RavinderSerotonin Transporter (SERT) is a well-known primary target for anti-depressant drugs, however, its role in the pathogenesis of various gastro-intestinal disorders is recently emerging. Utilizing a wide array of distinct and complementary approaches, we have extensively characterized the function and expression of the SERT in the native human intestine. In recent years, our work has provided novel insights into the role of protein tyrosine phosphatases, epigenetic mechanisms involving histone deacetylase 2 (HDAC2) and transcriptional mechanisms in the regulation of SERT function and expression. Our studies also demonstrated that SERT is a target of enteric pathogens such as Enteropathogenic E. coli. Utilizing state-of-the-art cellular and molecular approaches, we are currently investigating regulation of SERT expression by growth factors such as TGF-beta 1 with an aim to identify critical mechanisms that upregulate SERT as a novel therapeutic intervention. In addition, we are investigating whether intestine specific SERT variant is differentially regulated in health and disease. These studies are clinically relevant for treating Crohn’s disease and other gut disorders associated with altered serotonin availability in the gut lumen.

Lab Personnel

Name  Contact

Megha Singhal
Post-Doctoral Fellow
Phone: 312-569-7463
Email: [email protected]
Chris  Anoop KumarMD PhD Student
Phone: 312-569-7463
Email: [email protected] 

INSTRUCTIONS: In order to add a sidebar anchor:

  1. Duplicate the existing item, listed as a 1/6 text field. (Or create a 1/6 column and add a text field, modify the class so it’s exactly “additionalAnchor”).
  2. Modify the text field inside the 1/6 column. Inside there, modify the HYPERLINK so that it would go to a corresponding section with a “#” in front of it. (Example, we have a “chief” section on the page, then it would make sense to have the hyperlink go to “#chief”)
  3. Then change the hyperlink TEXT to a appropriate label.
  4. IMPORTANT: If not done already, go into that CONTAINER that corresponds to your anchor (i.e. Meet The Chiefs), and add an ID matching the anchor’s HYPERLINK WITHOUT the “#”, i.e. “chief”.
  5. (If using side bar widget box, then there’s a saved copy of a widget box COLUMN, grab it in the column library, it should 1/6 of a length of a column.)

NOTE: Order added to the sidebar is from last to first.