The study of elucidation of the nature of biological phenomena and disease states through focused examination of the activity, function, and structure of biomolecules. Research is carried out at the molecular level through the study of DNA, RNA, proteins, and other macromolecules involved in genetic and cellular function.
Faculty members are investigating the causes of cancer, as well as ways to prevent and treat the disease. A variety of model organisms and human clinical samples are being used to explore the molecular, genetic, and cellular events that contribute to the initiation, progression, and metastasis of cancer. Faculty are also pursuing the discovery of novel strategies to reduce cancer progression and mortality.
Study of the organ system that uses the heart to pump blood throughout the body. Basic biological and translational research spans the spectrum of biophysical, molecular, cellular, whole animal, and human translational trials to elucidate normal cardiovascular physiology and define underlying pathophysiology of cardiovascular disease.
The study of biological process by which organisms grow and develop. This field of science brings together a diverse group of disciplines and technologies aimed to understand the behavior of cells and of how these cells interact to assemble tissues, organs, and a whole organism.
The study of heredity of traits via the passage of DNA sequences and DNA-sequence independent (i.e. epigenetic) mechanisms. Fields of study range from populations of organisms – to individual organisms – to cells within organisms, and examine various effects on normal biology and disease states.
The study of the normal immune system and immunological dysregulation that results in autoimmune diseases such as Type-1 diabetes, systemic lupus erythematosus, rheumatoid arthritis, etc and identify means to correct them. Studies involve basic and applied immunology raging from antigen presentation by dendritic cells, T and B cell repertoire selection and differentiation, and the role of chemokines and cytokines.
Interdisciplinary research that uses computer science, statistics, mathematics and engineering to analyze large datasets of biological information. A focus on genetic and epigenetic data at the whole genome and multi-genomes-level are applied to elucidate new understanding in diverse basic biological and translational fields of study.
The study of the lung in health and disease from cells to the organismic level. Research encompasses the gas exchange function of lungs at the level of epithelial cells, role of lung as an essential host-defense and immune organ, properties of the vasculature including endothelial cells lining blood vessels and vascular smooth cells in maintaining tissue homeostasis, and mechanisms of repair and tissue regeneration through identification of specific stem cell populations.
Combines examination at cellular and organismal levels of the process by which energy is provided, stored, and utilized for vital processes and activities. Research encompasses many aspects of molecular, biochemical, genetic, and physiological effects of metabolic processes especially in diseases that critically involve metabolism, including cancer, diabetes, hypertension, obesity, and liver diseases.
The study of the biology, transmission, pathogenesis and treatment of viruses, bacteria, and other microorganisms important for human disease, together with the host response to microbial infection.
The study of the nervous system, its structure and function, its effects on behavior and homeostatic control, as well the study of its pathologies – from disorders of the mind to neurodegeneration associated with aging, disease, trauma and genetic susceptibility.
The biology of adult stem cells, embryonic stem cells, induced pluripotent stem cells and the study of adult tissue regeneration. Fields of study range from defining the basic biological mechanisms of stem cell function using cell biology and molecular biology to applying insights derived from stem cells in disease settings such as hematopoiesis, neurodegenerative disease, cancer, cardiovascular disease, lung disease or acute and chronic inflammation.
The study life processes at the molecular level.
Topics under study include: (1) protein, DNA or RNA structure, (2) protein-protein, protein-DNA or protein-RNA interactions, (3) drug discovery and optimization. Techniques utilized include X-ray
Crystallography, NMR Spectroscopy, High Speed Computer Clusters, and High Resolution Fluorescence.
The study of normal body function, critical for understanding human health. The focus is on how individual organ systems integrate molecular and cellular components into function and how different organs cooperatively function to maintain homeostasis. Studies examine how the complex interactions of endocrine, reproductive, circadian, immune, metabolic, mechanical and neuronal signals, maintain a steady-state internal environment. This knowledge forms the basis for understanding dysregulated body function leading to cancer, cardiovascular disease, dementia, and renal, gastrointestinal, and metabolic disorders.
The study of the life cycles of viruses and their effects on infected hosts. Viral life cycles include entry, genome release from the virus particles, genome replication, viral protein synthesis, viral assembly and egress from the infected cells. Infections can be acute, chronic or latent depending on the host-pathogen interactions which include direct cytopathic effects plus immune mediated modulation of virus biosynthesis and disease.