Topical probiotic sinus irrigations for the treatment of recalcitrant chronic rhinosinusitis Amy De La Torre; Raktima Dasgupta, BS, MA; Omar Perez, PhD, PharmD; Victoria Lee, MD
Background: Infections in CRS may be related to a decrease in native and an increase in pathogenic bacteria. Topical probiotics outcompete pathogenic bacteria via a variety of mechanisms, including creating suboptimal environmental conditions, competing for cell surface receptors and thus limiting pathogen adherence, and producing antibacterial metabolites. In doing so, topical probiotics can restore [...]