Endocrinology, Diabetes and Metabolism Recent Grants, Awards, & Publications
Recent Grants
Dr. Brian Layden, MD, PhD
“A Novel Relationship Between the Gut Microbiota and Pancreatic Beta Cells contributes to Gestational Glucose Homeostasis” (Veterans Affairs Merit Review Program): 04/01/2017-03/31/2021.
“The Function and Regulation of the Novel Pregnancy-Specific Hexokinase HKDC1” (NIH R01): 03/13/2017 – 07/31/2020
“Diabetes Research and Training Center” (University of Chicago): 09/01/2016 – 01/31/2018
“Gut microbiota, short chain fatty acids, and adiposity across the epidemiologic transition” (Loyola NIH R01): 09/01/2016 – 08/31/2021
Dr. Robert Sargis, PhD, MD
“Mechanisms and Potentiators of Arsenic-Induced Metabolic Dysfunction” (American Diabetes Association): 01/01/2017 – 12/31/2019
Dr. Terry Unterman, MD
“Regulation of Hepatic Gene Expression and Metabolism by FoxO Proteins” (Veterans Affairs Merit Review Program): 04/01/2017-03/31/2021
Recent Awards Heading link
Dr. Terry Unterman, MD
“Regulatory Networks in Diabetes Mellitus” (VA Career Development Enhancement Award): 01/01/2018 – 6/30/2018
Recent Publications Heading link
Dr. Brian Layden, PhD, MD
Dugas LR, Fuller M, Gilbert J, Layden BT. The obese gut microbiome across the epidemiologic transition. Emerg Themes Epidemiol. 2016 Jan 11;13:2.
Priyadarshini M, Wicksteed B, Schiltz GE, Gilchrist A, Layden BT. SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets? Trends Endocrinol Metab. 2016 Sep;27(9):653-64.
Dickson LM, Gandhi S, Layden BT, Cohen RN, Wicksteed B. Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R79-88.
Villa SR, Priyadarshini M, Fuller MH, Bhardwaj T, Brodsky MR, Angueira AR, Mosser RE, Carboneau BA, Tersey SA, Mancebo H, Gilchrist A, Mirmira RG, Gannon M, Layden BT. Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival. Sci Rep. 2016 Jun 21;6:28159.
Toft DJ, Fuller M, Schipma M, Chen F, Cryns VL, Layden BT. αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance. Genom Data. 2016 May 13;9:10-7.
Levine JA, Kaihara KA, Layden BT, Wicksteed B. Long-term activation of PKA in β-cells provides sustained improvement to glucose control, insulin sensitivity and body weight. Islets. 2016 Sep 2;8(5):125-34.
Dugas LR, Chorell E, Plange-Rhule J, Lambert EV, Cao G, Cooper RS, Layden BT, Scholten D, Olsson T, Luke A, Goedecke JH. Obesity-related metabolite profiles of black women spanning the epidemiologic transition. Metabolomics. 2016 Mar;12(3). pii: 45.
Ludvik AE, Pusec CM, Priyadarshini M, Angueira AR, Guo C, Lo A, Hershenhouse KS, Yang GY, Ding X, Reddy TE, Lowe WL Jr, Layden BT. HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use. Endocrinology. 2016 Sep;157(9):3452-61.
Illuri VD, Layden BT, Aleppo G. Extreme Insulin Resistance in Critically Ill Patient With Sepsis. Clin Diabetes. 2016 Jul;34(3):158-60.
Fuller M, Li X, Fisch R, Bughara M, Wicksteed B, Kovatcheva-Datchary P, Layden BT. FFA2 Contribution to Gestational Glucose Tolerance Is Not Disrupted by Antibiotics. PLoS One. 2016 Dec 13;11(12):e0167837.
Mariani HS, Layden BT, Aleppo G. Continuous Glucose Monitoring: A Perspective on Its Past, Present, and Future Applications for Diabetes Management. Clin Diabetes. 2017 Jan;35(1):60-65.
Layden BT, Wicksteed B, Mauvais-Jarvis F. Incretin-Based Therapies: Revisiting Their Mode of Action. Endocrinology. 2017 Jun 1;158(6):1560-1563.
Dr. Rhonda Kineman, PhD
Kineman RD, Majumdar N, Subbaiah PV, Cordoba-Chacon J. Hepatic PPARg is not essential for the rapid development of steatosis following loss of hepatic GH signaling, in adult male mice. Endocrinology. 2016. 157(5):1728-35.
Liu Z, Cordoba-Chacon J, Kineman RD, Cronstein BN, Muzumdar R, Gong Z, Werner H, Yakar S. GH hormone control of lipid metabolism. Diabetes 65(12):3598-3609, 2016.
Ibáñez-Costa A, López-Sánchez LM, Gahete MD, Rivero-Cortés E, Vázquez-Borrego MC, Gálvez MA, de la Riva A, Venegas-Moreno E, Jiménez-Reina L, Moreno-Carazo A, Tinahones FJ, Maraver-Selfa S, 6. Japón MA, García-Arnés JA, Soto-Moreno A, Webb SM, Kineman RD, Culler MD, Castaño JP, Luque RM. BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas. Sci Rep. 2017 Feb 9;7:42002.
Wolf-Greenstein A, Majumdar N, Yang P, Subbaiah PV, Kineman RD, Cordoba-Chacon J. Hepatocyte-specific, PPAR -regulated mechanisms to promote steatosis in adult mice. Accepted with minor revisions Journal of Endocrinology 232(1):107-121, 2017.
Dr. Subhash Kukreja, MD
Gupta Y, Marwaha RK, Kukreja S, Bhadra K, Narang A, Mani K, Mithal A, Tandon N. Relationship Between BMD and Prevalent Vertebral Fractures in Indian Women Older Than 50 Yr. J Clin Densitom. 2016 Apr-Jun;19(2):141-5.
Dr. Dan Mihailescu, MD
Martyn-Nemeth P, Farabi S, Mihailescu D, Nemeth J, Quinn L. Fear of Hypoglycemia in Adults with Type 1 Diabetes: Impact of Therapeutic Advances and Strategies for Prevention – A Review. Journ of Diab Compl, 2016, Jan 30:167-177.
Dr. Robert Sargis, MD, PhD
Genere N, Sargis RM, Masi CM, Nathan AG, Quinn MT, Huang ES, Laiteerapong N. Physician perspectives on de-intensifying diabetes medications. Medicine (Baltimore). 2016 Nov;95(46):e5388.
Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R, Vandenberg LN, Vom Saal F. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 2017 Mar;68:3-33.
Mimoto MS, Nadal A, Sargis RM. Polluted Pathways: Mechanisms of Metabolic Disruption by Endocrine Disrupting Chemicals. Curr Environ Health Rep. 2017 Jun;4(2):208-222.
Dr. Papasani Subbaiah, PhD
Subbaiah PV, Dammanahalli, K, Yang,P, Bi, J, O’Donnell, JM. Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. Biochim. Biophys. Acta 1861: 723-729, 2016.
Sugasini D, Yang P, Ng D, Khetarpal S, Vitali C, Rader D, and Subbaiah PV. Potential role of hepatic lipase in the accrual of docosahexaenoic acid (DHA) in the brain. The FASEB Journal, 31(Supplement 1),781.4, 2017
Dr. Terry Unterman, MD
Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC. Coupling Between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 290:30551-61, 2016.
Chung S, Lee TJ, Reader BF, Kim JY, Lee YG, Park GY, Karpurapu M, Ballinger MN, Qian F, Rusu L, Chung HY, Unterman TG, Croce CM, Christman JW. FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget. 2016 Mar 17.
Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. J Oral Biol (Northborough). 2016;3(1).
Scarlett, JM, Rojas, JM, Matsen, ME, Kaiyala, KJ, Stefanovski, D, Bergman, RN, Nguyen, HT, Dorfman, MD, Lantier, L, Wasserman, DH, Mirzadeh, L, Unterman, TG, Morton, GJ, Schwartz, MW. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.Nature Med 22:800-6, 2016.
Zhang, W., Bu, S.Y., Mashek, M.T., O-Sullivan, I., Sibai, Z., Khan, S.A., Ilkayeva, O., Newgard, C.B., Mashek, D.G., Unterman, T.G.Integrated Regulation of Hepatic Glucose and Lipid Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell Reports, 15:349-359, 2016.
Mahmoud, A.B., Szczurek, M.R., Blackburn, B.K., Mey, J.T., Chen, Z., Robinson, A.T., Bian, J.T., Unterman, T.G., Minshall, R.D., Brown, M.D., Kirwan, J.P., Phillips, S.A., Haus, J.M. Hyperinsulinemia Augments Endothelin-1 Protein Expression and Impairs Vasodilation of Human Skeletal Muscle Arterioles. Physiol Rep. 2016 Aug;4(16). pii: e12895.
Ilievski, V., Kinchen, J.M., Prabhu, R., Rim, F., Leoni, L., Unterman, T.G., Watanabe, K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. J Oral Biol (Northborough). 2016;3(1).
Valitsky, M., Hoffman, A., Unterman, T., Bar-Tana, J.Insulin Sensitizer Prevents and Ameliorates Experimental Type-1 Diabetes. Am J Physiol Endocrinol Metab. 2017 Mar 7:ajpendo.00329.2016.