Sun Lab 2017-07-28T12:42:15+00:00

SUN LAB

Research Interests

Role of gut microbiome and vitamin D receptor in intestinal homeostasis and inflammation.

Our studies provide novel insights into vitamin D receptor regulation of gut microbiome. We generated a mouse model with intestinal VDR conditional knockout. We reported that ATG16L1 and Claudin-2 as novel VDR target genes.

Identification and elucidation of the Salmonella effector protein AvrA in host-bacterial interactions.

Our studies are the first to report the Salmonella regulation of the intestinal Wnt/ β-catenin pathway through bacterial effector protein AvrA in acute and chronic infection models.

Establish new experimental models to study infection and colon cancer. 

We reported the first Salmonella-infected colon cancer model. My featured paper also reports a novel humanized mouse model to study the tumor progress in HIV infection

Characterization of intestinal stem cells in inflammation, infection and cancer.

Our lab is the first to report that Salmonella regulation of intestinal stem cells through the Wnt/ β-catenin pathway (Liu, et al., FEBS letter, 2010). This finding also led to our award by the New York State’s Empire State Stem Cell Board to study the enteric bacteria and ISCs in inflammation and cancer. We reported that Sox2 cooperates with inflammation-Mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells (Liu, et al., Cell Stem Cells. 2013). Our lab has developed the first model using intestinal-stem derived organoids to study host-bacterial interactions (Zhang, et al. Phys Reports 2014).

 

Jun Lab Picture At Uic 2015

Lab Highlights

Target Microbiome In Prevention And Treatment Of Human Jin Front Cover

Lab Personnel

Name  Contact

Yongguo Zhang
Research Assistant Professor
Room 710 CSB
Email: yongguo@@uic.edu 
312-996-6010
Lu RongInstructor
Room 710 CSB
Email: ronglu1@@uic.edu 
312-996-6010
Lin ZhijiePhD Student
Room 710 CSB
Email: 33123209@qq.com 
312-996-6010
Jin DapengPhD Student
Room 710 CSB
Email: Dapeng_jin@rush.edu 
312-996-6010
Shang MeiPhD Student
Room 710 CSB
Email: shangmei12345@163.com
312-996-6010

INSTRUCTIONS: In order to add a sidebar anchor:

  1. Duplicate the existing item, listed as a 1/6 text field. (Or create a 1/6 column and add a text field, modify the class so it’s exactly “additionalAnchor”).
  2. Modify the text field inside the 1/6 column. Inside there, modify the HYPERLINK so that it would go to a corresponding section with a “#” in front of it. (Example, we have a “chief” section on the page, then it would make sense to have the hyperlink go to “#chief”)
  3. Then change the hyperlink TEXT to a appropriate label.
  4. IMPORTANT: If not done already, go into that CONTAINER that corresponds to your anchor (i.e. Meet The Chiefs), and add an ID matching the anchor’s HYPERLINK WITHOUT the “#”, i.e. “chief”.
  5. (If using side bar widget box, then there’s a saved copy of a widget box COLUMN, grab it in the column library, it should 1/6 of a length of a column.)

NOTE: Order added to the sidebar is from last to first.