

Kaput J, Noble J, Hatipoglu B,Kohrs K, Dawson K, Bartholomew A. Application of nutrigenomic concepts to Type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2007 Feb;17(2):89-103.

LaStayo P, McDonagh P, Lipovic D, Napoles P, Bartholomew A, Esser K, Lindstedt S. Elderly patients and high force resistance exercise–a descriptive report: can an anabolic, muscle growth response occur without muscle damage or inflammation? J Geriatr Phys Ther. 2007;30(3):128-34.

Kaput J, Perlina A, Hatipoglu B, Bartholomew A, Nikolsky Y.Nutrigenomics: concepts and applications to pharmacogenomics and clinical medicine. Pharmacogenomics. 2007 Apr;8(4):369-90.

Tissue Regeneration

Antony AK, Rodby K, Tobin MK, O’Connor MI, Pearl RK, DiPietro LA, Breidenbach WC, Bartholomew AM.Composite tissue allotransplantation and dysregulation in tissue repair and regeneration: a role for mesenchymal stem cells.Front Immunol. 2013 Jul 9;4:188.

Ennis WJ, Sui A, Bartholomew A.Stem Cells and Healing: Impact on Inflammation.Adv Wound Care (New Rochelle). 2013 Sep;2(7):369-378.

Boyle M, Chun C, Strojny C, Narayanan R, Bartholomew A, Sundivakkam P, Alapati S.Chronic inflammation and angiogenic signaling axis impairs differentiation of dental-pulp stem cells.PLoS One. 2014 Nov 26;9(11):e113419. Epub 2013.

Strojny C, Boyle M, Bartholomew A, Sundivakkam P, Alapati S.Interferon Gamma-treated Dental Pulp Stem Cells Promote Human Mesenchymal Stem Cell Migration In Vitro.J Endod. 2015 Aug;41(8):1259-64. Epub 2015 Jun 4.

Yu JZ, Lindeblad M, Lyubimov A, Neri F, Smith B, Szilagyi E, Halliday L, MacVittie T, Nanda J, Bartholomew A.Subject-Based versus Population-Based Care after Radiation Exposure.Radiat Res. 2015 Jul;184(1):46-55. Epub 2015 Jun 29.

Additional publications can be found at
http://www.ncbi.nlm.nih.gov/sites/myncbi/amelia.bartholomew.1/bibliography/41140033/public/?sort=date&direction=ascending.