Sandeep Jain, MD

Sandeep Jain, MD

Associate Professor of Ophthalmology
Cornea Service
Director, Corneal Neurobiology Laboratory
Director, Dry Eye Service

Editorial Board Member, Investigative Ophthalmology & Visual Sciences; Ocular Surface

Mailing Address:
Illinois Eye and Ear Infirmary
1855 W. Taylor Street, M/C 648
Chicago, IL 60612

Sees patients at:
The Illinois Eye and Ear Infirmary
1855 W. Taylor Street
Cornea Service
Suite 3.164
Clinic Phone: (312) 996-8937

request and appointment Comprehensive Ophthalmology Faculty
Suite 1.059
COFP Phone: (312) 355-5220

Dry Eye Clinical Trial Phone Line: 312-918-0900


Dr. Jain’s research focuses on the molecular and cellular aspects of corneal nerve regeneration, which may lead to new therapies for blinding corneal diseases. His research is funded by the National Eye Institute K08 and R01 awards. Currently, he is initiating clinical trials on treatment for dry eye. He has been named one of America’s Best Doctors since 2007 and has received the American Academy of Ophthalmology’s Achievement Award. Dr. Jain joined the Illinois Eye and Ear Infirmary in 2006. He is board certified in ophthalmology.


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MD—University of Delhi, India
Research Fellowship in Cornea and External Diseases—Wilmer Eye Institute, Johns Hopkins University, Baltimore
Residency—Harkness Eye Institute, Columbia University, New York
Clinical Fellowship in Cornea—Massachusetts Eye and Ear Infirmary, Harvard Medical School
Scholars for Teaching Excellence Faculty Fellowship, University of Illinois at Chicago

Selected Honors and Awards

Faculty of the Year Award, College of Medicine, University of Illinois at Chicago, 2015
Research to Prevent Blindness Physician Scientist Award, 2014
Chicago Super Doctors, 2013
Best Doctors in America, 2007 - 2014
American Academy of Ophthalmology Achievement Award, 2002

Recent Publications

Shaheen BS, Bakir M, Jain S. Corneal nerves in health and disease. Surv Ophthalmol. 2014 Jan 22. pii: S0039-6257(13)00208-7. doi: 10.1016/j.survophthal.2013.09.002. [Epub ahead of print] PubMed PMID: 24461367.

Tibrewal S, Sarkar J, Jassim SH, Gandhi S, Sonawane S, Chaudhary S, Byun YS, Ivanir Y, Hallak J, Horner JH, Newcomb M, Jain S. Tear fluid extracellular DNA: diagnostic and therapeutic implications in dry eye disease. Invest Ophthalmol Vis Sci. 2013 Dec 11;54(13):8051-61. doi: 10.1167/iovs.13-12844. PubMed PMID: 24255046; PubMed Central PMCID: PMC3860379.

Ogawa Y, Kim SK, Dana R, Clayton J, Jain S, Rosenblatt MI, Perez VL, Shikari H, Riemens A, Tsubota K. International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I). Sci Rep. 2013 Dec 5;3:3419. doi: 10.1038/srep03419. PubMed PMID: 24305504; PubMed Central PMCID: PMC3851919.

Sarkar J, Chaudhary S, Jassim SH, Ozturk O, Chamon W, Ganesh B, Tibrewal S, Gandhi S, Byun YS, Hallak J, Mahmud DL, Mahmud N, Rondelli D, Jain S. CD11b+GR1+  myeloid cells secrete NGF and promote trigeminal ganglion neurite growth: implications for corneal nerve regeneration. Invest Ophthalmol Vis Sci. 2013 Sep  3;54(9):5920-36. doi: 10.1167/iovs.13-12237. PubMed PMID: 23942970; PubMed Central PMCID: PMC3762328.

Tu EY, Jain S. Topical linezolid 0.2% for the treatment of vancomycin-resistant or vancomycin-intolerant gram-positive bacterial keratitis.  Am J Ophthalmol. 2013 Jun;155(6):1095-1098.e1. doi: 10.1016/j.ajo.2013.01.010. Epub 2013 Feb 26. PubMed PMID: 23453280.

Hallak JA, Jassim S, Khanolkar V, Jain S. Symptom burden of patients with dry  eye disease: a four domain analysis. PLoS One. 2013 Dec 13;8(12):e82805. doi: 10.1371/journal.pone.0082805. eCollection 2013. PubMed PMID: 24349365; PubMed Central PMCID: PMC3862676.

Sonawane S, Khanolkar V, Namavari A, Chaudhary S, Gandhi S, Tibrewal S, Jassim SH, Shaheen B, Hallak J, Horner JH, Newcomb M, Sarkar J, Jain S. Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease. Invest Ophthalmol Vis Sci. 2012 Dec 17;53(13):8253-63. doi: 10.1167/iovs.12-10430. PubMed PMID: 23169882; PubMed Central PMCID: PMC3525138.

Chaudhary S, Namavari A, Yco L, Chang JH, Sonawane S, Khanolkar V, Sarkar J, Jain S. Neurotrophins and nerve regeneration-associated genes are expressed in the cornea after lamellar flap surgery. Cornea. 2012 Dec;31(12):1460-7. doi: 10.1097/ICO.0b013e318247b60e. PubMed PMID: 22673847; PubMed Central PMCID: PMC3612527.

Namavari A, Chaudhary S, Ozturk O, Chang JH, Yco L, Sonawane S, Katam N, Khanolkar V, Hallak J, Sarkar J, Jain S. Semaphorin 7a links nerve regeneration and inflammation in the cornea. Invest Ophthalmol Vis Sci. 2012 Jul 9;53(8):4575-85. doi: 10.1167/iovs.12-9760. PubMed PMID: 22700709; PubMed Central PMCID: PMC3394693.

Jain S, De la Cruz J, Kang E, Kojima T, Chang JH, Kim JY. Expression of phosphorylated heat shock protein 27 during corneal epithelial wound healing. Cornea. 2012 Jul;31(7):820-7. doi: 10.1097/ICO.0b013e31823f7685. PubMed PMID: 22262220; PubMed Central PMCID: PMC3649853.

Sarkar J, Chaudhary S, Namavari A, Ozturk O, Chang JH, Yco L, Sonawane S, Khanolkar V, Hallak J, Jain S. Corneal neurotoxicity due to topical benzalkonium  chloride. Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4):1792-802. doi: 10.1167/iovs.11-8775. PubMed PMID: 22410563.

Namavari A, Chaudhary S, Chang JH, Yco L, Sonawane S, Khanolkar V, Yue BY, Sarkar J, Jain S. Cyclosporine immunomodulation retards regeneration of surgically transected corneal nerves. Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):732-40. doi: 10.1167/iovs.11-8445. Print 2012 Feb. PubMed PMID: 22205605; PubMed Central PMCID: PMC3317418.

Chang JH, Garg NK, Lunde E, Han KY, Jain S, Azar DT. Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol. 2012 Sep;57(5):415-29. doi: 10.1016/j.survophthal.2012.01.007. Review. PubMed PMID: 22898649; PubMed Central PMCID: PMC3709023.

Han KY, Fahd DC, Tshionyi M, Allemann N, Jain S, Chang JH, Azar DT. MT1-MMP modulates bFGF-induced VEGF-A expression in corneal fibroblasts. Protein Pept Lett. 2012 Dec;19(12):1334-9. PubMed PMID: 22670674; PubMed Central PMCID: PMC3653774.

Han KY, Azar DT, Sabri A, Lee H, Jain S, Lee BS, Chang JH. Characterization of the interaction between endostatin short peptide and VEGF receptor 3. Protein Pept Lett. 2012 Sep;19(9):969-74. PubMed PMID: 22512651; PubMed Central PMCID: PMC3646568.

Tshionyi M, Shay E, Lunde E, Lin A, Han KY, Jain S, Chang JH, Azar DT. Hemangiogenesis and lymphangiogenesis in corneal pathology. Cornea. 2012 Jan;31(1):74-80. doi: 10.1097/ICO.0b013e31821dd986. PubMed PMID: 22030600; PubMed Central PMCID: PMC3710690.