.Dr. Deborah Little is an Associate Professor of Neurology andRehabilitation, Anatomy and Cell Biology, and Ophthalmology and Visual Sciences; a Research Associate Professor of Psychology, a member of the Center for Cognitive Medicine and the Director of MRI Research in the Department of Neurology at the University of Illinois College of Medicine at Chicago.
Dr. Little completed both her Masters (1999) and Doctorate (2001) at Brandeis University in Waltham, Massachusetts.Her doctoral work focused on defining cognitive changes that occur as humans age. She then completed a 3-year post-doctoral fellowship in advanced MRI imaging in the Center for MR Research at the University of Illinois Medical Center.
Dr. Little’s research focuses on elucidating the neural structures and pathways that mediate adaptation to new environmental demands. She has ongoing projects in normal aging and also in patients with a history of traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), Parkinson’s Disease, schizophrenia, and bipolar disorder. Her work primarily relies upon advanced MR Imaging but also utilizes a variety of other methods including EEG, eye movements, and assessments of behavior. Dr. Little's research is supported by the College of Medicine at the University of Illinois at Chicago and by grants from the National Institute of Mental Health, National Institute on Aging, Department of Defense, and the CINN Foundation.
Little DM, Kraus MF, Joseph J, Geary EK, Susmaras T, Zhou XJ,
Pliskin N, Gorelick PB. Thalamic integrity underlies executive dysfunction:
Evidence from Traumatic Brain Injury. Neurology (in press).
Little DM, Kraus MF, Jiam C, Moynihan M, Siroko M, Schulze E, Geary
EK. Imaging hypoxic-ischemic brain injury. NeuroRehabilitation (In Press).
Silverstein SM, All SD, Kasi R, Berten S, Essex B, Lathrop K, Little
DM. Increased fusiform area activation in schizophrenia during processing of
spatial frequency-degraded faces, as revealed by fMRI. Psychological
Medicine (In Press)
Benzinger TLS, Brody D, Cardin S, Curley KC, Mintun MA, Mun SK, Wong
KH, Wrathall JR, Armstrong RC, Bayly PV, Bentley TB, Chavko M, Corbetta M,
Culver JP, DeWitt DS, Faden AI, Fiskum G, Fitzpatrick SM, Gennarelli T,
Ghajar J, Gullapalli RP, Hovda D, Jost G, Kharasch ED, Kharasch K, Kochanek
P, Lammle M, Leggieri Jr MJ, Latour LL, Little DM, Mac Donald CL, Macedonia
C, Marcus D, McCabe JT, McCarron RM, Moore D, Mukherjee P, Povlishock J,
Pancrazio J, Petersen S, Peskind ER, Pierce KJ, Pineda JA, Raskind M, Riedel
C, Ritzel D, Shimony JS, Boyd Smith A, Simth DH, Smirniotopoulos J,
Sheng-Kwei Song V, Sterkel BB, Svetlov S, VandeVord PJ, Young AW, Zipfel G.
Blast-related Brain Injury: Imaging for Clinical and Research Applications
Report of the 2008 St. Louis Workshop. Journal of Neurotrauma (In press,
doi: 10.1089/neu.2009-0885).
Szlyk JP, Little DM. Cortical networks subserving word recognition
in age-related macular degeneration. Investigative Ophthalmology and Visual
Sciences 2009; 50: 4487-4495 (PMID: 19387076).
Silverstein SM, Berten S, Essex B, Kovacs I, Susmaras T, Little DM.
An fMRI examination of visual integration in Schizophrenia. Journal of
Integrative Neuroscience 2009; 8(2): 175-202.
Maki PM, Cohen M, Weber K, Little DM, Fornelli D, Perschler P, Gould
F, Martin E. Deficits in verbal memory and hippocampal function in
HIV-positive women. Neurology 2009; 7: 1661-1668.
Vaillancourt DE, Spraker MB, Prodoehl J, Abraham I, Corcos DM,
Comella CL, Little DM. High-resolution diffusion tensor imaging in the
caudal portion of the substantia nigra of de novo Parkinson's disease.
Neurology 2009; 72: 1378-1384.