Jaehyung (Gus) Cho, Ph.D. (Assistant Professor, Anesthesiology & Pharmacology) studies the molecular mechanisms of the platelet-leukocyte-endothelium interactions at the site of vascular injury. These studies are being performed using pharmacologic and genetic approaches in real-time fluorescence microscopy in vitro and in vivo. A better understanding of the regulatory mechanisms of heterotypic cell-cell interactions could lead to the development of effective therapeutics for the prevention in vascular diseases. Dr. Cho is an expert on in vivo intravital microscopy. His work demonstrated that extracellular protein disulfide isomerase (PDI), a prototypic thiol isomerase, plays a critical role in platelet thrombus formation and fibrin generation at the site of arteriolar injury in living mice. Ongoing research has shown that neutrophil surface PDI is required for integrin-mediated neutrophil recruitment during vascular inflammation. Currently, his group is working on the role of thiol isomerases and protein kinases in regulating the heterotypic cell-cell interactions during thrombus formation and vascular inflammation using state-of-the-art intravital microscope system in living mice (3-5).