CLINICAL RESEARCHERS

Kirstie K. Danielson, PhD is an Assistant Professor in the Division of Endocrinology. Her research program broadly focuses on the reciprocal relationship between type 1 (i.e., juvenile) diabetes and diabetes-related complications such as bone, heart, and reproductive health.  Specifically, Dr. Danielson investigates the prevalence of risk factors for osteoporosis, cardiovascular disease, and altered reproductive function in patients both living with type 1 diabetes and after being functionally cured of type 1 diabetes via islet cell transplantation. In addition to the reciprocal impact of bone fragility/hormones, vascular function, and estrogen/sex differences on the ability of islet cell transplant to functionally cure type 1 diabetes.

Publications:

Rydzon B, Monson RS, Oberholzer J, Varady KA, Bellin MD, Danielson KK.  Long term (4 years) improved insulin sensitivity following islet cell transplant in type 1 diabetes.  Diabetes Metab Res Rev 2018; 34: e2972. PMCID: PMC5873303

Madrigal JM, Monson RS, Hatipoglu B, Oberholzer J, Kondos GT, Varady KA, Danielson KK.  Coronary artery calcium may stabilize following islet cell transplantation in patients with type 1 diabetes.  Clin Transplant 2017; 31: e13059. PMCID: PMC5633499

Marchese E, Rodeghier C, Monson RS, McCracken B, Shi T, Schrock W, Martellotto J, Oberholzer J, Danielson KK.  Enumerating β-cells in whole human islets: sex differences and associations with clinical outcomes after islet transplantation.  Diabetes Care 2015; 38: e176-e177. PMCID: PMC4613918

Kujath AS, Quinn L, Elliott ME, LeCaire TJ, Binkley N, Molino AR, Danielson KK.  Different health behaviors and clinical factors associated with bone mineral density and bone turnover in premenopausal women with and without type 1 diabetes.  Diabetes Metab Res Rev 2015; 31: 421-32. PMCID: PMC4406845

Dr. Yuval Eisenberg area of interest is in neuroendocrinology, specifically pituitary disorders, and in helping to characterize oxytocin derangement in patients who have hypopituitarism.  This is the last of the well-recognized pituitary hormones that we do not currently assess clinically and have no regular replacement strategies for now.  In addition, I am working with a colleague on an intervention study to assess whether oxytocin is an effective weight loss/diabetes prevention strategy.  Finally, I have interest in clinical research related to care of pituitary patients in general.  I am conducting clinical research projects looking at practice patterns for postoperative water balance in pituitary patients as well as assessing for surgical volume and outcomes in the chicagoland area.

1) Eisenberg, Y., Murad, S., Casagrande, A. et al. Oxytocin alterations and neurocognitive domains in patients with hypopituitarism, Pituitary (2019). https://doi.org/10.1007/s11102-019-00936-0 .

2) Eisenberg Y, Dugas LR, Akbar A, Reddivari B, Layden BT, Barengolts E. Oxytocin is lower in African American men with diabetes and associates with psycho-social and metabolic health factors.PLoS One. 2018 Jan 4;13(1):e0190301. doi: 10.1371/journal.pone.0190301. eCollection 2018

3) Barengolts E, Green SJ, Eisenberg Y, Akbar A, Reddivari B, Layden BT, Dugas L, Chlipala G., Gut microbiota varies by opioid use, circulating leptin and oxytocin in African American men with diabetes and high burden of chronic disease. PLoS One. 2018 Mar 29;13(3):e0194171. doi: 10.1371/journal.pone.0194171. eCollection 2018.

Dr. Dan Mihailescu is currently an Associate Professor at the Division of Endocrinology, Diabetes and Metabolism and the Director of the Endocrinology Fellowship Program. His clinical and research interests are in the areas of thyroid disorders, thyroid cancer and type 1 diabetes mellitus.

Selected recent publications:

  1. Shulan M, Vydro L, Schneider AB, Mihailescu D. Role of Biomarkers in Predicting the Occurrence of Thyroid Neoplasms in Radiation-Exposed Children. Endocrine-Related Cancer, 2018 Apr;25(4):481-491
  2. Martyn-Nemeth P, Phillips SA, Mihailescu D, et al. Poor sleep quality is associated with nocturnal glycaemic variability and fear of hypoglycaemia in adults with type 1 diabetes. J Adv Nur. 2018;74:2373–2380
  3. Sharp, L. K., Tilton, J. J., Touchette, D. R., Xia, Y., Mihailescu, D., Berbaum, M. L. and Gerber, B. S. Community Health Workers Supporting Clinical Pharmacists in Diabetes Management: A Randomized Controlled Trial. Pharmacotherapy, 2018, 38: 58–68

My research career has been focusing on the interrelationship between sleep, circadian and glucose metabolism. As an endocrinologist, I provide comprehensive clinical are for patients with type 1 and type 2 diabetes, as well as gestational diabetes. This led me to be interested in the relationship between sleep and circadian disturbances to glucose metabolism in disease populations, including type 1 and type 2 diabetes, prediabetes as well as gestational diabetes patients. Interventions to optimize sleep in order to improve glucose metabolism are being conducted.

  1. A. So-ngern, N. Chirakalwasan, S. Saetung, S. Chanprasertyptin, A. Thakkinstian, S. Reutrakul. Effects of sleep extension on glucose metabolism in chronically sleep-deprived individuals, Journal of Clinical Sleep Medicine, 2019, in press
  2. H. Nimitphong, A. Mahattanapreut ,La-or Chailurkit, S Saetung, N Siwasaranond, R. Sumritsopak, T. Anothaisintawee, A. Thakkinstian, L.R. Dugas, B.T. Layden, S. Reutrakul. More evening preference is positively associated with systemic inflammation in prediabetes and type 2 diabetes patients, Scientific Reports, 2018, Oct 26;8(1):15882. doi: 10.1038/s41598-018-34045-y
  1. Saetung, S. Reutrakul, LO Chailurkit, R. Rajatanavin, B. Ongphiphadhanakul, H. Nimitphong. The Association between Daytime Napping Characteristics and Bone Mineral Density in Elderly Thai Women without Osteoporosis. Sci Rep. 2018 Jul 3;8(1):10016. doi: 10.1038/s41598-018-28260-w.
  1. T. Anothaisintawee, D. Lertrattananon, S. Thammakaison, K.L. Knutson, A. Thakkinstian, S. Reutrakul. The relationship among morningness-eveningness, sleep duration, social jet lag and body mass index in Asian patients with prediabetes”, Frontiers in Endocrinology 2018https://doi.org/10.3389/fendo.2018.00435
  2. S. Saetung, H. Nimitphong, N Siwasaranond ,  R. Sumritsopak, P. Jindahra, O. Krairit, A. Thakkinstian, T. AnothaisintaweeS. Reutrakul. The relationship between sleep and cognitive function in patients with prediabetes and type 2 diabetes. Acta Diabetol. 2018 Sep;55(9):917-925. doi: 10.1007/s00592-018-1166-3.
  3. A. Kijmanawat, P. Panburana, S. Reutrakul, C. Tangshewinsirikul. The effects of probiotic supplements on insulin resistance in gestational diabetes mellitus: a double-blind randomized controlled trial, J Diabetes Invest 2018, May 20. doi: 10.1111/jdi.12863
  1. Nimitphong, N. Siwasaranond, S. Saetung, A. Thakkinstian, B. Ongphiphadhanakul, S. Reutrakul . The relationship among breakfast time, morningness-eveningness preference and body mass index in Type 2 diabetes. Diabet Med. 2018 35(7):964-971
  2. Reutrakul, E. Van Cauter. Sleep influences on obesity, insulin resistance, and risk of type 2 diabetes, 2018 Metabolism,Mar 3. pii: S0026-0495(18)30063-5. doi: 10.1016/j.metabol.2018.02.010
  1. S. Amnakkittikul, N. Chirakalwasan, E. Wanitcharoenkul, S. Charoensri, S. Saetung, S. Chanprasertyothin, L. Chailurkit, P. Panburana, S. Bumrungphuet, S. Reutrakul
    Postpartum Resolution of Obstructive Sleep Apnea in Women with Gestational Diabetes and the Relationship with Glucose Metabolism, Acta Diabetologica, 2018; 55(7):751-754.
  2. N. Siwasaranond, H. Nimitphong, A. Manodpitipong, S. Saetung, N. Chirakalwasan, A. Thakkinstian, S Reutrakul. The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes, Journal of Diabetes Research, 2018 Mar 7;9269170
  1. Lappharat, N. Taneepanichskul, S. Reutrakul, N. Chirakalwasan. Effects of Bedroom Environmental Conditions On The Severity of Obstructive Sleep Apnea, J of Clin Sleep Medicine, 2018;14(4):565-573
  2. Chirakalwasan , S. Amnakkittikul, E. Wanitcharoenkul, S. Charoensri, S. Saetung, S. Chanprasertyothin, L. Chailurkit, P. Panburana, S. Bumrungphuet, A. Thakkinstian, S. Reutrakul. Continuous Positive Airway Pressure Therapy in Gestational Diabetes with Obstructive Sleep Apnea: a Randomized Controlled Trial, J of Clin Sleep Medicine, 2018, 14(3): 327-336

INSTRUCTIONS: In order to add a sidebar anchor:

  1. Duplicate the existing item, listed as a 1/6 text field. (Or create a 1/6 column and add a text field, modify the class so it’s exactly “additionalAnchor”).
  2. Modify the text field inside the 1/6 column. Inside there, modify the HYPERLINK so that it would go to a corresponding section with a “#” in front of it. (Example, we have a “chief” section on the page, then it would make sense to have the hyperlink go to “#chief”)
  3. Then change the hyperlink TEXT to a appropriate label.
  4. IMPORTANT: If not done already, go into that CONTAINER that corresponds to your anchor (i.e. Meet The Chiefs), and add an ID matching the anchor’s HYPERLINK WITHOUT the “#”, i.e. “chief”.
  5. (If using side bar widget box, then there’s a saved copy of a widget box COLUMN, grab it in the column library, it should 1/6 of a length of a column.)

NOTE: Order added to the sidebar is from last to first.