Background: A cerebrospinal fluid (CSF) leak from the nose is termed CSF rhinorrhea. Forty percent of cases are idiopathic, meaning the cause is unknown. Numerous studies have demonstrated that the best way to repair CSF rhinorrhea is to utilize multiple layers of closure. Nevertheless, even after an optimal repair, some patients have persistent CSF rhinorrhea. There is a lack of information and understanding regarding the wound healing process involving CSF rhinorrhea.

Objectives: The aim of this preclinical study is to induce CSF rhinorrhea in a rat model, surgically repair the defect using various methods, and assess healing at specific time points. The results of the study will be used to gain a better understanding into the mechanism involved in CSF rhinorrhea repair