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Hematology Clinical Trials

 

Study Name:

A Phase I Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation for Advanced Hematologic Malignancies.

 

 

         

Purpose:

This is a phase I study using Intensity Modulated Total Marrow Irradiation (IM-TMI) in addition to a chemotherapy regimen in preparation for an allogeneic stem cell transplant for advanced hematologic malignancies such as acute myeloid or lymphoblastic leukemia, high grade non Hodgkin's or Hodgkin's lymphoma, chronic myelogenous leukemia, and plasma cell leukemia.

Study Type: Treatment

Protocol: UIC 2009-0251 IM-TMI

 

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Study Name:

A Phase-3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Compare Efficacy and Safety of Pomalidomide in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis and Red Blood Cell Transfusion Dependence.

         

Purpose:

 The objective of this study is to determine whether pomalidomide is safe and effective in reversing RBC-transfusion-dependence in persons with myeloproliferative neoplasm (MPN)-associated myelofibrosis

Study Type: Treatment

Protocol: UIC 2011-0434 Celgene CC-4047

 

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Study Name:

Single Arm Salvage Therapy With Pegylated Interferon Alfa-2a for Patients With High Risk Polycythemia Vera or High Risk Essential Thrombocythemia Who Are Either Hydroxyurea Resistant or Intolerant or Have Had Abdominal Vein Thrombosis.

         

Purpose:

 The purpose of this study is to look at the effectiveness of giving patients who have been diagnosed with ET and PV a study drug regimen using Aspirin and PEGASYS (also known as Pegylated interferon alfa-2a, instead of the standard treatment drug called Hydroxyurea (or hydroxycarbamide or Hydroxyurea), for whom this drug may not be suitable.

Study Type: Treatment

Protocol: UIC 2011-0089 MPD-RC 111

 

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Study Name:

Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea Therapy in the Treatment of High Risk Polycythemia Vera (PV) and High Risk Essential Thrombocythemia (ET).

         

Purpose:

 The purpose of this study is to look at the effectiveness of giving participants who have been diagnosed with ET or PV one of two different study regimens over time.

Study Type: Treatment

Protocol: UIC 2011-0234 MPD-RC 112

 

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Study Name:

A Multicenter, Open Label Phase I/II Study of CEP-701 (Lestaurtinib) in Adults with Myelofibrosis.

 

 

 

         

Purpose:

The purpose of the biomarker study is to understand the causes of MPD and to develop improved methods for the diagnosis and treatment of these diseases, while the main study is trying to find out how well CEP-701 (Lestaurtinib) will work in treating the myeloproliferative disease.

Study Type: Treatment

Protocol: UIC 2008-0578 MPD-RC 104

 

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Study Name:

Molecular Biology of Familial Myeloproliferative Disorders.

 

 

 

         

Purpose:

Understanding which genes are responsible for causing MPDs can help develop ways to identify people who may be at risk for developing an MPD, allow for the development of better treatments, possibly a cure, or even prevent the development of MPDs.

Study Type: Observational

Protocol: UIC 2007-0538 MPD-RC 105

 

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Study Name:

 Research Tissue Bank.

 

         

Purpose:

The goals of this research study are to understand the causes of MPDs, how to diagnose them more easily and how to treat them better.

Study Type: Observational

Protocol: UIC 2007-0260 MPD-RC 106

 

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Study Name:

Correlative Biomarker Study for MPD-RC Treatment Studies in the Philadelphia Chromosome Negative MPD.

         

Purpose:

The investigators are attempting to better understand the causes of MPD and to develop improved methods for the diagnosis and treatment of these diseases.

Study Type: Observational

Protocol: UIC 2007-0143 MPD-RC 107

 

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Study Name:

Study of Fludarabine Based Conditioning for Allogeneic Stem Cell Tranplantation for Myelofibrosis.

         

Purpose:

The purpose of this study is to observe if reduced intensity transplants can be used to allow engraftment or "take" of the donor's bone marrow.

Study Type: Treatment

Protocol: UIC 2007-0065 MPD-RC 101

 

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Study Name:

 Contribution of a Blood Sample to the National Marow Donor Program's Research Sample Repository.

         

Purpose:

The information will be used to help determine how well transplant recipients recover from their transplant, how recovery after a transplant can be improved, how access to transplant for different groups of patients can be improved and how well donors recover from collection procedures.

Study Type: Observational

Protocol: UIC 2002-0797 NMDP

 

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Study Name:

 A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications

         

Purpose:

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

Study Type: Observational

Protocol: UIC  NMDP 10-CBA

 

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Study Name:

The National Marrow Donor Program (NMDP) and Center for International Blood and Marrow Transplant Research (CIBMTR): Research Database for Hematopoietic Stem Cell Transplantation and Marrow Toxic Injuries

         

Purpose:

To learn more about what makes stem cell transplants work well, such as determining the following: how well recipients recover from their transplant, how recovery after a transplant can be improved, how access to transplant for different groups of patients can be improved, and how well donors recover from the collection procedures.

Study Type: Observational

Protocol: UIC 2002-0795 NMDP CIBMTR

 

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Study Name:

Phase I/II Study of Allogeneic Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

         

Purpose:

The purpose of this trial is to use the allogeneic stem cell transplantation system to treat clinically aggressive Sickle Cell Disease.

 

Study Type: Treatment

Protocol: UIC 2011-0096 Santosh SCD

 

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