Victor H. Guaiquil PhDAssistant Research Professor of Ophthalmology, Corneal Regenerative Medicine Laboratory University of Illinois College of MedicineDepartment of Ophthalmology
Dr. Guaiquil’s current research is focused on the cellular and molecular mechanisms involved in angiogenesis and neurogenesis in the retina and cornea. Similar signaling mechanisms and growth factors are used in both processes in the eye that lead to profoundly distinct visual outcomes. For example, vascular endothelial growth factor (VEGF) activates the same receptors in endothelial and neuronal cells. In the newborn retina an excess of VEGF induces unwanted pathological neovascularization that left untreated might result in loss of vision or even blindness. While in the injured cornea VEGF promotes nerve regeneration, enhances the functional and trophic recovery, providing a better visual outcome. Dr. Guaiquil’s research elucidates these tissue specific effects which may lead to uncover new therapeutics to avoid vision loss. He is a Co-Investigator on the NEI supported R01 grant “Mechanisms of Corneal Nerve Repair.” Dr. Guaiquil joined the faculty in 2014
BS—University Austral of Chile
MS—University Austral of Chile
PhD in Molecular and Cellular Biology—State University of New York (SUNY) Downstate Medical Center, NY
Postdoctoral Fellow—Memorial Sloan-Kettering Cancer Center, New York, NY
Postdoctoral Fellow—Hospital for Special Surgery, New York, NY
Guaiquil VH, Pan Z, Karagianni N, Fukuoka S, Alegre G, Rosenblatt MI. Vascular Endothelial Growth Factor-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17272-7.
Maretzky T, Blobel CP, Guaiquil V. Characterization of Oxygen-Induced Retinopathy in Mice Carrying an Inactivating Point Mutation in the Catalytic Site of ADAM15. Invest Ophthalmol Vis Sci. 2014. 23;55(10):6774-82.
Guaiquil VH, Hewing N, Chiang MF, Rosenblatt MI, Chan RVP, Blobel CP. A murine model for retinopathy of prematurity identifies endothelial cell proliferation as a potential mechanism for plus disease. Invest Ophthalmol Vis Sci. 2013.54(8):5294-302.
Pan Z, Fukuoka S, Karagianni N, Guaiquil VH, Rosenblatt MI. Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FASEB J. 2013.(27):2756- 2767.