March 19, 2012

university of Illinois CANCER CENTER


News Briefs

Cancer Center and member news
Ozer named Cancer Center Director
The Cancer Center is delighted to announce that Howard Ozer, MD, PhD, has been named Director of the Cancer Center, pending Board of Trustees approval. Ozer had served as Interim Director since January, 2011. See full announcement here.

Andrei Gartel, associate professor of biochemistry and molecular genetics and medicine, is quoted in a news story about his recent research on a potential way to trick cancer cells into committing suicide in the online news site daily Rx. Click here to see the full article.


The Chicago Tribune published a Voice of the People letter by Dr. Pier C. Giulianotti, chief of minimally invasive, general and robotic surgery at the University of Illinois Hospital, in response to a February 26 article on robotic surgery. Click here to see letter.



Cancer Center Member, Gail Prins, PhD, was profiled in UIC News this month. Click here to view the article.

More than 30 volunteers had their heads shaved to raise money for pediatric cancer research. CBS 2 News reported "live" from the St. Baldrick's Foundation head shaving event at the University of Illinois Hospital. FM News 101.1, Chicago Sun-Times, Local News Service, Medill News and the Columbia Chronicle also covered the event. To watch the segments, click here.
New members

The Cancer Center welcomes these new members:

Meiling Lu, PhD
is a research faculty member in Biopharmaceutical Sciences in the College of Pharmacy and joins the Cancer Targets, Therapeutics and Imaging Program.

Rajyasree Emmadi, MD
is an assistant professor in Pathology in the College of Medicine and joins the Cancer Cell Signaling Program

Sekhar Reddy, PhD
is a professor in Pediatrics in the College of Medicine and
joins the Cancer Cell Signaling Program


Zhenyuan Song, PhD
is an assistant professor in Applied Health Science in the College of Kinesiology and Nutrition and joins the Cancer Targets, Therapeutics and Imaging Program.

Spotlight: Cancer Research Forum

Cancer Research Forum demonstrates our leadership in cancer research

The success of the recent Cancer Research Forum attests to the outstanding cancer research that is being conducted at the University of Illinois. The 120 posters (above) presented at this first-ever Forum showcased the high impact and wide scope of the research of our associates, students, and fellows at Chicago, Urbana-Champaign, and Rockford. "The sight of a bustling room full of cancer researchers interacting and sharing ideas, was a physical manifestation of what the Cancer Center is all about," said Howard Ozer, PhD, Director of the Cancer Center.

More than 250 people attended the event at UIC's Student Center West, which featured a keynote address by Benita Katzenellenbogen, PhD. The event also included presentations by the 2010 Pilot Grant Awardees and an informal panel for students and clinicians. During an awards ceremony, the following six students and fellows received prizes: Carolina Soto, Elizabeth Parkinson, Yu Zheng, Dana Felice, PhD, Dragana Kopanja, PhD, and Michael Walsh, PhD. Go to Forum website for full details.

"We are delighted with the outcome of the Forum, and we will build on its momentum as we continue to enhance our membership and facilitate collaboration among our members on all campuses," said Ozer.

Cancer Community at Urbana-Champaign

The University of Illinois at Urbana-Champaign is home to a large and thriving group of investigators engaging in cancer-related research called the Cancer Community at Illinois. The Research Forum introduced many of them to the Cancer Center and communications with this group becoming more active and engaged. Click here to go to their website.


2012 Cancer Community @ Illinois Symposium

The Urbana-Champaign cancer group has planned a Symposium featuring many notable speakers including: Mark A. Kay, M.D., Ph.D., Liangfang Zhang, Ph.D., Daniel G. Anderson, Ph.D., Daniel A. Heller, Ph.D., David M. Weinstock, M.D., Jonathan D. Licht, M.D., Jose M. Silva, Ph.D., Richard B. Jones, Ph.D., and John F. McDonald, Ph.D.

The Symposium will be held April 5th through 6th and will also feature lectures from UIUC faculty, student oral and poster presentations, and a panel-style discussion. To register, go to the website. Deadline for registration is March 23.

Town Hall proceedings
Cancer Center Director Howard Ozer, MD, PhD, presided over a Town Hall meeting on March 8. He began by recognizing these members: Pradip Raychaudhuri, PhD on being named University Scholar; Gail Prins, PhD on being named OVCR (Office of the Vice Chancellor for Research) Researcher of the Year; as well as the 15 members who received OVCR Area of Excellence awards.

Ozer then described the Cancer Center’s work toward NCI designation and the specific requirements to achieve it. These included the six essential characteristics of a cancer center: Center Director, Institutional Commitment, Facilities, Cancer Focus, Transdisciplinary Collaboration, and Organizational Capabilities. He pointed out the Cancer Center’s many important distinguishing characteristics, including our work on both urban and rural health disparities, our statewide footprint spanning four University of Illinois campuses, and the development of clinical trials specifically targeting treatment of underrepresented minorities in Chicago neighborhoods and throughout the state.

The benefit of the Cancer Center’s linkage with Urbana-Champaign (UIUC) became clear as Ozer enumerated the campus’s relevant characteristics and resources:  $100 million in NIH funding; $500 million total funding; 5th ranked Engineering College; 1st ranked Animal Sciences Program; $7 million (total costs) in NCI Funding; $20 million in cancer-related funding; Beckman Institute for Advanced Science and Technology; Center for the Physics of the Living Cell (NSF); and the Midwest Cancer Nanotechnology Training Center (NCI), among others. Ozer noted how seamless the integration of the Cancer Center and UIUC was, and emphasized that Urbana-Champaign is an integral part of the CCSG proposal. The Cancer Center’s overall goal is to become integrated into the overall cancer-related efforts on the Urbana-Champaign campus.

Major accomplishments of the Cancer Center include: development of Behavioral Research Methods Shared Resource; recruitment of a joint of a drug discovery investigator with the COP; a new Pilot grant program; growing support for multi-investigator grants including the recent Liver PPG; and plans to submit an ACS Institutional Research Grant. Ozer ended with the organizational achievements of the Cancer Center:  reorganization of Laboratory Shared Resources with academic directors appointed; reactivation of its Internal Advisory Board and enlarging its scope to system-wide; establishment of Data and Safety Monitoring Plan and Data and Safety Monitoring Committee; and the complete revision of the Clinical Trials Office structure and personnel.

Attendees were presented throughout with the clear progression of steps taken to prepare for the Cancer Center Support Grant application. In the end, it was announced that the Cancer Center was “on schedule” in the application process, and that the very the important step of writing the grant was ready to begin.












In this issue

  Town Hall Report

upcoming events


Recent Publications

  new funding opportunities

Cancer Center Pilot Grant

deadlines extended:
LOI's now due April 2, 2012
Applications due May 1, 2012

Shared Resource Subsidy Program extended to June 20, 2012. This valuable benefit of your Cancer Center membership subsidizes your Shared Resource usage fees at the rate of 30%.

Click here for details.

University of Illinois
Cancer Center
Junior Cancer Investigator
Pilot Grant Program

Full application due March 21, 2012
Deadline for LOI (required) is now over

Frontiers in Cancer Research
Wednesday, April 4 2:00-5:30pm
MBRB, 900 S. Ashland Herman Auditorium

Invited speakers:
Elaine Mardis, PhD
Louis M. Staudt, MD, PhD
William Sellers, MD
Jiri Bartek, MD, PhD

Presented by the Cancer Center and the Department of Biochemistry and Molecular Genetics.

Click here for website.

Click here for new
Funding Opportunities.


upcoming events

Discovery of a Novel Hepatitis C Virus Entry Factor and Potential Therapeutic Target to Reduce HCV-Associated HCC
Susan Uprichard, PhD
Tuesday, March 20, 12-1:00PM
900 S. Ashland, Rm. 1152

Presented by the University of Illinois Cancer Center by invitation of Cell Signaling Program

The Tenth Annual Cancer Survivorship Series: Living With, Through & Beyond Cancer
Tuesday, Mar. 20, 12:30-1:30PM

A four-part workshop series via teleconference or live streaming through the internet.
Presented by Cancercare

Role of Protein Kinase D in Actin Reorganization
Peter Storz, PhD
Wednesday, March 21, 12:00-1:00PM
909 S. Wolcott St., Room 1020

Call 312-996-7635 for more information.
Presented by the Department of Pharmacology

RNA regulation of EMT and breast cancer
Chonghui Cheng, MD, PhD
Wednesday, March 21, 12:00pm
909 S. Ashland, Herman Auditorium
Presented by Department of Biochemistry and Molecular Genetics

Designed Nanoparticles for Drug Delivery
Samir Mitragotri, Ph.D.
Wednesday, March 21, 3:30-4:30PM
College of Pharmacy
833 S. Wood, Rm 134-3
Presented by the Department of Biopharmaceutical Sciences



REDCap 101
Tuesday, Mar. 27, 2:00-4:00 PM
909 S. Wolcott, Rm. 5175
Register here.

Breast/Ovarian Health 101
Saturday, March 31, 12:00-2:30PM
RSVP by March 28
6220 South Ingleside Avenue, Chicago

Presented by Bright Pink, Sisters Working It Out, and University of Illinois Cancer Center.

Oncogenomics of B-Cell Lymphoma
Riccardo Dalla-Favera, MD
Monday, Apr. 2   10:00AM
900 S. Ashland, Herman Auditorium (entrance on Marshfield)
Presented by the University of Illinois Cancer Center by invitation of the Cancer Cell Signaling Program.

REDCap 102
Tuesday, Apr. 3, 2:00-4:00 PM
909 S. Wolcott, Rm. 5175
Prerequisite: REDCap 101
Register here.

Frontiers in Cancer Research
Wednesday, April 4 2:00-5:30pm
Elaine Mardis, PhD
Louis M. Staudt, MD, PhD
William Sellers, MD
Jiri Bartek, MD, PhD
900 S. Ashland, Herman Auditorium

Presented by the Cancer Center and the Department of Biochemistry and Molecular Genetics.

2012 Cancer Community @ Illinois Symposium
Thursday-Friday, Apr. 5-6
Micro and Nanotechnology Lab MNTL and Beckman Institute
University of Illinois at Urbana-Champaign
Click here to register.
Presented by the University of Illinois' Cancer Community at Illinois.

Regulation of Anoikis and Epithelial-Mesenchymal-Transition (EMT) in Prostate Cancer Progression
Natasha Kyprianou, PhD
Tuesday, Apr. 10  2:00-4:00PM
909 S. Wolcott, Moss Auditorium
Presented by the University of Illinois Cancer Center by invitation of the Carcinogenesis and Chemoprevention Program.
Presented LIVE via videoconference to these locations:
Peoria: A115
Rockford: Room E213
Urbana: MNTL, 208 N. Wright St., Room 1000

Investigating the Etiology of Aggressive Breast Cancer in African-American Women
Christine P. Ambrosone,PhD
Wednesday, Apr. 25    12:00PM
College of Pharmacy
833 S. Wood, Room 134-1
Presented by the University of Illinois Cancer Center and the Center for Population Health and Health Disparities. The Center for Population Health and Health Disparities is funded by a grant from the  National Cancer Institute (No. 2P50CA106743) and supported by the UIC Institute for Health Research and Policy.

Translational Approaches to Reduce Health Disparities in Lung Disease
April 25-26, 2012
University Club, 76 E. Monroe

Session on Lung Cancer:
Viswanathan Natarajan, PhD, Chair
Thursday, April 26, 8:30-10:00am
Health Disparities in Lung Cancer
Patrick Nana-Sinkam, MD
Genomic Biomarkers in Lung Cancer: Focus on Disparities
Avrum Spira, MD

$50 fee. Registration required at:
Presented by the University of Illinois Hospital & Health Sciences System and the Institute of Personalized Respiratory Medicine (UIC)

The Association of Obesity/Type 2 Diabetes and Cancer Risk: Is Hyperinsulinemia a Culprit?
Derek LeRoith, MD, PhD
Friday, Apr. 27    10:00AM
909 S. Wolcott, Moss Auditorium
Presented by the University of Illinois Cancer Center by invitation of the Carcinogenesis and Chemoprevention Program.


Recent Publications

The Effects of Smoking-Related Television Advertising on Smoking and Intentions to Quit Among Adults in the United States:  1999-2007.
S. Emery, F.J.  Chaloupka, et al.
Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast CancersJ. Frasor, et al.

Unusual CNS presentation of thyroid cancer.
H. H. Engelhard, et al.

The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin.
J.L. Bolton, G.R. Thatcher, et al.
Stool-fermented Plantago ovata husk induces apoptosis in colorectal cancer cells independently of molecular phenotype.
X. Llor, et al.

Specific effects of BCL10 Serine mutations on phosphoryltions in canonical and noncanonical pathways of NF-κB activation following carrageenan.
J.K. Tobacman, et al.

Linear accelerator-based intensity-modulated total marrow irradiation technique for treatment of hematologic malignancies: a dosimetric feasibility study.
J. A. Radosevich, et al.

The Estrogen-Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells
B.S. Katzenellenbogen, et al.

Lycopene and apo-10'-lycopenal do not alter DNA methylation of GSTP1 in LNCaP cells
J.W. Erdman, et al.





new funding opportunities

University of Illinois Cancer Center
2012 Cancer Center Pilot Project
Deadline: LOI Feb. 27; App Apr. 2
To foster high quality interdisciplinary cancer research collaborations between researchers at Chicago, Peoria, Rockford, and Urbana campuses and the four University of Illinois Cancer Center research programs. More...     

Detection, Diagnosis, and Prognosis (R21)

National Cancer Institute (NCI)
Deadline:  App June 16, 2012; Oct. 16, 2012; Feb. 16 2013
Seeking applications from institutions and organizations that are interested in developing and testing innovative methods in cancer detection, diagnosis, and prognosis  More…

Ovarian Cancer Academy Award – Early-Career Investigator
Ovarian Cancer Research Program (OCRP)

Deadline:  App April 17, 2012; July 18 2012
 The award is intended to be a unique, interactive virtual academy providing intensive mentoring, national networking, and a peer group for junior faculty. More…

Investigator-Initiated Research Award

Peer Reviewed Medical Research Program (PRMRP)
Deadline:  App April 10, 2012; July 31, 2012
This award is intended to support studies that will make an important contribution toward understanding mechanisms of initiation, or progression of, and/or improving patient care for a disease or a condition related to at least one of the congressionally directed FY12 PRMRP topic areas.  More…

Biomarkers for Early Detection of Hematopoietic Malignancies (R01)
National Cancer Institute (NCI)
Deadline:  App June 5, 2012; Oct. 5, 2012; Feb. 5, 2013

This FOA encourages research grant applications from institutions and organizations for the development and validation of biomarkers for early detection, prediction of progression, and recurrence of hematopoietic malignancies, especially in high-risk individuals; and for risk assessment of primary and secondary hematopoietic malignancies. More…

Academic-Industrial Partnerships for Translation in in vivo Imaging Systems for Cancer Investigations (R01)
National Cancer Institute (NCI)
Deadline: App June 5, 2012; Oct. 5, 2012; Feb. 5, 2013

This FOA encourages applications from research partnerships formed by academic and industrial investigators to accelerate the translation of either animal or human in vivo imaging, image guided, and/or spectroscopic systems and methods designed to solve targeted cancer problems for cancer research, clinical trials, and/or clinical practice.  More…

Biology of Manual Therapies (R21)
National Institutes of Health (NIH)
Deadline: App Oct. 16, 2012; Feb. 16, 2013; June 16, 2013

This FOA encourages research grant applications (R21) from institutions/organizations that propose to investigate the basic science and mechanisms of action underlying the biomechanical, immunological, endocrinological and/or neurophysiological consequences of manual therapies, such as spinal manipulation, mobilization and massage therapy.  More…





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