GEMS Faculty Listing 2017-07-28T14:44:15+00:00

GEMS Faculty Listing

 

Ackerman, Steven

Ph.D., McGill University
Professor of Biochemistry and Molecular Genetics
sackerma@uic.edu  312-996-6149

Research Interests
Gene Regulation , Lung Biology, Development

Research Description

Transcriptional mechanisms that regulate blood cell (granulocyte/eosinophil) lineage-specific development and gene expression during hematopoiesis. Cellular, molecular and immunobiology of the eosinophil granulocyte, focusing on pro-inflammatory effector functions in the pathogenesis of asthma and other allergic diseases such as eosinophilic esophagitis – mechanisms of eosinophil-mediated tissue damage, repair-remodeling and fibrosis are being investigated.

 

Art, Jonathan

Ph.D., University of Chicago
Associate Professor of Anatomy and Cell Biology
jart@uic.edu  312-996-4956

Research Interests
Bio-imaging , Cell and Membrane Biology, Neuroscience

Research Description

Biophysics of the Auditory and Vestibular Systems

 

Azar, Dimitri

M.D., American University of Beirut
Billie Alexander Field Chair of Ophthamologic Research, Professor and Department Head
dazar@uic.edu  996-6590

Research Interests
Vision Science , Neuroscience

Research Description

Corneal wound healing and matrix metalloproteinase.

 

Benevolenskaya, Elizaveta

Ph.D., Moscow State University, Russia
Associate Professor
evb@uic.edu 312-413-8947

Research Interests
Cancer Biology, Epigenetics

Research Interests

Function of tumor suppressors and oncogenes through interaction with chromatin and epigenetic factors. The role of these factors in the maintenance of metabolic state. Finding new molecular targets using system biology approaches.

 

Bongarzone, Ernesto R.

PhD, University of Buenos Aires
Assistant Professor of Anatomy and Cell Biology
ebongarz@uic.edu  312-996-6894

Research Interests
Cell and Membrane Biology

Research Description

Molecular and cellular mechanisms controlling endogenous remyelination; improving myelin repair with stem cell transplantation

 

Bonini, Marcelo

PhD
Assistant Professor
mbonini@uic.edu

Research Interests
Metabolism/Biochemistry , Signal Transduction and Cell Signaling, Biochemistry

Research Description

 

Bosland, Maarten

DVSc and PhD
Professor
boslandm@uic.edu

Research Interests
Cancer Prevention  and Carcinogenesis

Research Description

Prostate cancer prevention by naturally occurring agents and medicinal plants; Hormonal carcinogenesis (prostate cancer); Animal models of prostate cancer.

 

Bouvier, Marlene

Ph.D., McGill University
Associate Professor of Microbiology and Immunology
mbouvier@uic.edu  312-355-0664

Research Interests
Biochemistry , Molecular Biophysics and Structural Biology, Immunology

Research Description

An area of our research is focused on studying the class I antigen presentation pathway. The cell-surface presentation of antigens by class I MHC molecules is the culmination of an elaborated process that takes place in the endoplasmic reticulum (ER) and involves proteins such as tapasin, calreticulin, ERp57, and the transported associated with antigen processing. The characterization of these proteins and their functions is essential for elucidating the mechanistic basis of antigen selection in the ER. Another area of our research is to study the molecular basis of viral immune evasion mechanisms that operate by interfering with the class I antigen presentation pathway.

 

Brady, Scott

Ph.D., University of Southern California
Professor of Anatomy and Cell Biology
stbrady@uic.edu  312-996-6791

Research Interests
Neuroscience

Research Description

Molecular Mechanisms of Axonal Transport; Specialization of the Neuronal Cytoskeleton; Glial Modulation of Neuronal Function; and Effects of Physiological Stress on Neurons.

 

Brodie, Mark

Ph.D., University of Illinois at Chicago
Associate Professor of Physiology and Biophysics
mbrodie@uic.edu  312-996-2373

Research Interests
Cell Biology and Signaling

Research Description

Electrophysiology of dopamine neurons of the reward system of the central nervous system

 

Caffrey, Michael

Ph.D., University of Arizona
Associate Professor of Biochemistry and Molecular Genetics
caffrey@uic.edu  312-996-4959

Research Interests
Virology , Biochemistry, Molecular Biophysics and Structural Biology

Research Description

Study of viral entry mechanisms and their therapeutic intervention. Viruses under study include Ebola, Influenza, HIV and SARS.

 

Chakrabarty, Ananda

Ph.D, University of Calcutta
Distinguished University Professor, Microbiology & Immunology
pseudomo@uic.edu  312-996-4586

Research Interests
Microbiology , Cancer Biology

Research Description

Microorganisms and cancer; interaction of microbial redox proteins with the tumor suppressor protein p53; development of anticancer drugs from microbial sources.

 

Chan, Lawrence

M.D., University of Pennsylvania
Professor, Dermatology, Microbiology and Immunology
larrycha@uic.edu  312-996-1316

Research Interests
Virology , Immunology

Research Description

Molecular Mechanism of Chronic Skin Inflammation, Atopic Dermatitis.

 

Chen, Zheng

M.D., Ph.D., Peking Union Medical College
Professor of Microbiology and Immunology
zchen@uic.edu  312-355-0531

Research Interests
Immunology , Host-Pathogen Biology, Virology

Research Description

Fundamental immunology of antigen- specific gamma delta T cells; gamma delta T cell-based immunotherapeutics; MHC class I-restricted CD8+ CTL responses in TB and AIDS; Vaccine development for TB and AIDS; Immunopathogenesis in AIDS virus- mycobacterial coinfection; T cell- targeted biodefense.

 

Cho, Jaehyung “Gus”

PhD, University of Wisconsin-Madison
Associate Professor
thromres@uic.edu

Research Interests
Cardiovascular Biology , Immunology, Vascular Biology

Research Description
Mechanisms regulating platelet-neutrophil-endothelial cell interactions during thrombosis and inflammation; intravital microscopy in live animals.

 

Colamonici, Oscar

M.D., University of Uruguay
Associate Professor of Pharmacology
ocolamon@uic.edu  312-413-4113

Research Interests
Cell Cycle and Apoptosis , Cancer Biology

Research Description

Characterization of the structure of the interferon alpha receptor (IFN R) and cytokine signaling.

 

Colley, Karen

Ph.D., Washington University
Professor of Biochemistry and Molecular Genetics
karenc@uic.edu  312-996-7756

Research Interests
Cell and Membrane Biology , Biochemistry

Research Description

Control of glycoprotein biosynthesis during development and disease; mechanisms of Golgi protein trafficking and localization.

 

de Lanerolle, Primal

PhD, University of California, San Diego
Professor of Physiology and Biophysics and Medicine
Primal@UIC.edu  312-996-6430

Research Interests
Signal Transduction and Cell Signaling , Gene Regulation, Vascular Biology

Research Description

The cytoskeleton in signal transduction; Molecular motors in the nucleus

 

Diamond, Alan

PhD
Professor
adiamond@uic.edu

Research Interests
Cancer Biology , Cancer Prevention, Carcinogenesis

Research Description

Biological effects of the trace element selenium; Function and regulation of selenium-containing proteins; Role of anti-oxidant proteins in cancer risk and etiology

 

Diekwisch, Thomas

DDS, Ph.D. (sci), Ph.D. (phil), Philipps-University of Marburg, West Germany
Professor of Oral Biology and Adjunct Professor of Anatomy and Cell Biology
tomdkw@uic.edu  312-413-9683

Research Interests
Gene Regulation , Development

Research Description

Developmental, molecular, and evolutionary biology of tooth enamel and periodontium

 

Du, Xiaoping

M.D., Ph.D., University of Sydney, Australia
Professor of Pharmacology
xdu@uic.edu  312-355-0237

Research Interests
Vascular Biology , Signal Transduction and Cell Signaling

Research Description

Thrombosis, hemostasis, and vascular biology; molecular mechanisms and molecular pharmacology of platelet and endothelial cell functions.

 

Dudley, Samuel

MD, PhD, Medical College of Virginia, Richmond, VA
Chief, Division of Cardiology
scdudley@uic.edu  312-996-6730

Research Interests
Signal Transduction and Cell Signaling , Stem Cell Biology

Research Description

Structure, regulation, and pathophysiology of cardiac ion channels. Role of oxidative stress in atrial fibrillation. Developing tissue engineered approaches for cardiac cell replacement

 

Federle, Michael

Ph.D., Emory University
Assistant Professor of Microbiology and Immunology, Center for Pharmaceutical Biotechnology
mfederle@uic.edu  312-413-0213

Research Interests
Signal Transduction and Cell Signaling , Host-Pathogen Biology, Microbiology

Research Description

Cell-cell signaling in bacteria, a process termed Quorum Sensing. We are identifying the chemical signals and signaling pathways used by bacteria to control population-wide behaviors, which include their ability to cause disease in humans. Eventually we hope to discover means by which we can interfere with bacteria’s communication processes and ultimately alter the progression of bacterial infections.

 

Feinstein, Douglas

Ph.D., John Hopkins University
Research Professor of Anesthesiology, and Adjunct Professor of Anatomy and Cell Biology
dlfeins@uic.edu  312-355-1665

Research Interests
Neuroscience

Research Description

Molecular analysis of NOS2 expression and regulation by noradrenaline, PPAR agonists

 

Frasor, Jonna

PhD, University of Illinois at Chicago
Associate Professor of Physiology and Biophysics
jfrasor@uic.edu  312-355-2583

Research Interests
Cancer Biology , Signal Transduction and Cell Signaling

Research Description

Molecular mechanisms of hormone action. Estrogen receptor activity in breast cancer. Transcription factor crosstalk.

 

Freitag, Nancy

PhD, University of California at Los Angeles
Professor of Microbiology and Immunology
nfreitag@uic.edu  312-355-4903

Research Interests
Host-Pathogen Biology, Molecular Biology, Microbiology

Research Description

Functional characterization of host-pathogen interactions and deciphering how pathogenic intruders make themselves at home within mammalian cells. Determination of mechanisms of pathogen tissue tropisms. Exploration of how anesthetic agents can increase host susceptibility to microbial infection.

Frolov, Maxim

Ph.D, Moscow State University
Associate Professor of Biochemistry and Molecular Genetics
mfrolov@uic.edu  312-413-5797

Research Interests
Cell Cycle and Apoptosis , Gene Regulation, Genetics, Cancer Biology

Research Description

The role of E2F and pRB in normal and oncogenic proliferation. The function of the novel Hippo tumor suppressor pathway in Drosophila.

 

Fukai, Tohru

MD, PhD, Kyushu University, Fukuoka, Japan
Associate Professor of Medicine, Section of Cardiology, and Pharmacology
tfukai@uic.edu  312-996-6730

Research Interests
Gene Regulation , Molecular Biology, Vascular Biology

Research Description

To determine the role of oxidative stress and copper transport system in cardiovascular disease.

 

Gann, Peter

MD and ScD
Professor
pgann@uic.edu

Research Interests
Molecular Epidemiology , Cancer Prevention

Research Description

Prostate cancer prevention through dietary or anti-hormonal agents; Nuclear and architectural features of high-risk benign tissue in digital images; Biomarkers for breast cancer risk related to involution in benign tissue; Chemoprevention of liver cancer

 

Gaponenko, Vadim

PhD
Assistant Professor
vadimg@uic.edu

Research Interests
Biochemistry , Cancer Biology, Signal Transduction and Cell Signaling

Research Description

 

 

Gartel, Andrei

Ph.D., Institute of Virology, Moscow, Russia
Assistant Professor, Molecular Genetics, Microbiology and Immunology
agartel@uic.edu  312-996-1855

Research Interests
Cancer Biology , Cell Cycle & Apoptosis Gene Regulation, Gene Regulation

Research Description

Regulation of CDK inhibitor p21 in normal and cancer cells, Anticancer drugs that target antiapoptotic pathways

 

Hay, Nissim

PhD, Weizmann Institute, Israel
Professor of Biochemistry and Molecular Genetics
nhay@uic.edu  312-355-1684

Research Interests
Cancer Biology, Metabolism

Research Description

PI3K/Akt/mTORC1 signaling and cancer metabolism at the cellular and organismal levels

 

He, Bin

PhD, Purdue University
Associate Professor, Microbiology and Immunology
tshuo@uic.edu  312-996-2391

Research Interests
Virology , Host-Pathogen Biology, Immunology

Research Description

Viral pathogenesis and biology; regulation of innate immunity; viral vector and vaccine

 

Heyeman, Ahlke

PhD, University of Chicago
Assistant Professor of Physiology and Biophysics
ahlkeh@uic.edu  312-355-0259

Research Interests
Cardiovascular Biology

Research Description

Examining cardiac and pulmonary disease progression in muscular dystrophy. Determine disease progression by secondary mutations in other genes in both humans and mice.

 

Hu, Guochang

MD, PhD/China Medical University
Associate Professor, Pharmacology and Anesthesiology
gchu@uic.edu  (312) 996-4692

Research Interests
Lung Biology , Immunology, Vascular Biology

Research Description

Research description: Identify molecular regulatory mechanisms of innate immunity and inflammation, vascular endothelial barrier function, and acute lung injury/ARDS

 

Ikegaki, Naohiko

PhD, University of Pennsylvania
Visiting Associate Professor of Anatomy and Cell Biology
ikegaki@uic.edu

Research Interests
Cancer Biology , Gene Regulation, Neuroscience

Research Description

Biology and therapeutic approaches of neuroblastoma; functions of MYCN, EPH receptors, and ephrims in neuroblastoma

 

Kalyanasundaram, Ramaswamy

PhD, University of Calgary
Professor and Head, Microbiology and Immunology, Biomedical Sciences
ramswamy@uic.edu  815-395-5696

Research Interests
Immunology , Microbiology, Molecular Biology, Vaccine development

Research Description

Identify, characterize and evaluate vaccine potential of antigens and various adjuvants for developing vaccine against tropical parasitic infections.

 

Kaplan, Jack

PhD, London University
Benjamin Goldberg Professor & Head of Biochemistry & Molecular Genetics
kaplanj@uic.edu  312-355-2732

Research Interests
Biochemistry , Cell and Membrane Biology, Molecular Biophysics and Structural Biology

Research Description

Molecular characterization of P-type ATPases (Ion Pumps): structure- function relations, synthesis, assembly and trafficking. Mechanisms and Regulation of Copper transport in Human Cells.

 

Katzen, Alisa

PhD, University of California, San Francisco
Associate Professor of Biochemistry and Molecular Genetics
katzen@uic.edu  312-413-9215

Research Interests
Development , Genetics, Cell cycle & Apoptosis

Research Description

Molecular and genetic analysis of the coordination of cell cycle regulation and differentiation during development; functional role of a proto-oncogene.

 

Kenney, Linda

PhD, University of Pennsylvania
Professor Microbiology and Immunology
kenneyl@uic.edu  312-413-0576

Research Interests
Gene Regulation , Biochemistry, Microbiology

Research Description

Two-component signal transduction; Regulation of Salmonella pathogenicity Island 2 gene expression; Regulation of outer membrane proteins by EnvZ/OmpR

 

Kenter, Amy

PhD, Yeshiva (Albert Einstein College of Medicine)
Associate Professor Microbiology and Immunology
star1@uic.edu  312-995-5293

Research Interests
Immunology , Gene regulation

Research Description

Genetic mechanisms of immunoglobulin gene recombination; DNA-binding proteins; B cell specific nucleic enzymes; plasmid recombination assays.

 

Kozasa, Tohru

MD/PhD, University of Tokyo, Japan
Associate Professor of Pharmacology
TKozas@uic.edu  312-413-0111

Research Interests
Signal Transduction and Cell Signaling , Molecular Pharmacology, Neuroscience

Research Description

G-protein-mediated signal transduction pathways; Function of RGS proteins. Mechanism of regulation of Rho family GTPases (Rho, Rac, Cdc42) by G protein- coupled receptors.

 

LaDu, Mary Jo

PhD, University of Illinois at Chicago
Professor of Anatomy and Cell Biology
mladu@uic.edu  312 355-4795

Research Interests
Neuroscience, Molecular Pathology, Biochemistry

Research Description

The LaDu lab studies therapeutic strategies for Alzheimer’s disease (AD) using a unique transgenic mouse model developed in their lab.  Our current focus is understanding and targeting the interaction between sex and the different genotypes of APOE, as APOE4, a naturally occurring allele, is the greatest risk factor for AD, increasing risk up to 15-fold over the common APOE3 genotype.  Recent re-interpretaation of decades of human studies suggest that the risk imparted by APOE4 is actually specific only to females, introducing an important new direction for drug discovery.

​​

Lasek, Amy

Ph.D., Cornell University

alasek@uic.edu, 312-355-1593

Research Interests

Cell Biology and Signaling, Gene Regulation, Neuroscience

Research Description

Molecular and cell biology of alcoholism and cocaine addiction; sex differences in drug abuse.

 

Lau, Lester

Ph.D., Cornell University
Professor of Biochemistry and Molecular Genetics
lflau@uic.edu  312-996-7034

Research Interests
Cancer Biology , Cardiovascular Biology, Signal Transduction and Cell Signaling

Research Description

Tumor Angiogenesis, Cardiovascular Development, Extracellular Matrix Signaling, Aging

 

Lavie, Arnon

Ph.D., Brandeis University
Associate Professor of Biochemistry and Molecular Genetics
Lavie@uic.edu  312-355-5029

Research Interests
Molecular Biophysics and Structural Biology , Biochemistry

Research Description

Structure-based design of novel therapeutic agents by prodrug development and enzyme modifications. X-ray crystallographic structure determination of enzymes involved in prodrug activation.

 

Lazarov, Orly

Ph.D., Weizmann Institute of Science
Associate Professor of Anatomy and Cell Biology
olazarov@uic.edu  312-355-0548

Research Interests
Neuroscience , Biochemistry, Development

Research Description

Cellular and molecular mechanisms underlying Alzheimer’s disease; Misregulation of neurogenic processes in the AD brain; Neurogenesis and stem cell-based therapeutic approaches.

 

Le Breton, Guy

Ph.D., University of Chicago
Professor of Pharmacology
GCL@uic.edu  312-996-4929

Research Interests
Vascular Biology , Signal Transduction and Cell Signaling, Molecular Pharmacology

Research Description

Fundamental mechanisms and signal transduction processes involved in platelet activation and inhibition.

 

Lewandowski, E. Douglas

Ph.D., University of Texas Southwestern Medical School
Professor of Physiology and Biophysics, Director Program in Integrative Cardiac Metabolism
dougl@uic.edu  312-413-7261

Research Interests
Cardiovascular BioIogy , Metabolism/Biochemistry, Integrative Physiology

Research Description

Research explores the metabolic basis of cardiac dysfunction in heart disease. Focus is on metabolic flux regulation via enzyme expression using a novel combination of molecular techniques and magnetic resonance spectroscopy of the intact heart. Gene therapy, through the in vivo delivery of cardiac-specific, adenoviral constructs, enables the manipulation of enzyme expression and activity in animal models of heart disease. The program develops new methods for nuclear magnetic resonance (NMR) to detect intracellular transport rates and chemical reactions in intact, functioning tissues using new approaches for stable isotope kinetics in whole organs.

 

Liao, Xiubei

PhD
Associate Professor
xiubei@uic.edu

Research Interests
Biochemistry

Research Description

 

Liew, Chong Wee

Ph.D., University of Hamburg

Assistant Professor of Physiology & Biophysics

cwliew@uic.edu  312-413-1086

 Research Interests

Metabolism/Biochemistry, Cell Biology and Signaling, Gene Regulation

 Research Description

Our research aims to understand the metabolic effects of different adipose tissues including brown, visceral, subcutaneous and beige fat on systemic metabolic and energy homeostasis and pathologic conditions such as cardiovascular diseases and diabetes.

 Lipton, Howard L.

M.D., University of Nebraska
Professor, Neurology and Microbiology & Immunology
hlipton@uic.edu  312-996-5754

Research Interests
Molecular Virology, Viral Pathogenesis, Emerging Viral Discovery, Multiple Sclerosis

Research Description

Mechanistic studies of how a virus may persist in an animal host, inducing immunopathologic tissue damage, by focusing on the experimental demyelinating model of Theiler’s virus infection in mice. Also an unbiased approach is also being used to find a specific viral pathogen in multiple sclerosis without prior knowledge of the agent.

 

Liu, Yuru

Ph.D., John Hopkins University
Assistant Professor of Pharmacology
yuruliu@uic.edu 312-996-1202
Research Interests
Lung Biology, Stem Cell Biology
Research Description
Progenitor cell properties of alveolar type II cells

Lysakowski, Anna

Ph.D., University of Illinois at Chicago
Professor of Anatomy and Cell Biology
alysakow@uic.edu  312-996-5990

Research Interests
Neuroscience

Research Description

Ionic composition and synaptic innervation of hair cells. Efferent innervation of the vestibular periphery

 

Malik, A.B.

Ph.D., University of Toronto, Canada
Distinguished Professor and Head, Department of Pharmacology
abmalik@uic.edu  312-996-7635

Research Interests
Cell and Membrane Biology, Host-Pathogen Biology, Lung Biology, Molecular Pharmacology, Stem Cell Biology

Research Description

Gene regulation in endothelial cells; expression of adhesion molecules and their transcriptional regulation; regulation of endothelial transport; assembly of adherens junctions; function of caveolin-1 in endothelial cells.

 

Marucha, Phillip

PhD, University of Connecticut
Professor of Periodontics, Microbiology and Immunology
marucha@uic.edu  312-413-5902

Research Interests
Immunology , Microbiology

Research Description

Stress-Impaired Oxygen Dependent Transcription in Wounds; Distress, Saliva Composition, and Saliva Functions; Interdisciplinary Research in Cancer from an Oral Perspective; Modulation of Inflammation by Stress and Social Factors; Mechanisms of Neuroendocrine Regulation of Wound Healing During Aging

 

McLachlan, Alan

Ph.D., University of Aberdeen, Scotland
Professor, Medicine, Microbiology and Immunology
mclach@uic.edu  312-355-0211

Research Interests
Virology , Gene Regulation, Host-Pathogen Biology

Research Description

Regulation of hepatitis B virus transcription and replication

 

Mehta, Dolly

Ph.D., Delhi University, India
Assistant Professor of Pharmacology
dmehta@uic.edu  312-355-0236

Research Interests
Vascular Biology , Signal Transduction and Cell Signaling, Cell and Membrane Biology

Research Description

Rho regulation of actin polymerization.

 

Merrill, Brad

Ph.D., University of California, San Diego
Assistant Professor of Biochemistry and Molecular Genetics
merrillb@uic.edu  312-996-0346

Research Interests
Cancer Biology , Development, Stem Cell Biology

Research Description

We examine how transcription factors determine cell fates, with a particular focus on effects on stem cells and during carcinogenesis.

 

Minshall, Richard

Ph.D., University of Illinois at Chicago
Professor of Pharmacology and Anesthesiology
Director, Research Resources Center
rminsh@uic.edu  312-996-1655

Research Interests

Endothelial Cell Signaling, Mechanisms of Cardiovascular and Pulmonary Disease

Research Description

The Minshall lab is focused on defining mechanisms that regulate caveolae trafficking dynamics and how caveolin-1, the defining protein constituent of caveolae, influence microvascular permeability as well as lung endothelial and epithelial cell homeostasis and repair mechanisms. The lab also studies caveolin-1 regulated inflammatory signaling involved in PMN adhesion, transmigration, and acute lung injury. The objectives of the research are to define the signaling mechanisms of inflammatory hyperpermeability and dysfunction of the vascular endothelium and airway epithelium.

 

Morfini, Gerardo

Ph.D., National University of Cordoba, Argentina.

gmorfini@uic.edu    312-996-6869

Research Interests

Neuroscience, Biochemistry, Signal Transduction and Cell Signaling, Cell Biology and Signaling

Research Description

Our research program addresses basic molecular mechanisms underlying the regulation of axonal transport (AT), a specialized form of intracellular trafficking in neuronal cells. Relevant to the Biomedical field, our studies aim to shed light on pathogenic mechanisms by which AT deficits promote loss of axonal connectivity in several adult-onset neurodegenerative diseases including Huntington’s disease, Amyotrophic Lateral Sclerosis, and Parkinson’s disease.

 

Naba, Alexandra

Ph.D, Curie Institute, Paris France
Assistant Professor, Department of Physiology and Biophysics
anaba@uic.edu   312-355-5417

Research Interests
Cancer Biology, Cell Biology and Signaling, Proteomics

Research Description

My laboratory studies the role of the extracellular matrix (ECM) in development, health, and disease, with a particular focus on cancer. To do so, we utilize classical molecular, cellular, and developmental biology approaches in combination with cutting-edge proteomics and computational analyses. Our goal is to better understand how the ECM contributes to diseases so that we can exploit it to develop novel diagnostic and therapeutic strategies.

Nakamura, Toru

Ph.D, University of Colorado, Boulder
Associate Professor of Biochemistry and Molecular Genetics
nakamut@uic.edu  312-996-1988

Research Interests
Biochemistry, Genetics, Cell Cycle & Apoptosis, Signal Transduction and Cell Signaling, Molecular Biology, Cancer Biology, Gene Regulation, Genetics and Genomics

Research Description

Our laboratory is interested in understanding how checkpoint and DNA repair proteins contribute to maintenance of telomeres, the natural ends of linear eukaryotic chromosomes. Deregulation of telomere maintenance mechanisms has been found to be a key event in tumorigenesis, and mutations that cause defects in telomere protection and/or replication have been linked to various human diseases with pre-mature aging phenotypes due to depletion of stem cells. We are currently focusing our efforts in understanding how post-translational modifications, such as phosphorylation and SUMOylation, contribute to telomere maintenance in fission yeast since fission yeast and mammalian cells use very well conserved sets of protein complexes to regulate telomere protection and replication.

 

Nieto, Natalia

Pharm.D., PhD
Professor of Pathology
nnieto@uic.edu

Research Interests
Cell Biology and Signaling, Metabolism/Biochemistry, Signal Transduction and Cell Signaling

Research Description

 My laboratory focusses on the role of extracellular matrix proteins and inflammatory mediators in the pathogenesis of chronic liver disease. Specifically, we study the molecular mechanisms contributing to the progression and resolution of alcoholic hepatitis, non-alcoholic steatohepatitis, liver fibrosis and hepatocellular carcinoma.

Nonn, Larisa

PhD, University of Arizona
Associate Professor of Pathology
lnonn@uic.edu  312-996-0194

Research Interests
Cancer Biology , Cell Biology and Signaling, Gene Regulation

Research Description

We use human pre-clinical model systems and patient specimens to  learn about prostate biology to gain insight into carcinogenesis and potential prevention strategies.  Projects include prostate cancer prevention by vitamin D, the role of microRNAs in prostate carcinogenesis, and serum microRNAs as prognostic biomarkers for prostate cancer.

 

O Donnell, Michael

PhD, The Ohio State University
Associate Professor of Physiology and Biophysics
odonnell@uic.edu  312-413-8276

Research Interests
Cardiovascular Biology , Metabolism/Biochemistry, Integrative Physiology

Research Description

Biochemistry, physiology, and molecular biology studies integrating cardiac metabolism, calcium handling, and enzyme expression in heart disease. Utilizing methods of NMR spectroscopy, fluorescence microscopy, and in vivo gene transfer.

 

O’Bryan, John P.

Ph.D., University of North Carolina at Chapel Hill
Associate Professor of Pharmacology and GEMS Co-Director
obryanj@uic.edu  312-996-6221

Research Interests
Signal Transduction and Cell Signaling , Cell and Membrane Biology, Neuroscience

Research Description

The research in the lab is focused on the role of scaffolding proteins in the regulation of signal transduction pathways, protein ubiquitylation, trafficking and endocytosis.

 

Pandey, Subhash

Ph.D., Central Drug Research Institute
Professor of Psychiatry, Anatomy and Cell Biology
scpandey@uic.edu  312-569-7418

Research Interests
Neuroscience , Signal Transduction and Cell Signaling

Research Description

Molecular and cellular neurobiology of alcohol and drug addiction.

 

Park, Changwon

PhD
Assistant Professor
pcwkyh17@uic.edu

Research Interests
Development , Stem Cell Biology, Vascular Biology

Research Description

To study the biology of vascular endothelial cells with mouse genetics and embryonic stem (ES) cells.

 

Pepperberg, David R.

Ph.D.
Professor of Ophthamology & Visual Sciences, Physiology & Biophysics, Biochemistry & Molecular Genetics
davipepp@uic.edu  996-4262

Research Interests
Vision Science , Neuroscience

Research Description

Development of nanoscale neuromodulating platforms as a therapy for retinal degenerative diseases.

Retinal electryphysiology and biochemistry.

 

Phan, K. Luan

M.D., University of Michigan

klphan@uic.edu  312-355-5954

Research Interests

Human Cognitive and Affective Neuroscience; Neuropsychopharmaoclogy; Neuromodulation

Research Description

Functional Neuroimaging (fMRI, EEG) of Anxiety, Depression, Interventions and Drug Effects

 

Popov, Sergey

Ph.D., Moscow State University
Associate Professor of Physiology and Biophysics
spopov@uic.edu  312-413-5682

Research Interests
Neuroscience , Signal Transduction and Cell Signaling

Research Description

 

Prabhakar, Bellur

Ph.D., Johns Hopkins University
Professor, Microbiology & Immunology
Bprabhak@uic.edu  312-996-1831

Research Interests
Cell cycle and Apoptosis , Immunology, Cell and Membrane Biology

Research Description

Role of regulatory T cells in autoimmunity, Molecular mechanisms of actions of IG20 splice variants that can promote either apoptosis or cell- growth. Therapeutic interventions against SARS.

 

Qian, Haohua

Ph.D.
Associate Professor of Ophthamology and Vision Sciences
hqian@uic.edu  413-7347

Research Interests
Vision Science , Neuroscience, Signal Transduction and Cell Signaling

Research Description

Cellular and molecular basis of signal processing in the retina.

 

Qu, Tingyu

M.D., Ph.D., Kobe university School of Medicine, Japan
Research Assistant Professor of Psychiatry, and Adjunct Assistant Professor of Anatomy and Cell Biology
tqu@uic.edu  312 355-1786

Research Interests
Stem Cell Biology

Research Description

Therapeutic potential of human stem cells in neurodegenerative diseases

Rao, Mrinalini

Ph.D., University of Michigan
Professor of Physiology and Biophysics
meenarao@uic.edu  312-996-7884

Research Description

Cellular and molecular basis of regulating salt and water transport across epithelia

 

Rasenick, Mark

Ph.D., Wesleyan University
Professor of Physiology and Biophysics, and Psychiatry
raz@uic.edu  312 996 6641

Research Interests
Neuroscience , Signal Transduction and Cell Signaling

Research Description

G protein signaling and the cytoskeleton; regulation of synaptic shape by neurostranmitters; molecular biology of depression

 

Raychaudhuri, Pradip

Ph.D., Albert Einstein College of Medicine
Professor of Biochemistry and Molecular Genetics
pradip@uic.edu  312-413-0255

Research Interests
Cancer Biology, Gene Regulation, Stem Cell Biology

Research Description

My laboratory studies liver, breast and colon cancers using mouse models to understand the molecular basis of high-grade metastatic progression. FoxM1 and DDB2 are being studied intensely to investigate how they regulate differentiation of cancer cells, in vitro and in vivo. The lab is also investigating the roles of these two genes on the development and survival of cancer stem/progenitor cells.

 

Rehman, Jalees

MD
Associate Professor
jalees@uic.edu

Research Interests
Stem Cell Biology , Vascular Biology, Metabolism/Biochemistry

Research Description

My laboratory studies the biology of regenerative stem and progenitor cells in the cardiovascular system.

 

Rong, Lijun

Ph.D., Purdue University
Professor, Microbiology and Immunology
lijun@uic.edu  312-355-0203

Research Interests
Virology , Microbiology, Host-Pathogen Biology

Research Description

Research description: My laboratory research is focused on elucidating the entry mechanisms of a number of important human viral pathogens, particularly emerging viral pathogens such as Ebola/Marburg viruses, influenza viruses, HIV, and  arenaviruses, and on developing antivirals. We use high-throughput screening and other approaches to discovering the host factors involved in viral infection and new  antiviral drugs.

 

Ross, Susan

Ph.D.,  Princeton University
Professor and Head, Microbiology and Immunology
srross@uic.edu  312-996-4945

Research Interests
Genetics, Immunology and Virology

Research Description

Genetics of host-virus interactions, particularly retroviruses and new world arenaviruses; innate and intrinsic immunity to virus infection; mouse models of breast cancer.

 

Russell, Brenda

PhD, University London, UK
Professor of Physiology and Biophysics
russell@uic.edu  312 413 0407

Research Interests
Molecular Physics and Structural Biology. Molecular and Integrated Cardiac Biology , Signal Transduction and Cell Signaling

Research Description

Physiology and Biophysics, of the heart cells by molecular, bioengineering, cells biology and imaging approaches.

 

Segev, Nava

Ph.D.
Professor, Biochemistry and Molecular Genetics
nava@uic.edu 312-355-0142

Research Interests

Cell and Membrane Biology, Genetics, Molecular Biology

Research Description

Regulation of Intracellular Trafficking by Molecular Switches and Cascades:  The Role of Ypt/Rab GTPases.

Shahidi, Mahnaz

Ph.D.
Professor, Ophthamology & Visual Sciences and Bioengineering
mahnshah@uic.edu  413-7364

Research Interests
Bio-imaging , Vision Science

Research Description

Development of optical imaging systems for quantitative assesment of eye diseases.

Sharma Kamal

Ph.D
Associate Professor of Anatomy and Cell Biology
kamalsha@uic.edu 312-413-0072
Research Interests
Neuroscience, Genetics, Development
Research Description

To develop genetic and developmental strategies for understanding the neural control of motor behaviors in mammals. Neuronal cell fate decisions and their functional consequences. Developmental, genetic regulation of dopamine neuron diversity.

Sharma, Ragiv P.

MD. Osmania University, and the Mount Sinai Medical Center, NY, NY.

rsharma@uic.edu 312-413-4508

Research Interests

Gene Regulation, Neuroscience, Molecular Pharmacology

 Research Description

Molecular mechanisms in epigenetic regulation in the brain in schizophrenia and bipolar disorder.

Shikano, Sojin

PhD
Associate Professor
sshikano@uic.edu

Research Interests
Cell and Membrane Biology

Research Description

Molecular mechanisms underlying the intracellular trafficking of membrane proteins

Shin, Jae-Won

PhD
Assistant Professor of Pharmacology and Bioengineering

shinjw@uic.edu

Research Interests

Stem Cell Biology, Cellular and Molecular Biophysics, Biomaterials

Research Description

Our laboratory aims to improve regenerative therapeutics by biophysical modulation of blood and immune cells. We are exploring how biophysical forces, such as matrix mechanics and shear force, regulate cell-cell and cell-environment communications. We are also developing physical approaches to biomaterial design to facilitate cell-based and cell-inspired regeneration across different scales.


​​

Shukla, Deepak

Ph.D., University of Illinois at Chicago
Associate Professor, Ophthalmology & Visual Sciences and Microbiology & Immunology
dshukla@uic.edu  312-355-0908

Research Interests
Virology , Host-Pathogen Biology, Vision science

Research Description

Molecular basis for viral entry; mouse model for ocular herpes

 

Simonovic, Miljan

PhD., University of Illinois at Chicago
Associate Professor of Biochemistry and Molecular Genetics
msimon5@uic.edu 312-996-0059

Research Interests
Molecular Biophysics and Structural Biology , Biochemistry

Research Description

The main areas of our research program are: (i) mechanisms regulating fidelity of gene translation, (ii) structure and function of aminoacyl-tRNA synthetases and other tRNA-dependent enzymes, (iii) mechanisms governing genetic code reassignment events, and (iv) the role of selenium, selenocysteine and selenoproteins in fundamental biological processes.

 

Skidgel, Randal

Ph.D., University of California, San Diego
Professor of Pharmacology
rskidgel@uic.edu  312-996-9179

Research Interests
Molecular Pharmacology , Vascular Biology, Signal Transduction and Cell Signaling

Research Description

Role of peptidases in the regulation of G protein-coupled receptor signaling and the function of nitric oxide synthases in vascular disease.

 

Smalheiser, Neil

MD, PhD
Associate Professor
neils@uic.edu

Research Interests
Bioinformatics, Neuroscience

Research Description

Role of small RNAs in neuronal function and synaptic plasticity. Text and data mining.

 

Solaro, R. John

Ph.D., University of Pittsburgh
Distinguished University Professor, Department of Physiology and Biophysics
solarorj@uic.edu  312-996-7620

Research Interests
Molecular and Integrated Cardiac Biology , Signal Transduction and Cell Signaling, Molecular Biophysics and Structural Biology

Research Description

Integrated Molecular, Structural, and Cellular Biology of Heart Muscle Physiology, Pathology, and Pharmacology

 

Stocco, Carlos

PhD, University of San Luis, San Luis, Argentina
Associate Professor of Physiology and Biophysics
costocco@uic.edu  312-355-0150

Research Interests
Cancer Biology , Signal Transduction and Cell Signaling

Research Description

Molecular Pathways Controlling Ovarian Gene Expression.

 

Tamplin, Owen

Assistant Professor of Pharmacology
otamplin@uic.edu 312-355-1138

Research Interests
Development, Stem Cell Biology and Hematopoiesis

Research Description

In the Tamplin lab we study hematopoietic stem cells (HSCs) and how they communicate with their niche microenvironment. HSCs are clinically relevant because they can be transplanted as a curative treatment for many blood cancers and diseases. We use the complementary strengths of the zebrafish and mouse model organisms, and our experimental approaches integrate genetic tools, live imaging, and chemical biology

 

Tang, Xao X.

PhD, University of Pennsylvania
Assistant Professor of Anatomy and Cell Biology
xaotang@uic.edu

Research Interests
Cancer Biology , Neuroscience

Research Description

Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma

 

Tao, Lin

D.D.S., Ph.D., University of Connecticut
Associate Professor, Microbiology and Immunology,
ltao@uic.edu  312-355-4077

Research Interests
Host-Pathogen Biology , Microbiology

Research Description

Microbial genetics of streptococci and lactobacilli

 

Tiruppathi, Chinnaswamy

Ph.D., University of Madras
Associate Professor of Pharmacology
tiruc@uic.edu  312-355-0249

Research Interests
Vascular Biology , Cell and Membrane Biology

Research Description

Our primary research interest is to study the molecular mechanism that regulates vascular inflammation. Pro- inflammatory mediator thrombin induces vascular inflammation by cleaving the endothelial cell surface protease activated receptor-1 (PAR-1). PAR-1 activation causes vascular leakage and neutrophil adhesion-mediated vascular injury. Ca2+ signaling plays an important role in the mechanism of thrombin-induced vascular injury. Currently, we are investigating how thrombin increases intracellular Ca2+ by opening plasma membrane transient receptor potential channels expressed in endothelial cells. In addition, we are also investigating the role of Ca2+ signaling in the mechanism of nuclear factor ?B (NF-?B) activation- dependent expression of inflammatory genes in endothelial cells.

 

Tyner, Angela

Ph.D. University of Chicago
Professor of Biochemistry and Molecular Genetics
atyner@uic.edu  312-996-7964

Research Interests
Signal Transduction and Cell Signaling , Cell cycle & Apoptosis, Cancer Biology

Research Description

Regulation of epithelial cell differentiation; Cell cycle regulation in regenerating tissues; Cancer

 

Ucker, David

Ph.D., University of California, San Francisco
Professor, Microbiology and Immunology
duck@uic.edu  312 413 1102

Research Interests
Immunology , Cell Biology and Signaling, Signal Transduction and Cell Signaling

Research Description

Mechanism and regulation of the processes of physiological cell death and the innate immune recognition and non-inflammatory clearance of cell corpses.

 

Ushio-Fukai, Masuko

PhD, Kyushu University, Fukuoka, Japan
Associate Professor of Pharmacology
mfukai@uic.edu  312-996-7665

Research Interests
Cell Biology and Signaling, Signal Transduction and Cell Signaling, Vascular Biology,

Cancer Biology, Cardiovascular Biology

Research Description

To determine the role of reactive oxygen species in angiogenesis and cardiovascular diseases using cell culture, live cell imaging, cell fractionation, molecular and cell biological analysis as well as in vivo models with knockout and transgenic mice.

 

Volz, Karl

Ph.D., University of California, San Diego
Associate Professor of Microbiology and Immunology
kvolz@uic.edu  312 996 2314

Research Interests
Molecular Biophysics and Structural Biology, Biochemistry, Microbiology

Research Description

Protein structure and function

 

Walden, William

Ph.D., Washington University
Professor, Microbiology and Immunology
wwalden@uic.edu  312-996-8576

Research Interests
Biochemistry , Gene Regulation

Research Description

Mechanisms of iron regulation and FeS cluster assembly; translational mechanisms and regulation.

 

Walsh Michael John

Ph.D, University of Illinois at Chicago
Assistant Professor of Pathology
walshm@uic.edu  312-996-9684

Research Interests
Bio-Imaging, Bioinformatics

Research Description

My research lab, the Spectral Pathology Lab, is focused towards developing new chemical imaging tools, such as mid-infrared spectroscopic imaging, to provide novel biochemical information to Pathologist and basic scientists to; 1) Guide tissue diagnostic and prognostic decisions where current techniques are lacking, 2) Gain new biochemical insight in to key cell and tissue processes that will improve our understanding of disease, and 3) Develop the methodology, instrumentation, software and computational approaches to make Chemical Imaging accessible and useful for non-experts in the healthcare field.

Wary, Kishore K.

PhD, North Eastern Hill University, India
Assistant Professor of Pharmacology
kkwary@uic.edu  312-413-9582

Research Interests
Wnt Signaling , Stem Cell Biology, Chemical Biology

Research Description

Our laboratory is interested in the biology of Wnt/beta-catenin signaling that is known to regulate heart and vascular development, and functions in cardiac hypertrophy and tissue remodeling after injury in the adult heart. We use molecular genetics and chemical biology approaches to address unanswered questions of cardiovascular disease. To address these questions, we use stem and iPS cells, and transgenic mice.

 

Wolf, William

Ph.D., George Washington University
Research Scientist, Edward Hines, Jr. VA Hospital and Adjunct Associate Professor of Anatomy and Cell Biology
william.wolf@med.va  708-202-8387

Research Interests
Neuroscience

Research Description

Neurochemical and behavioral analysis of neural plasticity related to neurological/psychiatric disorders and their treatment

 

Wolska, Beata

Ph.D., Postgraduate Center of Medical Education, Warsaw, Poland
Associate Professor of Physiology in Medicine
bwolska@uic.edu  312-413-0240

Research Interests
Molecular and Integrated Cardiac Biology , Signal Transduction and Cell Signaling

Research Description

Role of calcium and myofilaments in controlling cardiac function.

 

Wright, Margaret E.

Ph.D., Yale University
Assistant Professor of Pathology
mewright@uic.edu  312 -996-9684

Research Interests
Molecular Epidemiology , Cancer Prevention, Genetics/Genomics

Research Description

I combine population-based (epidemiologic) and laboratory approaches to study the effects of dietary and other lifestyle factors on the etiology of prostate and lung cancers. I also examine how genetic susceptibility modifies associations between these factors and cancer risk.

 

Ye, Richard

M.D., Ph.D., Washington University
Professor of Pharmacology, Microbiology & Immunology
yer@uic.edu  312-996-5087

Research Interests
Immunology, Molecular Pharmacology, Host-Pathogen Biology

Research Description
Major research interests are focused on how immune cells recognize microbial and host-derived factors and mount an effective immune response, and how therapeutic agents (drugs) may be develop based on the understanding of the signaling mechanisms inside inflammatory and immune cells.

 

Yuan, Jason

MD, PhD
Professor
jxyuan@uic.edu

Research Interests
Vascular Biology , Signal Transduction and Cell Signaling, Cell and Membrane Biology

Research Description

Pathogenic mechanisms of pulmonary arterial hypertension; ion channel electrophysiology; calcium signaling; hypoxic pulmonary vasoconstriction; smooth muscle cell migration, proliferation and apoptosis; stem cell proliferation and differentiation.

 

Yue, Beatrice

Ph.D.
Professor, Ophthamology and Visual Sciences
beatyue@uic.edu  996-6125

Research Interests
Gene Regulation , Vision Science

Research Description

Biochemical and molecular basis of keratoconus; studies of glaucoma genes.

 

Zhao, You-Yang

PhD
Professor of Pharmacology
yyzhao@uic.edu  312-355-0238

Research Interests

Lung Biology, Vascular Biology, Signal Transduction and Cell Signaling

Research Description

Mechanisms of endothelial regeneration and resolution of inflammatory injury in sepsis and acute respiratory distress syndrome. Molecular basis of pulmonary vascular remodeling and pulmonary hypertension. Focus on endothelial cell biology but also study the crosstalk between endothelial cells and other cells such as macrophages, smooth muscle cells, and stem/progenitor cells.

 

Zhou, Guofei

Ph.D., University of South Alabama
Assistant Professor of Pediatrics
guofei@uic.edu 312-355-0073

Research Interests
Lung Biology, Signal Transduction and Cell Signaling, Cancer Biology

Research Description
Hypoxia signaling, epithelial-mesenchymal transition, drug discovery, animal models of human diseases