Quantitative Ocular Genomics Laboratory
Xiaoyi “Raymond” Gao, PhD, Director
Associate Professor of Ophthalmology
Research Interest: Vision disorders, human genetics, statistical genomics, and bioinformatics.
Ongoing Research: Current investigations include the Mexican American Glaucoma Genetic Study (MAGGS), which aims at identifying genetic determinants related to open angle glaucoma in Mexican Americans, and investigations into the genetics of diabetic retinopathy and age-related macular degeneration in admixed and minority populations.
Impact: Discoveries in ocular genomics will extend our understanding of eye diseases/traits by identifying relevant genetic variants, genes and pathways, thereby potentially leading to early detection and effective treatment of many eye disorders which can lead to blindness.
Office Location: 1905 W Taylor Street, Room 235
Mailing Address: 1855 W Taylor Street, M/C 648, Chicago, IL 60612
Gao X, Gauderman WJ, Liu Y, Marjoram P, Torres M, Haritunians T, Kuo JZ, Chen YI, Allingham RR, Hauser MA, Taylor KD, Rotter JI, Varma R. (2013) A genome-wide association study of central corneal thickness in Latinos. Investigative Ophthalmology & Visual Science (in press).
Gao X, Haritunians T, Marjoram P, Mckean-Cowdin R, Torres M, Taylor KD, Rotter JI, Gauderman WJ, Varma R. (2012) Genotype imputation for Latinos using the HapMap and 1000 genomes project reference panels. Front Genet 3:117.
Gao X, Edwards TL. (2011) Genome-wide association studies: Where we are heading? World J Med Genet 1(1):1-000 doi:10.5496/wjmg.v1.i1.1.
Gao X. (2011) Multiple testing corrections for imputed SNPs. Genetic Epidemiology 35:154-8.
Gao X and Edwards TL. (2010) Population stratification, adjustment for. Encyclopedia of Life Sciences DOI: 10.1002/9780470015902.a0020384.
Gao X, Becker LC, Becker DM, Starmer J, Province MA (2010) Avoiding the high Bonferroni penalty in genome-wide association studies. Genetic Epidemiology 34:100-5.
Kottgen A, Pattaro C, Bger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, …, Chasman DI, Kao WH, Heid IM, Fox CS. (2010) New loci associated with kidney function and chronic kidney disease. Nature Genetics 42(5):376-84.
Suchindran S, Rivedal D, Guyton JR, Milledge T, Gao X, Rowell J, Ginsburg GS, and McCarthy JJ. (2010) Genome-wide association study of Lp-PLA2 activity in the Framingham Heart Study. PLoS Genetics 6(4):e1000928.
Heard-Costa NL, Zillikens MC, Monda KL, Johansson A, Harris TB, Fu M, Haritunians T, Feitosa MF, …, Gao X, …, Fox CS, North KE (2009) NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGe consortium. PLoS Genet 5(6):e1000539.
Gao X, Martin ER, Liu Y, Vance JM, Scott WK (2009) Genome-wide linkage screen in familiar Parkinson disease identifies novel on chromosomes 3 and 18. American Journal of Human Genetics 84(4):499-504.
Gao X and Martin ER (2009) Using allele sharing distance for detecting human population stratification. Human Heredity 68(3):182-91. PMID: 19521100.
Gao X, Starmer J and Martin ER (2008) A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genetic Epidemiology 32:361-369.
Gao X and Starmer J (2008) AWclust: point-and-click software for non-parametric population structure analysis. BMC Bioinformatics 9:77.
Gao X, Scott WK, Wang G, Mayhew G, Li YJ, Vance JM, Martin ER (2008) Gene-gene interaction between FGF20 and MAOB in Parkinson disease, Annals of Human Genetics 72:157-162.
Gao X, Starmer J. (2007) Human population structure detection via multilocus genotype clustering. BMC Genet. 8:34.