Carcinogenesis & Chemoprevention Research Program


Carcinogenesis and Chemoprevention Research Program
Leader : Peter Gann, MD, ScD


The scientific focus of the Carcinogenesis and Chemoprevention Program (CCP) is on mechanisms of carcinogenesis, from initiation through promotion and proliferation, and chemoprevention. Emphasis is on hormone dependent cancers such as breast and prostate, as well as colon, liver and oral cancers. Research conducted by program members is aimed at identifying the critical cellular and molecular targets involved in chemically induced carcinogenesis, understanding the biological basis for inherited susceptibility to cancer, and developing and applying biomarkers as intermediate endpoints in Phase II chemoprevention trials. There is a pronounced interest in the role of nutrition and nutritionally-derived compounds in early cancer development.

Our program is organized around three scientific themes:

1) Chemoprevention

2) Biomarker development

3) Hormonal carcinogenesis


Most research within the program is multidisciplinary, and members have core expertise in a variety of fields, including chemical toxicology, hormonal carcinogenesis, cell biology, pharmacology, biochemistry, molecular biology, biochemistry, physiology, mass spectrometry, analytical chemistry, synthetic organic chemistry and pathology.

This program is distinguished by a scope of work that ranges from basic science to population studies and clinical trials. Members frequently collaborate with the University of Illinois Cancer Center investigators in other programs, including clinicians, epidemiologists, behavioral scientists, and bioengineers.