Oscar Colamonici, MD
College of Medicine
Cancer Research/Clinical Interest
Characterization of mammalian components of the Drosophila dREAM (drosophila RB, E2F and Myb) complex, with an emphasis on the components of the MCC/LINC complex Mip130/LIN-9, Mip120/LIN-54 and Mip40/LIN-37. Mammalian MCC/LINC functions as a repressor during G1, and as an activator in conjunction with B-Myb during S-phase. In late G1/S, the complex interacts with B-Myb and positively regulates the transcription of S and G2/M genes such as cyclin A, cyclin B and CDK1. Importantly, one of the components of the complex, Mip130/LIN-9, also participates in the regulation of the Arf-MDM2-p53 pathway. Thus, the MCC/LINC is a critical element in the regulation of the cell cycle progression and senescence in normal, and potentially in tumor cells. One of our objectives is to determine if regulation of MCC/LINC by siRNA or drugs could lead to cell cycle arrest or senescence in tumor cells.
Office: University of Illinois at Chicago
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