William Ackerman, MD
Research Associate Professor of Obstetrics & Gynecology,
Research Division
Academic Office:
Phone: (312) 996-3107
Fax: (312) 996-4238
|
Medical School |
Residency |
Postdoctoral |
|---|---|---|
| University of Cincinnati | Riverside Methodist Hospital | The Ohio State University |
Biography
Dr. Ackerman received his undergraduate degree in genetic bioengineering from Purdue University, and his M.D. degree from the University of Cincinnati College of Medicine. Having developed an interest in basic and translational research, he went on to complete postdoctoral training at The Ohio State University in Columbus, Ohio which was supplemented by a National Research Service Award (F32) fellowship from the Eunice Kennedy Shiver National Institute of Child and Human Development (NICHD).
For the past 20 years, Dr. Ackerman’s research interests have broadly focused on perinatal biology, including mechanisms of human parturition, syndromic pregnancy complications, and uteroplacental function. Special emphasis has been given to the utilization of cutting-edge computational methods to parse high-dimensional data derived from human tissues and in vitro experimental systems. Examples of recent and ongoing work include gene regulatory network modeling, correlative miRNA-mRNA interaction analysis, and the application of multi-omic data integration to delineate the contributions of somatic gene and transcriptional variations to divergences in canonical peptide sequences within clinical samples. Current research efforts are directed at bridging clinical phenotypes with molecular signatures in an effort to resolve potential disease subphenotypes in a data-directed manner.
Dr. Ackerman has been actively involved in the teaching and mentorship of numerous trainees from the undergraduate to the post-graduate level. He has co-authored over 48 peer-reviewed research articles, over 72 published scientific abstracts, and 2 book chapters, in addition to serving as referee for hundreds of submissions for 21 academic journals. He has received a teaching award for his contributions to The Ohio State University medical curriculum, and has regularly contributed to the education of clinical fellows in Maternal-Fetal Medicine.
Recent Publications
Jing H, Ackerman WE 4th, Zhao G, El Helou Y, Buhimschi CS, Buhimschi IA. Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU. Placenta. 2021 Jan 15;104:16-19.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfield TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological maturation of cerebral organoids correlates with dynamic morphological and cellular development. Stem Cell Reports. 2020 Oct 13;15(4):855-868.
Brockway HM, Kallapur SG, Buhimschi IA, Buhimschi CS, Ackerman WE 4th, Muglia LJ, Jones HN: Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births. PLoS One 2019;14:e0225062.
Beck S, Buhimschi IA, Summerfield TL, Ackerman WE, Guzeloglu-Kayisli O, Kayisli UA, Zhao G, Schatz F, Lockwood CJ, Buhimschi CS. Toll-like receptor 9, maternal cell-free DNA and myometrial cell response to CpG oligodeoxynucleotide stimulation. American Journal of Reproductive Immunology 2019; Feb 13:e13100.
Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. International Journal of Molecular Science 2018; 19(12): E3904.
Motawea HKB, Chotani MA, Ali M, Ackerman W, Zhao G, Ahmed AAE, Buhimschi CS, Buhimschi IA. Human Placenta Expresses α2-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction. American Journal of Pathology 2018; 188(12):2774-2785.
Rood KM, Buhimschi IA, Jurcisek JA, Summerfield TL, Zhao G, Ackerman WE, Wang W, Rumpf RW, Thung SF, Bakaletz LO, Buhimschi CS. Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery. Scientific Reports 2018; 8(1):8756.
Ackerman WE 4th, Buhimschi IA, Brubaker D, Maxwell S, Rood KM, Chance MR, Jing H, Mesiano S, Buhimschi CS. Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor. Biology of Reproduction 2018; 98(6):834-845.
Eidem HR, Rinker DC, Ackerman WE 4th, Buhimschi IA, Buhimschi CS, Dunn-Fletcher C, Kallapur SG, Pavlicev M, Muglia LJ, Patrick Abbot P, Rokas A: Comparing human and macaque placental transcriptomes to disentangle preterm birth pathology from gestational age effects. Placenta 2016; 41:74-82.
Ackerman WE 4th, Buhimschi IA, Eidem HR, Rinker DC, Rokas A, Rood K, Zhao G, Summerfield TL, Landon MB, Buhimschi CS: Comprehensive RNA profiling of villous trophoblast and decidua basalis in pregnancies complicated by preterm birth following intra-amniotic infection. Placenta 2016;44:23-33.
Ibrahim SA, Ackerman WE 4th, Summerfield TL, Lockwood CJ, Schatz F, Kniss DA: Inflammatory gene networks in term human decidual cells define a potential signature for cytokine-mediated parturition. American Journal of Obstetrics and Gynecology 2016;214:284.e1-284.e47.
For a list of Dr. Ackerman’s publications, please click the following link:
Research Funding
NIH/NICHD R01, “Misfoldome-centered MultiOMICS approach to unravel preeclampsia subphenotypes.” 2015-2020, Co-Investigator (PI: I. Buhimschi, University of Illinois at Chicago)