Cardiology Research
Overview
At the University of Illinois Chicago’s Center for Regenerative Medicine in Cardiology, our mission is to explore the developmental and functional properties of cardiac muscle through the use of embryonic and adult stem cells. We will extend our basic science results to preclinical studies in animal models of cardiovascular disease with defined therapeutic outcomes. Our goal is to develop clinical trials that translate our preclinical research into safe and effective ways of treating cardiovascular disease in our patients.
Basic Research
• Tissue graft cardiac cell replacement
• Stem cell homing and engraftment
• Proliferation and differentiation of cardiac stem cells
• Intercellular communication between embryonic-derived cardiac cells
Cardiology Recent Grants, Awards, & Publications Heading link
- POSITIONAL CLONING AND CANDIDATE GENE APPROACH TO FAMILIAL ATRIAL FIBRILATION
R01HL092217; (PI Darbar) - TOWARD A MECHANISM-BASED APPROACH TO TREATING ATRIAL FIBRILLATION
R01HL124935; MPI (Co-PI Darbar) - THE ROLE OF MITOCHONDRIA IN EMBRYONIC STEM CELLS
R01GM094220; (PI Rehman) - IPSC DERIVED ENDOTHELIAL PROGENITOR CELL TREATMENT OF LUNG VASCULAR INJURY
R01HL090152; MPI (Co-PI Rehman) - ENDOTHELIA REGENERATION FOLLOWING LUNG VASCULAR INJURY
R01HL118068; MPI grant (Co-PI Rehman) - PPP1R12C CONTRIBUTES TO MYOSIN LIGHT CHAIN DE-PHOSPHORYLATION AND ATRIAL HYPOCONTRACTILITY IN ATRIAL FIBRILLATION
K08HL130587; (PI McCauley) - MYOFILAMENT SIGNALING AND CARDIAC DISORDERS
R01HL128468; MPI (Co-PI Wolska) - DECIPHERING THE GENETIC MECHANISMS OF ATRIAL FIBRILLATION
R01HL138737; (PI Darbar)