Sandeep Jain, MD
B.A. Field Professor of Ophthalmology
Director, Cornea Translational Biology Laboratory
Director, Dry Eye Service and oGVHD Service
Founder & Chief Executive Officer, Selagine Inc.
Illinois Eye and Ear Infirmary
1855 W. Taylor Street, M/C 648
Chicago, IL 60612
Sees patients at:
The Illinois Eye and Ear Infirmary
1855 W. Taylor Street
Dry Eye and oGVHD Clinic
Clinic Phone: (312) 996-8937
Work Email: [email protected]
Dry Eye Clinical Trial Phone Line: 312-918-0900
Schedule an Appointment
Dr. Sandeep Jain is Director of the Dry Eye and Ocular GVHD clinic at UI Health and BA Field Professor of Ophthalmology at the University of Illinois College of Medicine. Dr. Jain is Board certified in Ophthalmology. His clinical focus is in treatment of Dry Eye Diseases, with a particular interest in Ocular Graft-Vs.-Host Disease and Sjogren’s Syndrome. He is an NIH funded clinician scientist, who has discovered new mechanisms of inflammation in dry eyes and developed new drugs for treating dry eyes. Dr. Jain is the founding Program Director of the NEI/NIH funded Chronic GVHD Meeting in Chicago which focuses on the intersection between the areas of chronic GVHD and dry eye/ocular surface disease. He is also the founder of UIC’s “goGVHD Fund” which seeks to provide novel treatments to all patients with ocular GVHD who need them, irrespective of their ability to pay and to lead the next generation of innovation to cure this disease. He has received several awards including, UIC Inventor of the Year, UIC Faculty of the Year, American Academy of Ophthalmology’s Achievement Award, Research to Prevent Blindness Physician-Scientist Award, and has been listed among Castle Connolly Top Doctors in Chicago. After receiving his medical degree, Dr. Jain joined the Wilmer Ophthalmological Institute at The Johns Hopkins University as a pre-residency fellow and completed his residency training in Ophthalmology at the Harkness Eye Institute at Columbia University, New York, followed by subspecialty fellowship in Corneal Diseases at the Massachusetts Eye & Ear Infirmary/Harvard Medical School.
Dr. Jain’s clinical and translational research focus is on dry eye disease (DED) and ocular Graft-versus-host-disease (oGVHD). Dr. Jain has established a unique translational research program that makes feasible the discovery and development of novel treatments for ocular GVHD and dry eye disease. This program comprises of a highly specialized ocular GVHD and dry eye clinic for patient care, an advanced translational molecular biology laboratory for uncovering disease mechanisms, and a highly motivated team who seamlessly connect these components. Dr. Jain’s clinical practice and basic laboratory research are highly integrated around this focus area, which has allowed him to investigate the biological basis of clinical observations in DED and oGVHD. He discovered a novel mechanism for inflammation in dry eye disease and oGVHD that is based on the accumulation of neutrophil extracellular traps on the ocular surface. This research has led to numerous patent filings, an NEI/NIH R01 grant, NEI/NIH R24 grant, funding from UIC Chancellor’s Innovation Fund (CIF) Proof of Concept Awards program and a Physician Scientist award from Research to Prevent Blindness. This research has also led to multiple patent grants (US9867871B2 granted on Jan 16, 2018, US9877964B2 granted on Jan 30, 2018 and US9597328 B2 granted on Mar 21, 2017). Dr. Jain has published 75 papers in Journals and made more than 100 presentations in Ophthalmological meetings. He has also presented seminars for non-profit patient organizations such as BMT Infonet and AAMDS International Foundation.
Dr. Jain is experienced in the regulatory processes required for developing ophthalmic drugs. He was assigned two Investigator sponsored Investigational New Drug (IND) by FDA for developing DNase I and pooled human immune globulin (IVIG) eye drops. He is the Principal investigator on several ‘investigator-sponsored’ phase I/II clinical trials (clinicaltrials.gov NCT #NCT02193490, NCT02702518 and NCT00606905). His laboratory was the first to recognize the potential of several novel drugs to treat moderate to severe dry eye disease. These drugs include Brimonidine nanoemulsion (licensed to Ocugen Inc.), DNase eye drops (licensed to Neutrolis Inc.) and human immune globulin eye drops (licensed to Selagine Inc.). Brimonidine nanoemulsion became the first drug in the US to be receive orphan drug designation for treating ocular GVHD. Dr. Jain is the founder of two startup companies: Selagine Inc. and Advaite Inc.. Dr. Jain provides scientific consultation in the area of Dry Eye Disease to GlaxoSmithKline plc. and Roche.
UIC news releases:
1. UIC researcher awarded $10.15M to develop antibody-based dry eye treatment
2. Antibody-based eye drops show promise for treating dry eye disease
3. New treatment for severe dry eye disease promising in early clinical trials
4. Inventor of the Year: Sandeep Jain
5. UIC: An incubator for successful start-ups
Dr. Jain’s dry eye and oGVHD seminars for patients (YouTube videos):
1. Your Eyes and Chronic Graft versus Host Disease
2. Ocular GVHD – Diagnosis and Treatment
View Dr. Jain’s Patient Letters
MD—University of Delhi, India
Research Fellowship in Cornea and External Diseases—Wilmer Eye Institute, Johns Hopkins University, Baltimore
Residency—Harkness Eye Institute, Columbia University, New York
Clinical Fellowship in Cornea—Massachusetts Eye and Ear Infirmary, Harvard Medical School
Scholars for Teaching Excellence Faculty Fellowship, University of Illinois at Chicago
Selected Honors and Awards
University of Illinois at Chicago, Inventor of the Year Award
University of Illinois College of Medicine, Faculty of the Year Award
Research to Prevent Blindness, Physician Scientist Award
Castle Connolly Top Doctors in Chicago
Chicago Super Doctors
Best Doctors in America
American Academy of Ophthalmology Achievement Award
Sonawane S, Khanolkar V, Namavari A, Chaudhary S, Gandhi S, Tibrewal S, Jassim SH, Shaheen B, Hallak J, Horner JH, Newcomb M, Sarkar J, Jain S. Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease. Invest Ophthalmol Vis Sci. 2012;53:8253-63.
Accompanying editorial comment: McDermott AM. New insight into dry eye inflammation. Invest Ophthalmol Vis Sci. 2012 Dec 17;53(13):8264. doi:10.1167/iovs.12-11386.
Tibrewal S, Sarkar J, Jassim SH, Gandhi S, Sonawane S, Chaudhary S, Byun YS, Ivanir Y, Hallak J, Horner JH, Newcomb M, Jain S. Tear Fluid Extracellular DNA: Diagnostic and Therapeutic Implications in Dry Eye Disease. Invest Ophthalmol Vis Sci. 2013;54:8051-62.
Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I). Sci Rep. 2013;3:3419.
Tibrewal S, Ivanir Y, Sarkar J, Nayeb-Hashemi N, Bouchard CS, Kim E, Jain S. Hyperosmolar stress induces neutrophil extracellular trap formation: implications for dry eye disease. Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):7961-9.
Hallak JA, Tibrewal S, Mohindra N, Gao X, Jain S. Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study. Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5990-6.
Hallak JA, Tibrewal S, Jain S. Depressive Symptoms in Patients With Dry Eye Disease: A Case-Control Study Using the Beck Depression Inventory. Cornea. 2015 Dec;34(12):1545-50.
Sivaraman KR, Jivrajka RV, Soin K, Bouchard CS, Movahedan A, Shorter E, Jain S, Jacobs DS, Djalilian AR. Superior Limbic Keratoconjunctivitis-like Inflammation in Patients with Chronic Graft-Versus-Host Disease. Ocul Surf. 2016 May 11. pii: S1542-0124(16)30036-2.
Bron AJ, de Paiva CS, Chauhan SK, Bonini S, Gabison EE, Jain S, Knop E, Markoulli M, Ogawa Y, Perez V, Uchino Y, Yokoi N, Zoukhri D1, Sullivan DA. TFOS DEWS II pathophysiology report. Ocul Surf. 2017 Jul;15(3):438-510. PMID: 28736340.
Dry Eye Assessment and Management Study Research Group, Asbell PA, Maguire MG, Pistilli M, Ying GS, Szczotka-Flynn LB, Hardten DR, Lin MC, Shtein RM. n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease. N Engl J Med. 2018 May 3;378(18):1681-1690. PMID: 29652551.
Mun C, Gulati S, Tibrewal S, Chen YF, An S, Surenkhuu B, Raju I, Buwick M, Ahn A, Kwon JE, Atassi N, Pradeep A, Rondelli D, Jain S. A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease. Transl Vis Sci Technol. 2019 May 2;8(3):10. PMID: 31110911.
Sarkar J, Milani B, Kim E, An S, Kwon J, Jain S. Corneal nerve healing after in situ laser nerve transection. PLoS One. 2019 Jun 27;14(6):e0218879.
An S, Raju I, Surenkhuu B, Kwon JE, Gulati S, Karaman M, Pradeep A, Sinha S, Mun C, Jain S. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019 Apr 6. pii: S1542-0124(19)30051-5. PMID:
Accompanying editorial comment: Neutrophil Extracellular Traps (NETs) contribute to Pathological Changes of ocular Graft-vs.-Host Disease (oGVHD) Dry Eye: Implications for novel Biomarkers and Therapeutic Strategies by Seungwon An et al. Petricek I, Pavletic SZ. Ocul Surf. 2019 Jun 18. pii: S1542-0124(19)30222-8. PMID: 31226421.
Kalmodia S, Son K-N, Cao D, Lee B-S, Surenkhuu B, Shah D, Ali M, Balasubramaniam A, Jain S, Aakalu V. Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study. Sci Reports. Sci Rep. 2019 Jul 16;9(1):10304.
Kwon J, Surenkhuu B, Raju I, Atassi N, Mun J, Chen YF, Sarwar MA, Rosenblatt M, Pradeep A, An S, Dhall N, Mun C, Jain S. Pathological consequences of anti-citrullinated protein antibodies in tear fluid and therapeutic potential of pooled human immune globulin-eye drops in dry eye disease. Ocul Surf. 2020 Jan;18(1):80-97.
Accompanying editorial comment : Genschmer KR, Russel DW, Blalock JE. Too much of a good thing, how chronic neutrophilic inflammation can drive human disease. Ocul Surf. 2020 Apr;18(2):193-195.
Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report. Transplant Cell Ther. 2021 Jun 10:S2666-6367(21)00949-0. doi: 10.1016/j.jtct.2021.06.001. Epub ahead of print. PMID: 34217703.
Koujah L, Allaham M, Patil CD, Ames JM, Suryawanshi RK, Yadavalli T, Agelidis A, Mun C, Surenkhuu B, Jain S, Shukla D. Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies. Ocul Surf. 2021 Mar 22:S1542-0124(21)00015-X. doi: 10.1016/j.jtos.2021.03.005. Epub
ahead of print. PMID: 33766740.
Nair S, Vanathi M, Mukhija R, Tandon R, Jain S, Ogawa Y. Update on ocular graft-versus-host disease. Indian J Ophthalmol. 2021 May;69(5):1038-1050. doi: 10.4103/ijo.IJO_2016_20. PMID: 33913829.
Park RB, Jain S, Han H, Park J. Ocular surface disease associated with immune checkpoint inhibitor therapy. Ocul Surf. 2021 Apr;20:115-129. doi: 10.1016/j.jtos.2021.02.004. Epub 2021 Feb 19. PMID: 33610743.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transplant Cell Ther. 2021 Jul;27(7):545-557. doi: 10.1016/j.jtct.2021.03.033. Epub 2021 Apr 9. PMID: 33839317.
Katz EA, Sunshine S, Mun C, Sarwar M, Surenkhuu B, Pradeep A, Jain S. Combinatorial therapy with immunosuppressive, immunomodulatory and tear substitute eyedrops ("Triple Play") in Recalcitrant Immunological Ocular Surface Diseases. Ocul Surf. 2021 Nov 10;23:1-11. doi: 10.1016/j.jtos.2021.11.002. PMID: 34768002.