December 2, 2011

CANCER CENTER UPDATE


News briefs


Raychaudhuri named University Scholar

The Cancer Center salutes member Pradip Raychaudhuri, PhD, who was recently named a 2011 University Scholar. Raychaudhuri was among only seven UIC faculty members to receive the important prize, which honors excellence in research and teaching-- More...

 

Rao receives College of Medicine award

The Cancer Center congratulates Jasti Rao, PhD, who received the UIC Faculty of the Year Award. More...

 

Schmidt accepts $50,000 pediatrics donation

Mary Lou Schmidt, MD, got behind the wheel of the#45 B+ Racing BMW More...

Spotlight: Flow Cytometry Shared Resource


To facilitate cutting-edge research, the University of Illinois Cancer Center has been pleased to provide its members not only access to, but also a subsidy for, four Lab Shared Resources within the Research Resource Center (RRC). One of these resources is Flow Cytometry Service (FCS), headed by Academic Director Zhijian Qian, PhD.

Flow cytometry is a method used to measure relative size, granularity, and fluorescence of single cells in a population of cells suspended in a liquid medium. It allows simultaneous multi-parametric analysis of the physical and chemical traits of microscopic particles. It is essential in both research and clinical practice. Various uses of flow cytometry consist of measurements of auto fluorescent proteins, antigen or ligand density, apoptosis, enzyme activity, DNA and RNA content, membrane potential, cytokine receptors and its synthesis, drug uptake and efflux, phagocytosis and viability obtained from cells, isolated nuclei, organelles or microorganisms. Changes in cell cycle, intracellular pH, intracellular calcium, intracellular glutathione and oxidative burst can be also detected with these instruments.

According to Academic Director Qian: “The technology has broad applications in medicine. The FCS is significantly helpful to researchers in a wide array of medical fields specifically cell biology, molecular biology and pathology. For the Cancer Center, this service is a vital tool in hematology, tumor immunology, chemotherapy and genetics.”

A fully-operational center that includes a traditional cell sorter: the Beckman-Coulter Elite ESP; a high speed sorter: the Beckman Coulter Legacy MoFlo; and a Bio-Rad Bio-Plex flow cytometer, the FCS also includes four bench-top flow cytometers (used strictly as analyzers), a multiplex analyzer, a cell counter, and a magnetic bead sorter that is often used as a pre-sorter of rare cells before sorting for greater purity on one of the sorting flow cytometers. (see table below for full list of instruments). The FCS also provides consultation and project planning for researchers, and this valuable service is also available to Cancer Center members.

Mfr. Model # Name
Beckman Coulter Cyan ADP CYAN
Becton Dickinson LSR I LSR
Bio-Rad Bio-Plex Bio-Plex
Beckman Coulter EPICS Elite ESP ELITE
Invitrogen Cell Counter Countess Cell Counter
Beckman Coulter MoFlo MoFlo
Miltenyi-Biotec AutoMACS AutoMACS
Becton Dickinson FACSCalibur FACSCalibur

Utilizing this resource is a simple process and we strongly encourage members to take advantage of this benefit of membership. The FCS has an online scheduling system that allows users to place reservations on specific instruments, as well as a sample submission form. The FCS is located on the west campus in the Medical Sciences Buildings (MSB), Rooms E-25 and E-20. Hours are by appointment.

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Leadership Spotlight: Zhijian Qian, PhD, Academic Director of Flow Cytometry

Zhijian Qian, PhD, has been Academic Director of Flow Cytometry since last April. He is a member of the Cancer Cell Signaling Program, and he is interested in the molecular pathways involved in the development of malignant hematological diseases. His research is focused on the biology of myelodysplastic syndrome (MDS) and therapy-related MDS (t-MDS), with emphasis on studying molecular events during the initiation of transformation of a normal stem or progenitor cell into a leukemia-initiating cell (LIC). His goal is to determine the genetic pathways that control the proliferation, survival and self-renewal of normal or leukemic hematopoietic stem cells by genetic and genomic approaches.

Dr. Qian received his doctoral degree in Cell and Molecular Biology from Shanghai Institute of Cell Biology at the Chinese Academy of Sciences. He held a research faculty appointment at the University of Chicago’s Hematology/Oncology section before joining UIC in 2010.

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Raychaudhuri (continued)
research that focuses on the role in the termination of DNA damage response and sensitizing tumor cells to chemotherapy as well as FoxM1’s role in tumor metastasis; and teaching that includes his supervision of four students who assist in his lab investigations.

Cancer Center Director Howard Ozer, MD, PhD, states: “The prize is immensely well-deserved.  We are proud and fortunate that the Cancer Center has a researcher like Pradip in our midst. We are particularly grateful for his active focus on maintaining collaborations with other Cancer Center members.”

“We are delighted that Pradip's scientific contributions in the field of cell cycle control and cancer biology have been recognized by this prestigious University award.  His efforts as a mentor and active researcher are widely appreciated in the UI Cancer Center community,” remarks Jack Kaplan, PhD, FRS, Professor and Head of Biochemistry and Molecular Genetics and the Cancer Center’s Associate Director for Basic Sciences.

Angela Tyner, Cancer Cell Signaling Program Leader, adds: "Pradip is a wonderful colleague and well deserving of this recognition. His accomplishments in enhancing our understanding of molecular mechanisms underlying cancer, particularly his work on Damaged-DNA Binding Protein-2 (DDB2) and the transcription factor FoxM1, have earned him international recognition."

Pradip Raychaudhuri is Professor of Biochemistry and Molecular Genetics in the College of Medicine and a member of the Cancer Cell Signaling Program.  Hebegan his career at UIC in 1990 and was immediately involved with cancer research. He has participated actively in the Cancer Center, serving from 2008-2010 as Program Leader for the Cancer Cell Signaling Program (then named Tumor Cell Biology).

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Rao (continued)
He is the Senior Associate Dean for Research and Head of Cancer Biology and Pharmacology at the Peoria campus and a member of the Cancer Cell Signaling Program.

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Schmidt (continued)
M3 car that was co-driven by Al Carter and Hugh Plumb at the Mid-Ohio Sports Car Course in Lexington, Ohio. Carter, Plumb, and Joe McDonough, co-founder of B+ Foundation, all work to raise awareness for pediatric cancer. The donation benefits the Children’s Oncology Group (COG) Clinical Trials Program at the Children’s Hospital University of Illinois, and other medical centers. Schmidt is Associate Professor of Pediatrics and a member of the Cancer Targeting, Therapeutics and Imaging Program.

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In this issue

  spotlight: fLOW cYTOMETRY sHARED rESOURCE
 

leadership spotlight: zHIJIAN qIAN, pHd, fLOW CYTOMETRY aCADEMIC dIRECTOR

 

upcoming events

 

Recent Publications

  new funding opportunities

Flow Cytometry is one of four Lab Shared Resources for which the Cancer Center provides subsidies to its members. The current subsidy rate of 30% is effective until March 31, 2012. This is an important benefit of your membership that we encourage you to utilize.
Click here for more information.


Click here for new
Funding Opportunities.


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upcoming events


Explosive Nature of Simple DNA Repeats
Segei Mirkin, PhD
Thursday, Dec. 8, 11:00AM-12:00PM
MBRB
900 S. Ashland, Herman Auditorium

Prevention of Estrogen Carcinogenesis by Selective Estrogen Receptor Modulators (SERMs) and Botanical Dietary Supplements
Judy L. Bolton, PhD
Thursday, Dec. 8, 12:00-1:00PM
COMRB
909 S. Wolcott, Rm. 5175

Presented by the Carcinogenesis and Chemoprevention Program.

REDCap 101
Tuesday, Dec. 13, 2:00-4:00PM

COMRB
909 S. Wolcott, Rm. 5175
Register at http://121311redcap101.eventbrite.com/

Membrane-Anchored Serine Proteases in Epithelial Development and Carcinogenesis
Thomas Bugge
Tuesday, Dec. 13, 12:30-1:30PM
College of Dentistry
801 S. Paulina, Rm. 501

Presented by the Center for Molecular Biology of Oral Disease

REDCap 102
Tuesday, Dec. 20, 2:00-4:00PM

COMRB
909 S. Wolcott, Rm. 5175
Register at http://122011redcap102.eventbrite.com/.

Overview of Progress and Plans for the University of Illinois Cancer Center: The External Advisory Board Report
Howard Ozer, MD, PhD
Jan. 5 10:30-11:30AM
COMRB
909 S. Wolcott, Rm. 5175

Presented by the Population Health, Behavior and Outcomes Program

Title TBA
Jonathan Licht, MD
Thursday, Jan. 17
MBRB
900 S. Ashland. Herman Aud.
Presented by Cancer Cell Signaling Program and Center for Molecular Biology of Oral Disease

Outcomes of the Childhood Cancer Survivors Program to Empower Action in Care (SPEAC)
Lisa Sharp, PhD
Wednesday, Jan. 18, 12:00-1:00PM
WROB
1747 W. Roosevelt Rd., Rm. 561

IHRP Brown Bag Lecture

Save the Date!
Cancer Center Town Hall
Howard Ozer, MD, PhD
Thursday, Feb. 23, 3:00PM
COMRB
909 S. Wolcott, Moss Aud.

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Recent Publications

Associations Between Functional Polymorphisms in Antioxidant Defense Genes and Urinary Oxidative Stress Biomarkers in Healthy, Premenopausal Women
P. Gann, R. van Breeman, M. Wright, et al

Inverse Association Between Glutathione Peroxidase Activity and Both Selenium-Binding Protein 1 Levels and Gleason Score in Human Prostate Tissue
A. Diamond, M. Wright, W. Yang, et al

Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression: Role of Chelatable Iron
D.D. Thomas, et al

Phospholipid-based Nanomicelles in Cancer Nanomedicine. Chapter 16 in Nanomedicine in Health and Disease by CRS Press.
H. Onyuksel, et al

 

new funding opportunities

Basic Science Grants
American Cancer Society, Illinois Div.
Deadline: LOI Dec. 2, 2011-Jan 27, 2012

Supports promising, junior level scientists and physicians in the development of their research careersrovides grants to investigators who do not have national-level funding. For more information, click here and scroll down to ACS-Illinois grant listing.

Center for Clinical and Translational Science (CCTS) Scholars Award
Center for Clinical and Translational Science
Deadline: App. Jan. 17, 2012

Supports the research efforts and career development of clinician scientists dedicated to patient-oriented research in clinical disciplines and professions. More…

CCTS Just-in-Time Funding 
Center for Clinical and Translational Sciences
Deadline: App Rolling
Supports the success of externally-funded research grant applications addressing topics of relevance to clinical-translational science. More…

Fight Colorectal Cancer-AACR Career Development Award, in memory of Lisa Dubow
American Association for Cancer Research
Deadline: App Jan. 17, 2012, Jan. 19, 2012

Restricted to translational or clinical cancer research that has an ultimate goal of developing or improving therapeutic interventions for patients with metastatic colorectal cancer. More…

Career Development Program in Diabetes Research for Behavioral Scientists
National Institute of Diabetes and Digestive and Kidney Diseases
Deadline: LOI Feb. 2, 2012; App Mar. 2, 2012

Fosters the development of a diverse and highly trained workforce of behavioral scientists to assume leadership roles related to the nation’s research efforts in the area of type 1 diabetes. More…

Cancer Research Grant Program
Mary Kay Foundation
Deadline: App Feb. 3, 2012

Provides innovative grants for translational research in ovarian, uterine, breast, or cervical cancer. More…

Pfizer Fellowship in Health Disparities
Pfizer
Deadline: App Feb. 11, 2012

Focuses on smoking-cessation programs, women's health/gender medicine, and preventive healthcare to address disparities among populations. More…

Neuroimmunology of Brain Infections and Cancers
Dana Foundation
Deadline: App Feb. 22, 2012

Invites studies of immune-based therapies for primary brain tumors, and for metastases to the brain of other cancers. More…

Student Bursaries - Childhood Cancer 2012 Conference - Early Exposures and Childhood Cancer
Children With Cancer UK
Deadline: App Jan. 12, 2012

Childhood Cancer 2012 is Children With Cancer UK's international scientific conference on early exposures and childhood cancer. More…

Validation of Molecular Diagnostics to Predict Patient Outcomes Using Specimens from Multi-Site Cancer Trials
National Cancer Institute
Deadline: App Feb. 16, 2012, Jun. 16, 2012, Oct. 16, 2012

Encourages the submission of Exploratory/Developmental Research Project Grant (R21) applications to validate the clinical utility of new molecular diagnostics for determining prognosis or predicting response to therapy or toxicity for cancer. More…

Research Awards in Brain Cancer Research
James S. McDonnell Foundation
Deadline: App Mar. 14, 2012

Supports research projects with a high probability of generating new knowledge and insights. More…

 

 

 

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